Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction
Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Because Alzheimer's disease has no known treatment, sufferers and their caregivers must concentrate on symptom management. Astrocytes and microglia are now known to play distinct physiological roles in synaptic function, t...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266724212200094X |
| _version_ | 1797804509706059776 |
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| author | Michael Kunle Ajenikoko Abayomi Oyeyemi Ajagbe Oluwanisola Akanji Onigbinde Akeem Ayodeji Okesina Ahmad Adekilekun Tijani |
| author_facet | Michael Kunle Ajenikoko Abayomi Oyeyemi Ajagbe Oluwanisola Akanji Onigbinde Akeem Ayodeji Okesina Ahmad Adekilekun Tijani |
| author_sort | Michael Kunle Ajenikoko |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Because Alzheimer's disease has no known treatment, sufferers and their caregivers must concentrate on symptom management. Astrocytes and microglia are now known to play distinct physiological roles in synaptic function, the blood-brain barrier, and neurovascular coupling. Consequently, the search for drugs that can slow the degenerative process in dementia sufferers continues because existing drugs are designed to alleviate the symptoms of Alzheimer’s disease. Drugs that address pathological changes without interfering with the normal function of glia, such as eliminating amyloid-beta deposits, are prospective treatments for neuroinflammatory illnesses. Because neuron-astrocytes-microglia interactions are so complex, developing effective, preventive, and therapeutic medications for AD will necessitate novel methodologies and strategic targets. This review focused on existing medications used in treating AD amongst which include Donepezil, Choline Alphoscerate, Galantamine, Dextromethorphan, palmitoylethanolamide, citalopram, resveratrol, and solanezumab. This review summarizes the effects of these drugs on neurons, astrocytes, and microglia interactions based on their pharmacokinetic properties, mechanism of action, dosing, and clinical presentations. |
| first_indexed | 2024-03-13T05:38:15Z |
| format | Article |
| id | doaj.art-180752fe132446e0979eac99cbf7d1d3 |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-13T05:38:15Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-180752fe132446e0979eac99cbf7d1d32023-06-14T04:34:35ZengElsevierIBRO Neuroscience Reports2667-24212023-06-01146476Review of Alzheimer’s disease drugs and their relationship with neuron-glia interactionMichael Kunle Ajenikoko0Abayomi Oyeyemi Ajagbe1Oluwanisola Akanji Onigbinde2Akeem Ayodeji Okesina3Ahmad Adekilekun Tijani4Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Ishaka, Uganda; Correspondence to: Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Uganda.Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nile University of Nigeria, P.M.B. 900001 Abuja, NigeriaDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nile University of Nigeria, P.M.B. 900001 Abuja, NigeriaDepartment of Clinical Medicine and Community Health, School of Health Sciences, College of Medicine and Health Sciences, University of Rwanda, RwandaDepartment of Anatomy, Faculty of Basic Medical Sciences, Modibbo Adama University, Yola, NigeriaAlzheimer’s disease (AD) is the most common cause of dementia worldwide. Because Alzheimer's disease has no known treatment, sufferers and their caregivers must concentrate on symptom management. Astrocytes and microglia are now known to play distinct physiological roles in synaptic function, the blood-brain barrier, and neurovascular coupling. Consequently, the search for drugs that can slow the degenerative process in dementia sufferers continues because existing drugs are designed to alleviate the symptoms of Alzheimer’s disease. Drugs that address pathological changes without interfering with the normal function of glia, such as eliminating amyloid-beta deposits, are prospective treatments for neuroinflammatory illnesses. Because neuron-astrocytes-microglia interactions are so complex, developing effective, preventive, and therapeutic medications for AD will necessitate novel methodologies and strategic targets. This review focused on existing medications used in treating AD amongst which include Donepezil, Choline Alphoscerate, Galantamine, Dextromethorphan, palmitoylethanolamide, citalopram, resveratrol, and solanezumab. This review summarizes the effects of these drugs on neurons, astrocytes, and microglia interactions based on their pharmacokinetic properties, mechanism of action, dosing, and clinical presentations.http://www.sciencedirect.com/science/article/pii/S266724212200094XAlzheimerInflammationGalantamineDextromethorphanAlphoscerateNeuron-glia |
| spellingShingle | Michael Kunle Ajenikoko Abayomi Oyeyemi Ajagbe Oluwanisola Akanji Onigbinde Akeem Ayodeji Okesina Ahmad Adekilekun Tijani Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction IBRO Neuroscience Reports Alzheimer Inflammation Galantamine Dextromethorphan Alphoscerate Neuron-glia |
| title | Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction |
| title_full | Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction |
| title_fullStr | Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction |
| title_full_unstemmed | Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction |
| title_short | Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction |
| title_sort | review of alzheimer s disease drugs and their relationship with neuron glia interaction |
| topic | Alzheimer Inflammation Galantamine Dextromethorphan Alphoscerate Neuron-glia |
| url | http://www.sciencedirect.com/science/article/pii/S266724212200094X |
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