Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score
Abstract Background This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery dise...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-11-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40001-017-0290-9 |
| _version_ | 1819054940291596288 |
|---|---|
| author | Jonas Rusnak Michael Behnes Thomas Henzler Nadine Reckord Nils Vogler Mathias Meyer Ursula Hoffmann Michele Natale Julia Hoffmann Sonja Hamed Kathrin Weidner Siegfried Lang Agnibh Mukherji Holger Haubenreisser Stefan O. Schoenberg Martin Borggrefe Thomas Bertsch Ibrahim Akin |
| author_facet | Jonas Rusnak Michael Behnes Thomas Henzler Nadine Reckord Nils Vogler Mathias Meyer Ursula Hoffmann Michele Natale Julia Hoffmann Sonja Hamed Kathrin Weidner Siegfried Lang Agnibh Mukherji Holger Haubenreisser Stefan O. Schoenberg Martin Borggrefe Thomas Bertsch Ibrahim Akin |
| author_sort | Jonas Rusnak |
| collection | DOAJ |
| description | Abstract Background This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD). Methods Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD. Within 24 h of CCT examination, peripheral blood samples were taken to measure cardiac biomarkers hs-cTnI and hs-cTnT. Results A total of 76 patients were enrolled including 38% without detectable CAC, 36% with an Agatston score from 1 to 100, 17% from 101 to 400, and 9% with values ≥ 400. hs-cTnI was increasing alongside Agatston score and was able to differentiate between different groups of Agatston scores. Both hs-cTn discriminated values greater than 100 (hs-cTnI, AUC = 0.663; p = 0.032; hs-cTnT, AUC = 0.650; p = 0.048). In univariate and multivariate logistic regression models, hs-cTnT and hs-cTnI were significantly associated with increased Agatston scores. Patients with hs-cTnT ≥ 0.02 µg/l and hs-cTnI ≥ 5.5 ng/l were more likely to reveal values ≥ 400 (hs-cTnT; OR = 13.4; 95% CI 1.545–116.233; p = 0.019; hs-cTnI; OR = 8.8; 95% CI 1.183–65.475; p = 0.034). Conclusion The present study shows that the Agatston score was significantly correlated with hs cardiac troponins, both in univariable and multivariable linear regression models. Hs-cTnI is able to discriminate between different Agatston values. The present results might reveal potential cut-off values for hs cardiac troponins regarding different Agatston values. Trial registration Cardiovascular Imaging and Biomarker Analyses (CIBER), NCT03074253 https://clinicaltrials.gov/ct2/show/record/NCT03074253 |
| first_indexed | 2024-12-21T12:59:36Z |
| format | Article |
| id | doaj.art-1809ef92c52c49cbbe0447558b6797fa |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-21T12:59:36Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-1809ef92c52c49cbbe0447558b6797fa2022-12-21T19:03:12ZengBMCEuropean Journal of Medical Research2047-783X2017-11-012211910.1186/s40001-017-0290-9Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston scoreJonas Rusnak0Michael Behnes1Thomas Henzler2Nadine Reckord3Nils Vogler4Mathias Meyer5Ursula Hoffmann6Michele Natale7Julia Hoffmann8Sonja Hamed9Kathrin Weidner10Siegfried Lang11Agnibh Mukherji12Holger Haubenreisser13Stefan O. Schoenberg14Martin Borggrefe15Thomas Bertsch16Ibrahim Akin17First Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergDepartment of Internal Medicine III, University Hospital Heidelberg, Faculty of Medicine Heidelberg, University of HeidelbergFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergInstitute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, General Hospital Nuremberg, Paracelsus Medical UniversityFirst Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergAbstract Background This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD). Methods Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD. Within 24 h of CCT examination, peripheral blood samples were taken to measure cardiac biomarkers hs-cTnI and hs-cTnT. Results A total of 76 patients were enrolled including 38% without detectable CAC, 36% with an Agatston score from 1 to 100, 17% from 101 to 400, and 9% with values ≥ 400. hs-cTnI was increasing alongside Agatston score and was able to differentiate between different groups of Agatston scores. Both hs-cTn discriminated values greater than 100 (hs-cTnI, AUC = 0.663; p = 0.032; hs-cTnT, AUC = 0.650; p = 0.048). In univariate and multivariate logistic regression models, hs-cTnT and hs-cTnI were significantly associated with increased Agatston scores. Patients with hs-cTnT ≥ 0.02 µg/l and hs-cTnI ≥ 5.5 ng/l were more likely to reveal values ≥ 400 (hs-cTnT; OR = 13.4; 95% CI 1.545–116.233; p = 0.019; hs-cTnI; OR = 8.8; 95% CI 1.183–65.475; p = 0.034). Conclusion The present study shows that the Agatston score was significantly correlated with hs cardiac troponins, both in univariable and multivariable linear regression models. Hs-cTnI is able to discriminate between different Agatston values. The present results might reveal potential cut-off values for hs cardiac troponins regarding different Agatston values. Trial registration Cardiovascular Imaging and Biomarker Analyses (CIBER), NCT03074253 https://clinicaltrials.gov/ct2/show/record/NCT03074253http://link.springer.com/article/10.1186/s40001-017-0290-9Agatston scoreTroponinHigh-sensitivity troponinCoronary artery diseaseBiomarker |
| spellingShingle | Jonas Rusnak Michael Behnes Thomas Henzler Nadine Reckord Nils Vogler Mathias Meyer Ursula Hoffmann Michele Natale Julia Hoffmann Sonja Hamed Kathrin Weidner Siegfried Lang Agnibh Mukherji Holger Haubenreisser Stefan O. Schoenberg Martin Borggrefe Thomas Bertsch Ibrahim Akin Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score European Journal of Medical Research Agatston score Troponin High-sensitivity troponin Coronary artery disease Biomarker |
| title | Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score |
| title_full | Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score |
| title_fullStr | Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score |
| title_full_unstemmed | Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score |
| title_short | Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score |
| title_sort | comparative analysis of high sensitivity cardiac troponin i and t for their association with coronary computed tomography assessed calcium scoring represented by the agatston score |
| topic | Agatston score Troponin High-sensitivity troponin Coronary artery disease Biomarker |
| url | http://link.springer.com/article/10.1186/s40001-017-0290-9 |
| work_keys_str_mv | AT jonasrusnak comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT michaelbehnes comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT thomashenzler comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT nadinereckord comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT nilsvogler comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT mathiasmeyer comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT ursulahoffmann comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT michelenatale comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT juliahoffmann comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT sonjahamed comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT kathrinweidner comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT siegfriedlang comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT agnibhmukherji comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT holgerhaubenreisser comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT stefanoschoenberg comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT martinborggrefe comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT thomasbertsch comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore AT ibrahimakin comparativeanalysisofhighsensitivitycardiactroponiniandtfortheirassociationwithcoronarycomputedtomographyassessedcalciumscoringrepresentedbytheagatstonscore |