TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy
Xenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to induce downstream activation of TBK1 signalling and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14533-4 |
| _version_ | 1818980477342580736 |
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| author | Takashi Nozawa Shunsuke Sano Atsuko Minowa-Nozawa Hirotaka Toh Shintaro Nakajima Kazunori Murase Chihiro Aikawa Ichiro Nakagawa |
| author_facet | Takashi Nozawa Shunsuke Sano Atsuko Minowa-Nozawa Hirotaka Toh Shintaro Nakajima Kazunori Murase Chihiro Aikawa Ichiro Nakagawa |
| author_sort | Takashi Nozawa |
| collection | DOAJ |
| description | Xenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to induce downstream activation of TBK1 signalling and xenophagy, as well as mitophagy. |
| first_indexed | 2024-12-20T17:16:03Z |
| format | Article |
| id | doaj.art-181094b3d4dc4048b7968139d1016659 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T17:16:03Z |
| publishDate | 2020-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-181094b3d4dc4048b7968139d10166592022-12-21T19:32:00ZengNature PortfolioNature Communications2041-17232020-02-0111111610.1038/s41467-020-14533-4TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagyTakashi Nozawa0Shunsuke Sano1Atsuko Minowa-Nozawa2Hirotaka Toh3Shintaro Nakajima4Kazunori Murase5Chihiro Aikawa6Ichiro Nakagawa7Department of Microbiology, Graduate School of Medicine, Kyoto UniversityDepartment of Microbiology, Graduate School of Medicine, Kyoto UniversityDepartment of Microbiology, Graduate School of Medicine, Kyoto UniversityDepartment of Microbiology, Graduate School of Medicine, Kyoto UniversityDepartment of Life Science Dentistry, The Nippon Dental UniversityDepartment of Microbiology, Graduate School of Medicine, Kyoto UniversityDepartment of Microbiology, Graduate School of Medicine, Kyoto UniversityDepartment of Microbiology, Graduate School of Medicine, Kyoto UniversityXenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to induce downstream activation of TBK1 signalling and xenophagy, as well as mitophagy.https://doi.org/10.1038/s41467-020-14533-4 |
| spellingShingle | Takashi Nozawa Shunsuke Sano Atsuko Minowa-Nozawa Hirotaka Toh Shintaro Nakajima Kazunori Murase Chihiro Aikawa Ichiro Nakagawa TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy Nature Communications |
| title | TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy |
| title_full | TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy |
| title_fullStr | TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy |
| title_full_unstemmed | TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy |
| title_short | TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy |
| title_sort | tbc1d9 regulates tbk1 activation through ca2 signaling in selective autophagy |
| url | https://doi.org/10.1038/s41467-020-14533-4 |
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