Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition of the nasal and paranasal tissues, characterized by the presence of bilateral nasal polyps. While etiology and pathogenetic mechanisms are heterogeneous and complex, in most patients, disease is mediated predominantly th...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455124000176 |
| _version_ | 1797253954522841088 |
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| author | Jorge F. Maspero, MD Wilma Anselmo-Lima, MD David Bedoya, MD Marcos Alejandro Jimenez Chobillón, MD Javier Ospina, MD Renato Roithmann, MD Andrés Sadek Gonzalez, MD Ricardo Silva Rueda, MD |
| author_facet | Jorge F. Maspero, MD Wilma Anselmo-Lima, MD David Bedoya, MD Marcos Alejandro Jimenez Chobillón, MD Javier Ospina, MD Renato Roithmann, MD Andrés Sadek Gonzalez, MD Ricardo Silva Rueda, MD |
| author_sort | Jorge F. Maspero, MD |
| collection | DOAJ |
| description | Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition of the nasal and paranasal tissues, characterized by the presence of bilateral nasal polyps. While etiology and pathogenetic mechanisms are heterogeneous and complex, in most patients, disease is mediated predominantly through type 2 inflammatory processes. Clinical management is challenging, and a multidisciplinary approach is preferred. Principal treatment approaches are the use of local/systemic corticosteroids and sinonasal surgery, although outcomes can be unsatisfactory. Recent availability of biological therapies targeting underlying inflammatory processes can offer effective treatment options in uncontrolled disease. Specialist guidelines greatly assist clinical decision-making, although as these are chiefly written from a global/international perspective, they may not wholly accommodate disease patterns and clinical practice at a regional level. An expert panel of specialists from Latin America was convened to develop regional guidance on the management of CRSwNP through a consensus approach. The present article presents the chief observations and recommendations which can provide guidance for clinicians in the Latin American region. |
| first_indexed | 2024-03-07T14:29:43Z |
| format | Article |
| id | doaj.art-18142be564b54aa0b4f321dbea554eef |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-04-24T21:42:16Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-18142be564b54aa0b4f321dbea554eef2024-03-21T05:36:15ZengElsevierWorld Allergy Organization Journal1939-45512024-03-01173100886Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working groupJorge F. Maspero, MD0Wilma Anselmo-Lima, MD1David Bedoya, MD2Marcos Alejandro Jimenez Chobillón, MD3Javier Ospina, MD4Renato Roithmann, MD5Andrés Sadek Gonzalez, MD6Ricardo Silva Rueda, MD7Fundación CIDEA, Buenos Aires, Argentina; Corresponding author. Fundación CIDEA, Buenos Aires, ArgentinaRibeirao Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, BrazilDepartment of Otorhinolaryngology, Universidad de Antioquia, Medellin, ColombiaNational Institute for Respiratory Diseases, Mexico City, MexicoDivision of Otolaryngology - Sinus and Skull Base Surgery, Fundación Santa Fe de Bogotá, Bogotá, ColombiaUniversidade Luterana do Brasil, Faculdade de Medicina, Porto Alegre, RS, BrazilHospital Angeles del Pedregal, Camino a Santa Teresa 1055, Delegacion Alvaro Obregon, CP10700 Mexico City, MexicoDepartment of Otorhinolaryngology, Hospital Militar Central, Bogotá, ColombiaChronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition of the nasal and paranasal tissues, characterized by the presence of bilateral nasal polyps. While etiology and pathogenetic mechanisms are heterogeneous and complex, in most patients, disease is mediated predominantly through type 2 inflammatory processes. Clinical management is challenging, and a multidisciplinary approach is preferred. Principal treatment approaches are the use of local/systemic corticosteroids and sinonasal surgery, although outcomes can be unsatisfactory. Recent availability of biological therapies targeting underlying inflammatory processes can offer effective treatment options in uncontrolled disease. Specialist guidelines greatly assist clinical decision-making, although as these are chiefly written from a global/international perspective, they may not wholly accommodate disease patterns and clinical practice at a regional level. An expert panel of specialists from Latin America was convened to develop regional guidance on the management of CRSwNP through a consensus approach. The present article presents the chief observations and recommendations which can provide guidance for clinicians in the Latin American region.http://www.sciencedirect.com/science/article/pii/S1939455124000176BiologicsChronic rhinosinusitis with nasal polyposisCRSwNPType 2 inflammation |
| spellingShingle | Jorge F. Maspero, MD Wilma Anselmo-Lima, MD David Bedoya, MD Marcos Alejandro Jimenez Chobillón, MD Javier Ospina, MD Renato Roithmann, MD Andrés Sadek Gonzalez, MD Ricardo Silva Rueda, MD Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group World Allergy Organization Journal Biologics Chronic rhinosinusitis with nasal polyposis CRSwNP Type 2 inflammation |
| title | Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group |
| title_full | Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group |
| title_fullStr | Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group |
| title_full_unstemmed | Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group |
| title_short | Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group |
| title_sort | management of crswnp in latin america a multidisciplinary consensus from an expert working group |
| topic | Biologics Chronic rhinosinusitis with nasal polyposis CRSwNP Type 2 inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1939455124000176 |
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