Biochemical predictors of death before discharge in cooled newborns following perinatal asphyxia
Aim To analyse biochemical markers as possible predictors of death before discharge in cooled newborns following perinatal asphyxia. Methods A total of 91 infants that underwent therapeutic hypothermia after perinatal asphyxia were included. Inclusion criteria for therapeutic hypothermia were Sarna...
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| Format: | Article |
| Language: | English |
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Medical Association of Zenica-Doboj Canton
2022-08-01
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| Series: | Medicinski Glasnik |
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| Online Access: | https://ljkzedo.ba/mgpdf/mg37/04_Terzic_1447_A.pdf |
| _version_ | 1797739253092843520 |
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| author | Sabina Terzić Emina Vukas-Salihbegović Verica Mišanović Nedim Begić |
| author_facet | Sabina Terzić Emina Vukas-Salihbegović Verica Mišanović Nedim Begić |
| author_sort | Sabina Terzić |
| collection | DOAJ |
| description | Aim To analyse biochemical markers as possible predictors of death before discharge in cooled newborns following perinatal asphyxia.
Methods A total of 91 infants that underwent therapeutic hypothermia after perinatal asphyxia were included. Inclusion criteria for therapeutic hypothermia were Sarnat stage 2 or 3. Data were collected from medical histories regarding gender, gestational age, birth weight, Apgar and Sarnat score; additionally, gas analyses, liver and cardiac enzymes before, and in the first 12 hours after starting therapeutic hypothermia, were evaluated. The patients’ characteristics were compared between two groups, survivors and non-survivors.
Results Statistical difference was not found between groups regarding gender, gestational age, birth weight, delivery type, 1st and 5th minute Apgar score, seizures, alanine aminotransferase (ALT), creatine kinase (CK), troponin and fibrinogen level. Groups were significantly different regarding acid-base balance (p=0.012), base excess (BE) (p=0.025), lactate (p=0.002), aspartate aminotransferaze (AST), (p=0.011), lactate dehydrogenase (LDH) (p=0.006), activated partial thromboplastin clotting time (aPTT) (p=0.001) and international normalized ratio (INR) (p=0.001).
Conclusion Acid-base balance, BE, lactate, AST, LDH, aPTT and INR were significantly higher in the group of cooled newborns after perinatal asphyxia (non-survivors), and can serve as predictors of death before discharge. Combining diagnostic modalities raises a chance for accurate prediction of outcomes of asphyxiated infants. |
| first_indexed | 2024-03-12T13:55:34Z |
| format | Article |
| id | doaj.art-180afd2b0b72483f9d8e6b853f4bf7b7 |
| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-03-12T13:55:34Z |
| publishDate | 2022-08-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
| record_format | Article |
| series | Medicinski Glasnik |
| spelling | doaj.art-180afd2b0b72483f9d8e6b853f4bf7b72023-08-22T15:27:12ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452022-08-0119217818310.17392/1447-22Biochemical predictors of death before discharge in cooled newborns following perinatal asphyxiaSabina Terzić0Emina Vukas-Salihbegović1Verica Mišanović2Nedim Begić3Paediatric Clinic, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and HerzegovinaPaediatric Clinic, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and HerzegovinaPaediatric Clinic, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and HerzegovinaPaediatric Clinic, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and HerzegovinaAim To analyse biochemical markers as possible predictors of death before discharge in cooled newborns following perinatal asphyxia. Methods A total of 91 infants that underwent therapeutic hypothermia after perinatal asphyxia were included. Inclusion criteria for therapeutic hypothermia were Sarnat stage 2 or 3. Data were collected from medical histories regarding gender, gestational age, birth weight, Apgar and Sarnat score; additionally, gas analyses, liver and cardiac enzymes before, and in the first 12 hours after starting therapeutic hypothermia, were evaluated. The patients’ characteristics were compared between two groups, survivors and non-survivors. Results Statistical difference was not found between groups regarding gender, gestational age, birth weight, delivery type, 1st and 5th minute Apgar score, seizures, alanine aminotransferase (ALT), creatine kinase (CK), troponin and fibrinogen level. Groups were significantly different regarding acid-base balance (p=0.012), base excess (BE) (p=0.025), lactate (p=0.002), aspartate aminotransferaze (AST), (p=0.011), lactate dehydrogenase (LDH) (p=0.006), activated partial thromboplastin clotting time (aPTT) (p=0.001) and international normalized ratio (INR) (p=0.001). Conclusion Acid-base balance, BE, lactate, AST, LDH, aPTT and INR were significantly higher in the group of cooled newborns after perinatal asphyxia (non-survivors), and can serve as predictors of death before discharge. Combining diagnostic modalities raises a chance for accurate prediction of outcomes of asphyxiated infants.https://ljkzedo.ba/mgpdf/mg37/04_Terzic_1447_A.pdfhypoxiabiochemistrytreatment |
| spellingShingle | Sabina Terzić Emina Vukas-Salihbegović Verica Mišanović Nedim Begić Biochemical predictors of death before discharge in cooled newborns following perinatal asphyxia Medicinski Glasnik hypoxia biochemistry treatment |
| title | Biochemical predictors of death before discharge in cooled newborns following perinatal asphyxia |
| title_full | Biochemical predictors of death before discharge in cooled newborns following perinatal asphyxia |
| title_fullStr | Biochemical predictors of death before discharge in cooled newborns following perinatal asphyxia |
| title_full_unstemmed | Biochemical predictors of death before discharge in cooled newborns following perinatal asphyxia |
| title_short | Biochemical predictors of death before discharge in cooled newborns following perinatal asphyxia |
| title_sort | biochemical predictors of death before discharge in cooled newborns following perinatal asphyxia |
| topic | hypoxia biochemistry treatment |
| url | https://ljkzedo.ba/mgpdf/mg37/04_Terzic_1447_A.pdf |
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