In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing mice
Bioactivities of fucoidan, a class of marine algal polysaccharides, vary depending on the original algal species. The aim of this study was to explore the in vivo immunomodulatory activity of fucoidan from Undaria pinnatifida, a brown alga with a long history of medicinal and food uses in East Asia,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623000865 |
| _version_ | 1797869809743953920 |
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| author | Qin Li Xiaoyan Wang Yisheng Wan Xianmin Hu Juan Liu Jun Wang |
| author_facet | Qin Li Xiaoyan Wang Yisheng Wan Xianmin Hu Juan Liu Jun Wang |
| author_sort | Qin Li |
| collection | DOAJ |
| description | Bioactivities of fucoidan, a class of marine algal polysaccharides, vary depending on the original algal species. The aim of this study was to explore the in vivo immunomodulatory activity of fucoidan from Undaria pinnatifida, a brown alga with a long history of medicinal and food uses in East Asia, in sarcoma 180 (S180) subcutaneous xenograft-bearing mice. Results showed that oral administration of fucoidan significantly enhanced the phagocytotic function of mononuclear phagocytic system, increased the serum levels of Th1 cytokines interleukin-2, interferon-γ and tumor necrosis factor-α, promoted spleen T lymphocyte responses, increased the infiltration of CD11c + dendritic cells (DCs) into transplanted sarcoma tissues, and upregulated the surface expression of MHC class II and costimulatory molecule CD86 on bone marrow-derived CD11c+ DCs in S180-bearing mice. Overall, fucoidan from Undaria pinnatifida represents an antitumor adjuvant stimulating both innate and adaptive immune responses for patients with advanced soft tissue sarcomas. |
| first_indexed | 2024-04-10T00:17:37Z |
| format | Article |
| id | doaj.art-180f7137948243a89d68e1cdfe3f89e9 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T00:17:37Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-180f7137948243a89d68e1cdfe3f89e92023-03-16T05:03:35ZengElsevierJournal of Functional Foods1756-46462023-04-01103105486In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing miceQin Li0Xiaoyan Wang1Yisheng Wan2Xianmin Hu3Juan Liu4Jun Wang5Institute of Pharmaceutical Innovation, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, ChinaInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaInstitute of Pharmaceutical Innovation, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, ChinaInstitute of Pharmaceutical Innovation, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, ChinaInstitute of Pharmaceutical Innovation, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, ChinaInstitute of Pharmaceutical Innovation, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China; Corresponding author.Bioactivities of fucoidan, a class of marine algal polysaccharides, vary depending on the original algal species. The aim of this study was to explore the in vivo immunomodulatory activity of fucoidan from Undaria pinnatifida, a brown alga with a long history of medicinal and food uses in East Asia, in sarcoma 180 (S180) subcutaneous xenograft-bearing mice. Results showed that oral administration of fucoidan significantly enhanced the phagocytotic function of mononuclear phagocytic system, increased the serum levels of Th1 cytokines interleukin-2, interferon-γ and tumor necrosis factor-α, promoted spleen T lymphocyte responses, increased the infiltration of CD11c + dendritic cells (DCs) into transplanted sarcoma tissues, and upregulated the surface expression of MHC class II and costimulatory molecule CD86 on bone marrow-derived CD11c+ DCs in S180-bearing mice. Overall, fucoidan from Undaria pinnatifida represents an antitumor adjuvant stimulating both innate and adaptive immune responses for patients with advanced soft tissue sarcomas.http://www.sciencedirect.com/science/article/pii/S1756464623000865FucoidanUndaria pinnatifidaSarcoma 180ImmunomodulationDendritic cells |
| spellingShingle | Qin Li Xiaoyan Wang Yisheng Wan Xianmin Hu Juan Liu Jun Wang In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing mice Journal of Functional Foods Fucoidan Undaria pinnatifida Sarcoma 180 Immunomodulation Dendritic cells |
| title | In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing mice |
| title_full | In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing mice |
| title_fullStr | In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing mice |
| title_full_unstemmed | In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing mice |
| title_short | In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing mice |
| title_sort | in vivo immunomodulatory activity of fucoidan from brown alga undaria pinnatifida in sarcoma 180 bearing mice |
| topic | Fucoidan Undaria pinnatifida Sarcoma 180 Immunomodulation Dendritic cells |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623000865 |
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