Comparison of joint status using ultrasound assessments and Haemophilia Joint Health Score 2.1 in children with haemophilia
IntroductionUltrasound (US) has gained popularity in the evaluation of haemophilic joint diseases because it enables the imaging of soft-tissue lesions in the joints and bone-cartilage lesions. We aimed to determine the correlation between US evaluations and clinical assessments performed using HJHS...
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Frontiers Media S.A.
2023-07-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1193830/full |
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| author | Yanju Li Feiqing Wang Feiqing Wang Chengyun Pan Jing Zhang Qian Zhang Lingying Ban Lingling Song Jishi Wang Zhixu He Xiaojing Zeng Dongxin Tang Yang Liu Yang Liu |
| author_facet | Yanju Li Feiqing Wang Feiqing Wang Chengyun Pan Jing Zhang Qian Zhang Lingying Ban Lingling Song Jishi Wang Zhixu He Xiaojing Zeng Dongxin Tang Yang Liu Yang Liu |
| author_sort | Yanju Li |
| collection | DOAJ |
| description | IntroductionUltrasound (US) has gained popularity in the evaluation of haemophilic joint diseases because it enables the imaging of soft-tissue lesions in the joints and bone-cartilage lesions. We aimed to determine the correlation between US evaluations and clinical assessments performed using HJHS 2.1 and to evaluate their respective characteristics in assessing early haemophilic arthropathy.MethodsA total of 178 joints (32 knees, 85 elbows, and 61 ankles) in 45 haemophilia A patients (median age, 10 years; range, 6–15) were assessed using US and HJHS 2.1. Ultrasonographic scoring was performed in consensus assessments by one imager by using the US scores.ResultsThe total HJHS 2.1 and US scores showed a strong correlation (rS=0.651, P=0.000, CI: 0.553–0.763), with an excellent correlation for the elbows (rS=0.867, P=0.000, CI: 0.709–0.941) and a substantial correlation for the knees (rS=0.681, P=0.000, CI: 0.527–0.797). The correlation for the ankles was relatively moderate (rS=0.518, P=0.000, CI: 0.308–0.705). Nine subjects (15.5%) without abnormalities, as indicated by HJHS 2.1, showed haemophilic arthropathy in US scoring. All nine joints showed moderate (1/9) to severe (8/9) synovial thickening in the ankle (5/9) and elbow joints (4/9). In contrast, 50 joints (50.5%) showed normal US scores and abnormal changes as indicated by HJHS 2.1. S scores correlated well with HJHS 2.1 for overall and individual joints.DiscussionUS could identify some early pathological changes in joints showing normal clinical findings, but still cannot replace the HJHS; however, it can serve as an imaging examination complementing HJHS 2. |
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| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-12T23:09:18Z |
| publishDate | 2023-07-01 |
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| spelling | doaj.art-1818513a0c5e40f7a585f9e8702cdff32023-07-18T08:25:12ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-07-011010.3389/fmed.2023.11938301193830Comparison of joint status using ultrasound assessments and Haemophilia Joint Health Score 2.1 in children with haemophiliaYanju Li0Feiqing Wang1Feiqing Wang2Chengyun Pan3Jing Zhang4Qian Zhang5Lingying Ban6Lingling Song7Jishi Wang8Zhixu He9Xiaojing Zeng10Dongxin Tang11Yang Liu12Yang Liu13Department of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaClinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin City, ChinaDepartment of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaKey Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Medical University, Guiyang, ChinaDepartment of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaClinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaClinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaKey Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Medical University, Guiyang, ChinaIntroductionUltrasound (US) has gained popularity in the evaluation of haemophilic joint diseases because it enables the imaging of soft-tissue lesions in the joints and bone-cartilage lesions. We aimed to determine the correlation between US evaluations and clinical assessments performed using HJHS 2.1 and to evaluate their respective characteristics in assessing early haemophilic arthropathy.MethodsA total of 178 joints (32 knees, 85 elbows, and 61 ankles) in 45 haemophilia A patients (median age, 10 years; range, 6–15) were assessed using US and HJHS 2.1. Ultrasonographic scoring was performed in consensus assessments by one imager by using the US scores.ResultsThe total HJHS 2.1 and US scores showed a strong correlation (rS=0.651, P=0.000, CI: 0.553–0.763), with an excellent correlation for the elbows (rS=0.867, P=0.000, CI: 0.709–0.941) and a substantial correlation for the knees (rS=0.681, P=0.000, CI: 0.527–0.797). The correlation for the ankles was relatively moderate (rS=0.518, P=0.000, CI: 0.308–0.705). Nine subjects (15.5%) without abnormalities, as indicated by HJHS 2.1, showed haemophilic arthropathy in US scoring. All nine joints showed moderate (1/9) to severe (8/9) synovial thickening in the ankle (5/9) and elbow joints (4/9). In contrast, 50 joints (50.5%) showed normal US scores and abnormal changes as indicated by HJHS 2.1. S scores correlated well with HJHS 2.1 for overall and individual joints.DiscussionUS could identify some early pathological changes in joints showing normal clinical findings, but still cannot replace the HJHS; however, it can serve as an imaging examination complementing HJHS 2.https://www.frontiersin.org/articles/10.3389/fmed.2023.1193830/fullHaemophilia Joint Health Score (HJHS)haemophiliaarthropathyultrasonographychildren |
| spellingShingle | Yanju Li Feiqing Wang Feiqing Wang Chengyun Pan Jing Zhang Qian Zhang Lingying Ban Lingling Song Jishi Wang Zhixu He Xiaojing Zeng Dongxin Tang Yang Liu Yang Liu Comparison of joint status using ultrasound assessments and Haemophilia Joint Health Score 2.1 in children with haemophilia Frontiers in Medicine Haemophilia Joint Health Score (HJHS) haemophilia arthropathy ultrasonography children |
| title | Comparison of joint status using ultrasound assessments and Haemophilia Joint Health Score 2.1 in children with haemophilia |
| title_full | Comparison of joint status using ultrasound assessments and Haemophilia Joint Health Score 2.1 in children with haemophilia |
| title_fullStr | Comparison of joint status using ultrasound assessments and Haemophilia Joint Health Score 2.1 in children with haemophilia |
| title_full_unstemmed | Comparison of joint status using ultrasound assessments and Haemophilia Joint Health Score 2.1 in children with haemophilia |
| title_short | Comparison of joint status using ultrasound assessments and Haemophilia Joint Health Score 2.1 in children with haemophilia |
| title_sort | comparison of joint status using ultrasound assessments and haemophilia joint health score 2 1 in children with haemophilia |
| topic | Haemophilia Joint Health Score (HJHS) haemophilia arthropathy ultrasonography children |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1193830/full |
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