A potential adverse role for leptin and cardiac leptin receptor in the right ventricle in pulmonary arterial hypertension: effect of metformin is BMPR2 mutation-specific

A potential adverse role for leptin and cardiac leptin receptor in the right ventricle in pulmonary arterial hypertension: effect of metformin is BMPR2 mutation-specific

IntroductionPulmonary arterial hypertension is a fatal cardiopulmonary disease. Leptin, a neuroendocrine hormone released by adipose tissue, has a complex relationship with cardiovascular diseases, including PAH. Leptin is thought to be an important factor linking metabolic syndrome and cardiovascul...

Full description

Bibliographic Details
Main Authors: Megha Talati, Evan Brittain, Vineet Agrawal, Niki Fortune, Katie Simon, Sheila Shay, Xiaofang Zeng, Michael L. Freeman, James West, Anna Hemnes
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Medicine
Subjects:
pulmonary arterial hypertension
BMPR2 mutation
right ventricular dysfunction
RV lipotoxicity
leptin and leptin receptors
H9c2 cultured cardiomyocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1276422/full

Similar Items

Similar Items