Delayed Surgical Resection After Long-course Neoadjuvant Chemoradiotherapy in Rectal Cancer: Single Center Experience
Introduction:The aim of this study was to evaluate whether delayed rectal cancer surgery after long-course neoadjuvant concomitant chemoradiotherapy was effective on pathological complete response (pCR), disease-free survival (DFS), and overall survival (OS).Methods:A total of 112 patients with rect...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2019-09-01
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| Series: | İstanbul Medical Journal |
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http://imj.galenos.com.tr/archives/archive-detail/article-preview/delayed-surgical-resection-after-long-course-neoad/30576
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| author | Özlem Mermut Berrin İnanç Esra Arslan Hasan Bektaş Nevra Dursun Aytul Hande Yardımcı |
| author_facet | Özlem Mermut Berrin İnanç Esra Arslan Hasan Bektaş Nevra Dursun Aytul Hande Yardımcı |
| author_sort | Özlem Mermut |
| collection | DOAJ |
| description | Introduction:The aim of this study was to evaluate whether delayed rectal cancer surgery after long-course neoadjuvant concomitant chemoradiotherapy was effective on pathological complete response (pCR), disease-free survival (DFS), and overall survival (OS).Methods:A total of 112 patients with rectal carcinoma diagnosed at the Radiation Oncology Clinic between 2011 and 2017 were retrospectively analyzed. We compared the outcomes of patients who were operated on greater than >9 weeks (delayed surgery) and less than <8 weeks (early surgery) after completion of neoadjuvant chemoradiotherapy.Results:When we compared the delayed and early surgery groups, pCR rate was higher in the Delayed surgery group (18.2% vs. 5.2%, p=0.032). Tumor regression was found to be close to statistical significance in the delayed surgery group (p=0.050). The decrease in postoperative T stage was found to be statistically significant in the delayed surgery group (p=0.007). When the study was completed, the patient group who underwent delayed surgery had a longer life and this was statistically significant (p=0.044). The OS rate (p=0.004) and DFS rate (p=0.003) was statistically significant in the delayed surgery group.Conclusion:Delaying surgery after neoadjuvant chemoradiotherapy increases the pCR rate, DFS and OS. |
| first_indexed | 2024-04-10T10:17:31Z |
| format | Article |
| id | doaj.art-18052e2a0d9249e1bfa154a311dbfe92 |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T10:17:31Z |
| publishDate | 2019-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-18052e2a0d9249e1bfa154a311dbfe922023-02-15T16:21:46ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2019-09-0120542443010.4274/imj.galenos.2019.5013313049054Delayed Surgical Resection After Long-course Neoadjuvant Chemoradiotherapy in Rectal Cancer: Single Center ExperienceÖzlem Mermut0Berrin İnanç1Esra Arslan2Hasan Bektaş3Nevra Dursun4Aytul Hande Yardımcı5 University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Radiation Oncology, İstanbul, Turkey University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Radiation Oncology, İstanbul, Turkey University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey University of Health Sciences, İstanbul Training and Research Hospital, Clinic of General Surgery, İstanbul, Turkey University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Pathology, İstanbul, Turkey University of Health Sciences, İstanbul Training and Research Hospital, Clinic of Radiology, İstanbul, Turkey Introduction:The aim of this study was to evaluate whether delayed rectal cancer surgery after long-course neoadjuvant concomitant chemoradiotherapy was effective on pathological complete response (pCR), disease-free survival (DFS), and overall survival (OS).Methods:A total of 112 patients with rectal carcinoma diagnosed at the Radiation Oncology Clinic between 2011 and 2017 were retrospectively analyzed. We compared the outcomes of patients who were operated on greater than >9 weeks (delayed surgery) and less than <8 weeks (early surgery) after completion of neoadjuvant chemoradiotherapy.Results:When we compared the delayed and early surgery groups, pCR rate was higher in the Delayed surgery group (18.2% vs. 5.2%, p=0.032). Tumor regression was found to be close to statistical significance in the delayed surgery group (p=0.050). The decrease in postoperative T stage was found to be statistically significant in the delayed surgery group (p=0.007). When the study was completed, the patient group who underwent delayed surgery had a longer life and this was statistically significant (p=0.044). The OS rate (p=0.004) and DFS rate (p=0.003) was statistically significant in the delayed surgery group.Conclusion:Delaying surgery after neoadjuvant chemoradiotherapy increases the pCR rate, DFS and OS. http://imj.galenos.com.tr/archives/archive-detail/article-preview/delayed-surgical-resection-after-long-course-neoad/30576 rectal cancerdelayed surgeryneoadjuvant longcourse radiotherapychemotherapy |
| spellingShingle | Özlem Mermut Berrin İnanç Esra Arslan Hasan Bektaş Nevra Dursun Aytul Hande Yardımcı Delayed Surgical Resection After Long-course Neoadjuvant Chemoradiotherapy in Rectal Cancer: Single Center Experience İstanbul Medical Journal rectal cancer delayed surgery neoadjuvant longcourse radiotherapy chemotherapy |
| title | Delayed Surgical Resection After Long-course Neoadjuvant Chemoradiotherapy in Rectal Cancer: Single Center Experience |
| title_full | Delayed Surgical Resection After Long-course Neoadjuvant Chemoradiotherapy in Rectal Cancer: Single Center Experience |
| title_fullStr | Delayed Surgical Resection After Long-course Neoadjuvant Chemoradiotherapy in Rectal Cancer: Single Center Experience |
| title_full_unstemmed | Delayed Surgical Resection After Long-course Neoadjuvant Chemoradiotherapy in Rectal Cancer: Single Center Experience |
| title_short | Delayed Surgical Resection After Long-course Neoadjuvant Chemoradiotherapy in Rectal Cancer: Single Center Experience |
| title_sort | delayed surgical resection after long course neoadjuvant chemoradiotherapy in rectal cancer single center experience |
| topic | rectal cancer delayed surgery neoadjuvant longcourse radiotherapy chemotherapy |
| url |
http://imj.galenos.com.tr/archives/archive-detail/article-preview/delayed-surgical-resection-after-long-course-neoad/30576
|
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