Deletion of Vaccinia Virus A40R Gene Improves the Immunogenicity of the HIV-1 Vaccine Candidate MVA-B

Deletion of Vaccinia Virus A40R Gene Improves the Immunogenicity of the HIV-1 Vaccine Candidate MVA-B

Development of a safe and efficacious vaccine against the HIV/AIDS pandemic remains a major scientific goal. We previously described an HIV/AIDS vaccine based on the modified vaccinia virus Ankara (MVA) expressing HIV-1 gp120 and Gag-Pol-Nef (GPN) of clade B (termed MVA-B), which showed moderate imm...

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Bibliographic Details
Main Authors: Patricia Pérez, María Q. Marín, Adrián Lázaro-Frías, Carlos Óscar S. Sorzano, Carmen E. Gómez, Mariano Esteban, Juan García-Arriaza
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Vaccines
Subjects:
<i>a40r</i> gene
poxvirus
mva
hiv vaccine
mice
immune responses
Online Access:https://www.mdpi.com/2076-393X/8/1/70

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