Cellular metabolism and homeostasis in pluripotency regulation
Abstract Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate, and they possess unique metabolic characteristics that facilitate pluripotency regulation. Here, we review recent progress in understanding the mechanisms that link cellular metabolism and hom...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2020-07-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13238-020-00755-1 |
| _version_ | 1827852176353918976 |
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| author | Kun Liu Jiani Cao Xingxing Shi Liang Wang Tongbiao Zhao |
| author_facet | Kun Liu Jiani Cao Xingxing Shi Liang Wang Tongbiao Zhao |
| author_sort | Kun Liu |
| collection | DOAJ |
| description | Abstract Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate, and they possess unique metabolic characteristics that facilitate pluripotency regulation. Here, we review recent progress in understanding the mechanisms that link cellular metabolism and homeostasis to pluripotency regulation, with particular emphasis on pathways involving amino acid metabolism, lipid metabolism, the ubiquitin-proteasome system and autophagy. Metabolism of amino acids and lipids is tightly coupled to epigenetic modification, organelle remodeling and cell signaling pathways for pluripotency regulation. PSCs harness enhanced proteasome and autophagy activity to meet the material and energy requirements for cellular homeostasis. These regulatory events reflect a fine balance between the intrinsic cellular requirements and the extrinsic environment. A more complete understanding of this balance will pave new ways to manipulate PSC fate. |
| first_indexed | 2024-03-12T10:46:14Z |
| format | Article |
| id | doaj.art-180eb0f878b448b5b5ed3ef72d0197b4 |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T10:46:14Z |
| publishDate | 2020-07-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-180eb0f878b448b5b5ed3ef72d0197b42023-09-02T07:28:43ZengOxford University PressProtein & Cell1674-800X1674-80182020-07-0111963064010.1007/s13238-020-00755-1Cellular metabolism and homeostasis in pluripotency regulationKun Liu0Jiani Cao1Xingxing Shi2Liang Wang3Tongbiao Zhao4State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesAbstract Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate, and they possess unique metabolic characteristics that facilitate pluripotency regulation. Here, we review recent progress in understanding the mechanisms that link cellular metabolism and homeostasis to pluripotency regulation, with particular emphasis on pathways involving amino acid metabolism, lipid metabolism, the ubiquitin-proteasome system and autophagy. Metabolism of amino acids and lipids is tightly coupled to epigenetic modification, organelle remodeling and cell signaling pathways for pluripotency regulation. PSCs harness enhanced proteasome and autophagy activity to meet the material and energy requirements for cellular homeostasis. These regulatory events reflect a fine balance between the intrinsic cellular requirements and the extrinsic environment. A more complete understanding of this balance will pave new ways to manipulate PSC fate.https://doi.org/10.1007/s13238-020-00755-1autophagyamino acid metabolismlipid metabolismpluripotent stem cell (PSC)ubiquitin-proteasome system (UPS) |
| spellingShingle | Kun Liu Jiani Cao Xingxing Shi Liang Wang Tongbiao Zhao Cellular metabolism and homeostasis in pluripotency regulation Protein & Cell autophagy amino acid metabolism lipid metabolism pluripotent stem cell (PSC) ubiquitin-proteasome system (UPS) |
| title | Cellular metabolism and homeostasis in pluripotency regulation |
| title_full | Cellular metabolism and homeostasis in pluripotency regulation |
| title_fullStr | Cellular metabolism and homeostasis in pluripotency regulation |
| title_full_unstemmed | Cellular metabolism and homeostasis in pluripotency regulation |
| title_short | Cellular metabolism and homeostasis in pluripotency regulation |
| title_sort | cellular metabolism and homeostasis in pluripotency regulation |
| topic | autophagy amino acid metabolism lipid metabolism pluripotent stem cell (PSC) ubiquitin-proteasome system (UPS) |
| url | https://doi.org/10.1007/s13238-020-00755-1 |
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