Prognostic Role of Pretreatment C-Reactive Protein to Albumin Ratio in Urological Cancers: A Systematic Review and Meta-Analysis
BackgroundTo investigate the potential prognostic role of C-reactive protein to albumin ratio (CAR) in patients with urinary cancers, including renal cell carcinoma (RCC), bladder cancer (BC), and prostate cancer (PC).MethodsWe searched and screened literatures with PubMed, Embase, Cochrane Library,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.879803/full |
| _version_ | 1819023839350226944 |
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| author | Minhong Wu Yan Zhou Qingsheng Chen Zhiling Yu Hongyong Gu Pengxiu Lin Yanling Li Cailing Liu |
| author_facet | Minhong Wu Yan Zhou Qingsheng Chen Zhiling Yu Hongyong Gu Pengxiu Lin Yanling Li Cailing Liu |
| author_sort | Minhong Wu |
| collection | DOAJ |
| description | BackgroundTo investigate the potential prognostic role of C-reactive protein to albumin ratio (CAR) in patients with urinary cancers, including renal cell carcinoma (RCC), bladder cancer (BC), and prostate cancer (PC).MethodsWe searched and screened literatures with PubMed, Embase, Cochrane Library, and Web of Science in January 2022. We applied combined hazard ratios (HRs) and 95% confidence intervals (CIs) to assess the associations.ResultsThirteen studies including 2,941 cases were analyzed in our study. Merged results indicated that highly pretreated CAR was associated with inferior overall survival (HR 2.21, 95% CI 1.86-2.62, p < 0.001) and progression-free survival (HR 1.85, 95% CI 1.36-2.52, p < 0.001) for urinary cancers. In a subgroup analysis of OS by tumor type, CAR can be a predictor in RCC (HR 2.10, 95% CI 1.72-2.56), BC (HR 3.35, 95% CI 1.94-5.80), and PC (HR 2.20, 95% CI 1.43-3.37). In a subgroup analysis of PFS by tumor type, CAR can be a predictor in BC (HR 1.76, 95% CI 1.03-3.02), and RCC (HR 1.90, 95% CI 1.25-2.89). The reliability and robustness of results were confirmed.ConclusionsHigh pretreated CAR was effective predictor of poor survival in patients with urinary cancers and can act as prognostic factor for these cases.Systematic Review RegistrationPROSPERO (CRD42022306414). |
| first_indexed | 2024-12-21T04:45:16Z |
| format | Article |
| id | doaj.art-18180632d1bf4050bf65f3117e21fa79 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T04:45:16Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-18180632d1bf4050bf65f3117e21fa792022-12-21T19:15:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.879803879803Prognostic Role of Pretreatment C-Reactive Protein to Albumin Ratio in Urological Cancers: A Systematic Review and Meta-AnalysisMinhong Wu0Yan Zhou1Qingsheng Chen2Zhiling Yu3Hongyong Gu4Pengxiu Lin5Yanling Li6Cailing Liu7Department of Urology, Yichun People’s Hospital, Yichun, ChinaDepartment of Nursing, Wanzai County Traditional Chinese Medicine Hospital, Yichun, ChinaDepartment of Urology, Yichun People’s Hospital, Yichun, ChinaDepartment of Urology, Yichun People’s Hospital, Yichun, ChinaDepartment of Urology, Yichun People’s Hospital, Yichun, ChinaDepartment of Urology, Yichun People’s Hospital, Yichun, ChinaDepartment of Urology, Yichun People’s Hospital, Yichun, ChinaDepartment of Urology, Yichun People’s Hospital, Yichun, ChinaBackgroundTo investigate the potential prognostic role of C-reactive protein to albumin ratio (CAR) in patients with urinary cancers, including renal cell carcinoma (RCC), bladder cancer (BC), and prostate cancer (PC).MethodsWe searched and screened literatures with PubMed, Embase, Cochrane Library, and Web of Science in January 2022. We applied combined hazard ratios (HRs) and 95% confidence intervals (CIs) to assess the associations.ResultsThirteen studies including 2,941 cases were analyzed in our study. Merged results indicated that highly pretreated CAR was associated with inferior overall survival (HR 2.21, 95% CI 1.86-2.62, p < 0.001) and progression-free survival (HR 1.85, 95% CI 1.36-2.52, p < 0.001) for urinary cancers. In a subgroup analysis of OS by tumor type, CAR can be a predictor in RCC (HR 2.10, 95% CI 1.72-2.56), BC (HR 3.35, 95% CI 1.94-5.80), and PC (HR 2.20, 95% CI 1.43-3.37). In a subgroup analysis of PFS by tumor type, CAR can be a predictor in BC (HR 1.76, 95% CI 1.03-3.02), and RCC (HR 1.90, 95% CI 1.25-2.89). The reliability and robustness of results were confirmed.ConclusionsHigh pretreated CAR was effective predictor of poor survival in patients with urinary cancers and can act as prognostic factor for these cases.Systematic Review RegistrationPROSPERO (CRD42022306414).https://www.frontiersin.org/articles/10.3389/fonc.2022.879803/fullurological cancerC-reactive proteinalbuminprognosismeta-analysis |
| spellingShingle | Minhong Wu Yan Zhou Qingsheng Chen Zhiling Yu Hongyong Gu Pengxiu Lin Yanling Li Cailing Liu Prognostic Role of Pretreatment C-Reactive Protein to Albumin Ratio in Urological Cancers: A Systematic Review and Meta-Analysis Frontiers in Oncology urological cancer C-reactive protein albumin prognosis meta-analysis |
| title | Prognostic Role of Pretreatment C-Reactive Protein to Albumin Ratio in Urological Cancers: A Systematic Review and Meta-Analysis |
| title_full | Prognostic Role of Pretreatment C-Reactive Protein to Albumin Ratio in Urological Cancers: A Systematic Review and Meta-Analysis |
| title_fullStr | Prognostic Role of Pretreatment C-Reactive Protein to Albumin Ratio in Urological Cancers: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prognostic Role of Pretreatment C-Reactive Protein to Albumin Ratio in Urological Cancers: A Systematic Review and Meta-Analysis |
| title_short | Prognostic Role of Pretreatment C-Reactive Protein to Albumin Ratio in Urological Cancers: A Systematic Review and Meta-Analysis |
| title_sort | prognostic role of pretreatment c reactive protein to albumin ratio in urological cancers a systematic review and meta analysis |
| topic | urological cancer C-reactive protein albumin prognosis meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.879803/full |
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