The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples
BackgroundAdipokine dysregulation is a key feature of insulin resistance and a metabolic syndrome associated with obesity. Low adiponectin levels are associated with higher risks of cardiovascular diseases (CVD). However, high adiponectin levels have also been associated with increased all-cause and...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.805244/full |
| _version_ | 1798035424042549248 |
|---|---|
| author | Jun Muratsu Jun Muratsu Kei Kamide Kei Kamide Takashi Fujimoto Yasushi Takeya Yasushi Takeya Ken Sugimoto Yoshiaki Taniyama Atsuyuki Morishima Katsuhiko Sakaguchi Yuji Matsuzawa Hiromi Rakugi |
| author_facet | Jun Muratsu Jun Muratsu Kei Kamide Kei Kamide Takashi Fujimoto Yasushi Takeya Yasushi Takeya Ken Sugimoto Yoshiaki Taniyama Atsuyuki Morishima Katsuhiko Sakaguchi Yuji Matsuzawa Hiromi Rakugi |
| author_sort | Jun Muratsu |
| collection | DOAJ |
| description | BackgroundAdipokine dysregulation is a key feature of insulin resistance and a metabolic syndrome associated with obesity. Low adiponectin levels are associated with higher risks of cardiovascular diseases (CVD). However, high adiponectin levels have also been associated with increased all-cause and cardiovascular mortality in the elderly. This adiponectin paradox has yet to be clarified, which has hindered our understanding of the biological role of adiponectin. Adipokine dysregulation and insulin resistance are also associated with energy-deprivation conditions, such as frailty in old age. The objective of this study was to investigate the association between plasma adiponectin and insulin resistance using the homeostasis model assessment for insulin resistance (HOMA-IR) classified by age. In particular, we sought to determine the factors of the subjects associated with both high adiponectin levels and HOMA-IR (H-adiponectin/H-HOMA) and high adiponectin levels and low HOMA-IR (H-adiponectin/L-HOMA).MethodsThe eligible subjects in this cross-sectional study were 33,216 individuals who had undergone health checkups at the Physical Checkup Center of Sumitomo Hospital between April 2008 and December 2018. After excluding 26,371 individuals who were under 60 years old, 529 who had been taking medications for diabetes mellitus, and 690 with missing data, the present study included 5,673 (3,467 males, 2,206 females) subjects with no missing data. The relationship between serum adiponectin levels and HOMA-IR was assessed using logistic regression models adjusted by clinically relevant factors.ResultsIn the multivariable logistic regression analysis, age and low BMI were shown to positively correlate with the characteristics of H-adiponectin/H-HOMA. In females, systolic blood pressure was also shown to be an associated factor.ConclusionIn conclusion, this study showed that aging or a low BMI may contribute to high adiponectin levels and insulin resistance. |
| first_indexed | 2024-04-11T20:58:00Z |
| format | Article |
| id | doaj.art-1814ea1fae8b47f39e6baefac997611e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T20:58:00Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1814ea1fae8b47f39e6baefac997611e2022-12-22T04:03:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-01-011210.3389/fendo.2021.805244805244The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old PeoplesJun Muratsu0Jun Muratsu1Kei Kamide2Kei Kamide3Takashi Fujimoto4Yasushi Takeya5Yasushi Takeya6Ken Sugimoto7Yoshiaki Taniyama8Atsuyuki Morishima9Katsuhiko Sakaguchi10Yuji Matsuzawa11Hiromi Rakugi12Department of Nephrology and Hypertension, Sumitomo Hospital, Osaka, JapanDepartment of Nephrology, Rinku General Medical Center, Izumisano City, JapanDivision of Health Sciences, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, JapanDepartment of Nephrology and Hypertension, Sumitomo Hospital, Osaka, JapanDivision of Health Sciences, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, JapanDepartment of General and Geriatric Medicine, Kawasaki Medical School General Medical Center, Okayama, JapanDepartment of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, JapanDepartment of Nephrology and Hypertension, Sumitomo Hospital, Osaka, JapanDepartment of Nephrology and Hypertension, Sumitomo Hospital, Osaka, JapanDepartment of Nephrology and Hypertension, Sumitomo Hospital, Osaka, JapanDepartment of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, JapanBackgroundAdipokine dysregulation is a key feature of insulin resistance and a metabolic syndrome associated with obesity. Low adiponectin levels are associated with higher risks of cardiovascular diseases (CVD). However, high adiponectin levels have also been associated with increased all-cause and cardiovascular mortality in the elderly. This adiponectin paradox has yet to be clarified, which has hindered our understanding of the biological role of adiponectin. Adipokine dysregulation and insulin resistance are also associated with energy-deprivation conditions, such as frailty in old age. The objective of this study was to investigate the association between plasma adiponectin and insulin resistance using the homeostasis model assessment for insulin resistance (HOMA-IR) classified by age. In particular, we sought to determine the factors of the subjects associated with both high adiponectin levels and HOMA-IR (H-adiponectin/H-HOMA) and high adiponectin levels and low HOMA-IR (H-adiponectin/L-HOMA).MethodsThe eligible subjects in this cross-sectional study were 33,216 individuals who had undergone health checkups at the Physical Checkup Center of Sumitomo Hospital between April 2008 and December 2018. After excluding 26,371 individuals who were under 60 years old, 529 who had been taking medications for diabetes mellitus, and 690 with missing data, the present study included 5,673 (3,467 males, 2,206 females) subjects with no missing data. The relationship between serum adiponectin levels and HOMA-IR was assessed using logistic regression models adjusted by clinically relevant factors.ResultsIn the multivariable logistic regression analysis, age and low BMI were shown to positively correlate with the characteristics of H-adiponectin/H-HOMA. In females, systolic blood pressure was also shown to be an associated factor.ConclusionIn conclusion, this study showed that aging or a low BMI may contribute to high adiponectin levels and insulin resistance.https://www.frontiersin.org/articles/10.3389/fendo.2021.805244/fulladiponectininsulin resistanceagingbody mass indexold peoples |
| spellingShingle | Jun Muratsu Jun Muratsu Kei Kamide Kei Kamide Takashi Fujimoto Yasushi Takeya Yasushi Takeya Ken Sugimoto Yoshiaki Taniyama Atsuyuki Morishima Katsuhiko Sakaguchi Yuji Matsuzawa Hiromi Rakugi The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples Frontiers in Endocrinology adiponectin insulin resistance aging body mass index old peoples |
| title | The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples |
| title_full | The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples |
| title_fullStr | The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples |
| title_full_unstemmed | The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples |
| title_short | The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples |
| title_sort | combination of high levels of adiponectin and insulin resistance are affected by aging in non obese old peoples |
| topic | adiponectin insulin resistance aging body mass index old peoples |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.805244/full |
| work_keys_str_mv | AT junmuratsu thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT junmuratsu thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT keikamide thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT keikamide thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT takashifujimoto thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT yasushitakeya thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT yasushitakeya thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT kensugimoto thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT yoshiakitaniyama thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT atsuyukimorishima thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT katsuhikosakaguchi thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT yujimatsuzawa thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT hiromirakugi thecombinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT junmuratsu combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT junmuratsu combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT keikamide combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT keikamide combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT takashifujimoto combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT yasushitakeya combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT yasushitakeya combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT kensugimoto combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT yoshiakitaniyama combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT atsuyukimorishima combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT katsuhikosakaguchi combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT yujimatsuzawa combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples AT hiromirakugi combinationofhighlevelsofadiponectinandinsulinresistanceareaffectedbyaginginnonobeseoldpeoples |