Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD

Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD

Abstract Background Smoking represents a significant risk factor for many chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). Methods To identify dysregulation of specific proteins and pathways in bronchoalveolar lavage (BAL) cells associated with smoking, isobaric...

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Bibliographic Details
Main Authors: Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K. Garberg, Reza Karimi, Johan Grunewald, Frode S. Berven, C. Magnus Sköld, Åsa M. Wheelock
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Respiratory Research
Subjects:
Smoking
Inflammation
Proteomics
COPD
Bronchoalveolar lavage
Online Access:http://link.springer.com/article/10.1186/s12931-017-0695-6

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