Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes

Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes

Abstract Background Rheumatoid arthritis is a progressive and systemic autoimmune disease seriously compromises human health. Fibroblast like synoviocytes are the major effectors of proliferation and inflammation in rheumatoid arthritis synovial tissue. Shikonin has anti-inflammatory and immunomodul...

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Bibliographic Details
Main Authors: Lianhua He, Huijie Luan, Juan He, Miaomiao Zhang, Qingxia Qin, Yiping Hu, Yueming Cai, Desheng Sun, Yu Shi, Qingwen Wang
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Chinese Medicine
Subjects:
Shikonin
Collagen-induced arthritis
suppressor of cytokine signaling 1
Fibroblast-like synovial cells
Online Access:https://doi.org/10.1186/s13020-021-00510-6

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