The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China
Abstract Background Overweight/obesity can affect fertility, increase the risk of pregnancy complications, and affect the outcome of assisted reproductive technology (ART). However, due to confounding factors, the accuracy and uniformity of published findings on IVF outcomes have been disputed. This...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Reproductive Health |
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| Online Access: | https://doi.org/10.1186/s12978-022-01558-9 |
| _version_ | 1797958620800876544 |
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| author | Xiang Liu Shengjia Shi Jianhua Sun Yuan He Zhou Zhang Junping Xing Tie Chong |
| author_facet | Xiang Liu Shengjia Shi Jianhua Sun Yuan He Zhou Zhang Junping Xing Tie Chong |
| author_sort | Xiang Liu |
| collection | DOAJ |
| description | Abstract Background Overweight/obesity can affect fertility, increase the risk of pregnancy complications, and affect the outcome of assisted reproductive technology (ART). However, due to confounding factors, the accuracy and uniformity of published findings on IVF outcomes have been disputed. This study aimed to assess the effects of both male and female body mass index (BMI), individually and in combination, on IVF outcomes. Methods This retrospective cohort study included 11,191 couples undergoing IVF. Per the Chinese BMI standard, the couples were divided into four groups: normal; female overweight/obesity; male overweight/obesity; and combined male and female overweight/obesity. The IVF outcomes of the four groups were compared and analysed. Results Regarding the 6569 first fresh IVF-ET cycles, compared with the normal weight group, the female overweight/obesity and combined male/female overweight/obesity groups had much lower numbers of available embryos and high-quality embryos (p < 0.05); additionally, the fertilization (p < 0.001) and normal fertilization rates (p < 0.001) were significantly decreased in the female overweight/obesity group. The combined male/female overweight/obesity group had significant reductions in the available embryo (p = 0.002), high-quality embryo (p = 0.010), fertilization (p = 0.001) and normal fertilization rates (p < 0.001); however, neither male or female overweight/obesity nor their combination significantly affected the clinical pregnancy rate (CPR), live birth rate (LBR) or abortion rate (p > 0.05). Conclusion Our findings support the notion that overweight/obesity does not influence pregnancy success; however, we found that overweight/obesity affects the fertilization rate and embryo number and that there are sex differences. |
| first_indexed | 2024-04-11T00:21:31Z |
| format | Article |
| id | doaj.art-180cdd40627343c3ab35ac5691f15d5a |
| institution | Directory Open Access Journal |
| issn | 1742-4755 |
| language | English |
| last_indexed | 2024-04-11T00:21:31Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Health |
| spelling | doaj.art-180cdd40627343c3ab35ac5691f15d5a2023-01-08T12:13:30ZengBMCReproductive Health1742-47552023-01-0120111010.1186/s12978-022-01558-9The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western ChinaXiang Liu0Shengjia Shi1Jianhua Sun2Yuan He3Zhou Zhang4Junping Xing5Tie Chong6The Second Affiliated Hospital of Xi’an Jiao Tong UniversityReproductive Center of Northwest Women’s and Children’s HospitalReproductive Center of Northwest Women’s and Children’s HospitalReproductive Center of Northwest Women’s and Children’s HospitalReproductive Center of Northwest Women’s and Children’s HospitalThe First Affiliated Hospital of Xi’an Jiao Tong UniversityThe Second Affiliated Hospital of Xi’an Jiao Tong UniversityAbstract Background Overweight/obesity can affect fertility, increase the risk of pregnancy complications, and affect the outcome of assisted reproductive technology (ART). However, due to confounding factors, the accuracy and uniformity of published findings on IVF outcomes have been disputed. This study aimed to assess the effects of both male and female body mass index (BMI), individually and in combination, on IVF outcomes. Methods This retrospective cohort study included 11,191 couples undergoing IVF. Per the Chinese BMI standard, the couples were divided into four groups: normal; female overweight/obesity; male overweight/obesity; and combined male and female overweight/obesity. The IVF outcomes of the four groups were compared and analysed. Results Regarding the 6569 first fresh IVF-ET cycles, compared with the normal weight group, the female overweight/obesity and combined male/female overweight/obesity groups had much lower numbers of available embryos and high-quality embryos (p < 0.05); additionally, the fertilization (p < 0.001) and normal fertilization rates (p < 0.001) were significantly decreased in the female overweight/obesity group. The combined male/female overweight/obesity group had significant reductions in the available embryo (p = 0.002), high-quality embryo (p = 0.010), fertilization (p = 0.001) and normal fertilization rates (p < 0.001); however, neither male or female overweight/obesity nor their combination significantly affected the clinical pregnancy rate (CPR), live birth rate (LBR) or abortion rate (p > 0.05). Conclusion Our findings support the notion that overweight/obesity does not influence pregnancy success; however, we found that overweight/obesity affects the fertilization rate and embryo number and that there are sex differences.https://doi.org/10.1186/s12978-022-01558-9Overweight/obesityBMIIn vitro fertilization-embryo transfer (IVF-ET)CPRLBR |
| spellingShingle | Xiang Liu Shengjia Shi Jianhua Sun Yuan He Zhou Zhang Junping Xing Tie Chong The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China Reproductive Health Overweight/obesity BMI In vitro fertilization-embryo transfer (IVF-ET) CPR LBR |
| title | The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China |
| title_full | The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China |
| title_fullStr | The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China |
| title_full_unstemmed | The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China |
| title_short | The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China |
| title_sort | influence of male and female overweight obesity on ivf outcomes a cohort study based on registration in western china |
| topic | Overweight/obesity BMI In vitro fertilization-embryo transfer (IVF-ET) CPR LBR |
| url | https://doi.org/10.1186/s12978-022-01558-9 |
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