High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model

High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model

Abstract The alpha-fetoprotein receptor (AFPR) is a novel target for cancer therapeutics. It is expressed on most cancers and myeloid derived suppressor cells (MDSCs) but generally absent on normal tissues. Studies were performed to investigate the use of recombinant human AFP (ACT-101) conjugated w...

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Bibliographic Details
Main Authors: Patricia Griffin, Wendy A. Hill, Fabio Rossi, Rebecca Boohaker, Karr Stinson, Igor Sherman
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cancer Cell International
Subjects:
Alpha-fetoprotein-maytansinoid conjugate
Colorectal cancer
AFP receptor
Tumor targeting
Online Access:https://doi.org/10.1186/s12935-023-02910-0

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