White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups
Subcortical white matter hyperintensities (WMHs) in the aging population frequently represent vascular injury that may lead to cognitive impairment. WMH progression is well described, but the factors underlying WMH regression remain poorly understood. A sample of 351 participants from the Alzheimer&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/9/7/170 |
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| author | Omar M. Al-Janabi Christopher E. Bauer Larry B. Goldstein Richard R. Murphy Ahmed A. Bahrani Charles D. Smith Donna M. Wilcock Brian T. Gold Gregory A. Jicha |
| author_facet | Omar M. Al-Janabi Christopher E. Bauer Larry B. Goldstein Richard R. Murphy Ahmed A. Bahrani Charles D. Smith Donna M. Wilcock Brian T. Gold Gregory A. Jicha |
| author_sort | Omar M. Al-Janabi |
| collection | DOAJ |
| description | Subcortical white matter hyperintensities (WMHs) in the aging population frequently represent vascular injury that may lead to cognitive impairment. WMH progression is well described, but the factors underlying WMH regression remain poorly understood. A sample of 351 participants from the Alzheimer’s Disease Neuroimaging Initiative 2 (ADNI2) was explored who had WMH volumetric quantification, structural brain measures, and cognitive measures (memory and executive function) at baseline and after approximately 2 years. Selected participants were categorized into three groups based on WMH change over time, including those that demonstrated regression (<i>n</i> = 96; 25.5%), stability (<i>n</i> = 72; 19.1%), and progression (<i>n</i> = 209; 55.4%). There were no significant differences in age, education, sex, or cognitive status between groups. Analysis of variance demonstrated significant differences in atrophy between the progression and both regression (<i>p</i> = 0.004) and stable groups (<i>p</i> = 0.012). Memory assessments improved over time in the regression and stable groups but declined in the progression group (<i>p</i> = 0.003; <i>p</i> = 0.018). WMH regression is associated with decreased brain atrophy and improvement in memory performance over two years compared to those with WMH progression, in whom memory and brain atrophy worsened. These data suggest that WMHs are dynamic and associated with changes in atrophy and cognition. |
| first_indexed | 2024-12-19T06:25:36Z |
| format | Article |
| id | doaj.art-18081d1ae69a4c24a313da0c68e3e9e9 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-19T06:25:36Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-18081d1ae69a4c24a313da0c68e3e9e92022-12-21T20:32:34ZengMDPI AGBrain Sciences2076-34252019-07-019717010.3390/brainsci9070170brainsci9070170White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable GroupsOmar M. Al-Janabi0Christopher E. Bauer1Larry B. Goldstein2Richard R. Murphy3Ahmed A. Bahrani4Charles D. Smith5Donna M. Wilcock6Brian T. Gold7Gregory A. Jicha8Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USADepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY 40508, USADepartment of Neurology, College of Medicine, University of Kentucky, Lexington, KY 40508, USADepartment of Neurology, College of Medicine, University of Kentucky, Lexington, KY 40508, USASanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USASanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USASanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USASanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USASanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USASubcortical white matter hyperintensities (WMHs) in the aging population frequently represent vascular injury that may lead to cognitive impairment. WMH progression is well described, but the factors underlying WMH regression remain poorly understood. A sample of 351 participants from the Alzheimer’s Disease Neuroimaging Initiative 2 (ADNI2) was explored who had WMH volumetric quantification, structural brain measures, and cognitive measures (memory and executive function) at baseline and after approximately 2 years. Selected participants were categorized into three groups based on WMH change over time, including those that demonstrated regression (<i>n</i> = 96; 25.5%), stability (<i>n</i> = 72; 19.1%), and progression (<i>n</i> = 209; 55.4%). There were no significant differences in age, education, sex, or cognitive status between groups. Analysis of variance demonstrated significant differences in atrophy between the progression and both regression (<i>p</i> = 0.004) and stable groups (<i>p</i> = 0.012). Memory assessments improved over time in the regression and stable groups but declined in the progression group (<i>p</i> = 0.003; <i>p</i> = 0.018). WMH regression is associated with decreased brain atrophy and improvement in memory performance over two years compared to those with WMH progression, in whom memory and brain atrophy worsened. These data suggest that WMHs are dynamic and associated with changes in atrophy and cognition.https://www.mdpi.com/2076-3425/9/7/170white matter hyperintensitiesWMH regressionWMH progressionStable WMHADNI, brain atrophy, cognition |
| spellingShingle | Omar M. Al-Janabi Christopher E. Bauer Larry B. Goldstein Richard R. Murphy Ahmed A. Bahrani Charles D. Smith Donna M. Wilcock Brian T. Gold Gregory A. Jicha White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups Brain Sciences white matter hyperintensities WMH regression WMH progression Stable WMH ADNI, brain atrophy, cognition |
| title | White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups |
| title_full | White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups |
| title_fullStr | White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups |
| title_full_unstemmed | White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups |
| title_short | White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups |
| title_sort | white matter hyperintensity regression comparison of brain atrophy and cognitive profiles with progression and stable groups |
| topic | white matter hyperintensities WMH regression WMH progression Stable WMH ADNI, brain atrophy, cognition |
| url | https://www.mdpi.com/2076-3425/9/7/170 |
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