Ca2+ dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide

Ca2+ dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide

Abstract Background Cardiac mesenchymal stromal cells (C-MSC) were recently shown to differentiate into adipocytes and myofibroblasts to promote the aberrant remodeling of cardiac tissue that characterizes arrhythmogenic cardiomyopathy (ACM). A calcium (Ca2+) signaling dysfunction, mainly demonstrat...

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Bibliographic Details
Main Authors: Angela S. Maione, Pawan Faris, Lara Iengo, Valentina Catto, Luca Bisonni, Francesco Lodola, Sharon Negri, Michela Casella, Anna Guarino, Gianluca Polvani, Marina Cerrone, Claudio Tondo, Giulio Pompilio, Elena Sommariva, Francesco Moccia
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Translational Medicine
Subjects:
Arrhythmogenic cardiomyopathy
Cardiac mesenchymal stromal cells
Calcium signalling
CaMKII
Store-operated Ca2+ entry
Flecainide
Online Access:https://doi.org/10.1186/s12967-022-03742-8

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