Diagnostic value of platelet indices in infected nonunion: a retrospective study
Abstract Background The diagnostic value of platelet indices has been evaluated in various infectious diseases but not in infected nonunion. The purpose of this study was to assess the usefulness of platelet indices for diagnosis of infected nonunion after open reduction and internal fixation. Metho...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-022-03096-3 |
| _version_ | 1818015285340274688 |
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| author | Zhen Wang Hai-Jun Mao Xu-Sheng Qiu Yi-Xin Chen Guang-Yue Xu |
| author_facet | Zhen Wang Hai-Jun Mao Xu-Sheng Qiu Yi-Xin Chen Guang-Yue Xu |
| author_sort | Zhen Wang |
| collection | DOAJ |
| description | Abstract Background The diagnostic value of platelet indices has been evaluated in various infectious diseases but not in infected nonunion. The purpose of this study was to assess the usefulness of platelet indices for diagnosis of infected nonunion after open reduction and internal fixation. Methods This retrospective study was performed in patients who underwent primary fracture nonunion revision surgeries from January 2016 to December 2021. A total of 297 patients were included in the study: 96 with infected nonunion (group A) and 201 with aseptic nonunion (group B). Receiver operator characteristic (ROC) curve analysis was performed to evaluate diagnostic value of each index. Area under the curve (AUC), sensitivity, specificity, and positive and negative predictive values were calculated and compared. Results Demographic characteristics were comparable between the two groups. White blood cell (WBC) count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), plasma fibrinogen, plasma D-dimer, platelet count (PC), plateletcrit, and ratio of platelet count to mean platelet volume (PC/MPV) were significantly higher, and MPV and platelet distribution width (PDW) significantly lower, in group A than in group B (P < 0.05). ROC analysis showed PC/MPV and plasma fibrinogen to have better diagnostic value than the other coagulation indicators (AUC of 0.801 and 0.807, respectively). The combination of ESR, plasma fibrinogen, and PC/MPV had good sensitivity and specificity for diagnosis of infected nonunion. PC/MPV had better diagnostic value than ESR and plasma fibrinogen in the subgroup of patients with coagulation-related comorbidities. Conclusions Plasma fibrinogen and PC/MPV ratio might be useful parameters for early diagnosis of infected nonunion. |
| first_indexed | 2024-04-14T06:54:58Z |
| format | Article |
| id | doaj.art-18094b7199a844bf9f15b93a246600fb |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-14T06:54:58Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-18094b7199a844bf9f15b93a246600fb2022-12-22T02:06:55ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2022-04-011711810.1186/s13018-022-03096-3Diagnostic value of platelet indices in infected nonunion: a retrospective studyZhen Wang0Hai-Jun Mao1Xu-Sheng Qiu2Yi-Xin Chen3Guang-Yue Xu4Department of Orthopedics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Orthopedics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Orthopedics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Orthopedics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Orthopedics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolAbstract Background The diagnostic value of platelet indices has been evaluated in various infectious diseases but not in infected nonunion. The purpose of this study was to assess the usefulness of platelet indices for diagnosis of infected nonunion after open reduction and internal fixation. Methods This retrospective study was performed in patients who underwent primary fracture nonunion revision surgeries from January 2016 to December 2021. A total of 297 patients were included in the study: 96 with infected nonunion (group A) and 201 with aseptic nonunion (group B). Receiver operator characteristic (ROC) curve analysis was performed to evaluate diagnostic value of each index. Area under the curve (AUC), sensitivity, specificity, and positive and negative predictive values were calculated and compared. Results Demographic characteristics were comparable between the two groups. White blood cell (WBC) count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), plasma fibrinogen, plasma D-dimer, platelet count (PC), plateletcrit, and ratio of platelet count to mean platelet volume (PC/MPV) were significantly higher, and MPV and platelet distribution width (PDW) significantly lower, in group A than in group B (P < 0.05). ROC analysis showed PC/MPV and plasma fibrinogen to have better diagnostic value than the other coagulation indicators (AUC of 0.801 and 0.807, respectively). The combination of ESR, plasma fibrinogen, and PC/MPV had good sensitivity and specificity for diagnosis of infected nonunion. PC/MPV had better diagnostic value than ESR and plasma fibrinogen in the subgroup of patients with coagulation-related comorbidities. Conclusions Plasma fibrinogen and PC/MPV ratio might be useful parameters for early diagnosis of infected nonunion.https://doi.org/10.1186/s13018-022-03096-3Infected nonunionDiagnosisPlatelet indices |
| spellingShingle | Zhen Wang Hai-Jun Mao Xu-Sheng Qiu Yi-Xin Chen Guang-Yue Xu Diagnostic value of platelet indices in infected nonunion: a retrospective study Journal of Orthopaedic Surgery and Research Infected nonunion Diagnosis Platelet indices |
| title | Diagnostic value of platelet indices in infected nonunion: a retrospective study |
| title_full | Diagnostic value of platelet indices in infected nonunion: a retrospective study |
| title_fullStr | Diagnostic value of platelet indices in infected nonunion: a retrospective study |
| title_full_unstemmed | Diagnostic value of platelet indices in infected nonunion: a retrospective study |
| title_short | Diagnostic value of platelet indices in infected nonunion: a retrospective study |
| title_sort | diagnostic value of platelet indices in infected nonunion a retrospective study |
| topic | Infected nonunion Diagnosis Platelet indices |
| url | https://doi.org/10.1186/s13018-022-03096-3 |
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