APOA1 (-75 G>A and 83 C>T) and APOB (2488 C>T) polymorphisms and their association with myocardial infarction, lipids and apolipoproteins in patients with type 2 diabetes mellitus
Introduction The increased risk of myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) is well documented. Polymorphisms in APOA1 and APOB genes allow us to identify new genetic markers in the Mexican population with T2DM and MI. Material and methods We studied 135 patients with DMT2 and...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-03-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/APOA1-75-G-A-and-83-C-T-and-APOB-2488-C-T-polymorphisms-and-their-association-with,108674,0,2.html |
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| author | Fidel Antonio Casillas Diana Emilia Martínez Fernández Yeminia Valle Maricela Aceves Ramírez Brenda Parra-Reyna Salvador Sarabia Pulido Cesar Manuel Guzmán Sánchez Héctor Enrique Flores Salinas Francisco Muñoz Valle Jorge Ramón Padilla Gutiérrez |
| author_facet | Fidel Antonio Casillas Diana Emilia Martínez Fernández Yeminia Valle Maricela Aceves Ramírez Brenda Parra-Reyna Salvador Sarabia Pulido Cesar Manuel Guzmán Sánchez Héctor Enrique Flores Salinas Francisco Muñoz Valle Jorge Ramón Padilla Gutiérrez |
| author_sort | Fidel Antonio Casillas |
| collection | DOAJ |
| description | Introduction
The increased risk of myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) is well documented. Polymorphisms in APOA1 and APOB genes allow us to identify new genetic markers in the Mexican population with T2DM and MI.
Material and methods
We studied 135 patients with DMT2 and MI (DI); another 85 non-infarcted diabetic individuals with DMT2 but without previous ischemic events (NID) and 242 healthy subjects (HS). All three groups were selected with the aim to investigate the association between the polymorphisms and infarction when T2DM is present or absent.
Results
-75 G>A polymorphism: Differences were found in genotype distribution between DI and NID individuals (OR = 2.01, 95% CI: 1.117–3.623, p = 0.019) with an increased risk for A in the dominant model (OR = 1.77, 95% CI: 1.020–3.084, p = 0.042); also concentrations of ApoA-I for A/A were lower in comparison with G/A (p = 0.038) and LDL-C and HDL-C levels were lower in G/A compared to G/G carriers. 83 C>T polymorphism of APOA1: For DI individuals, HDL-C was lower in T/T compared to C/C and triglyceride levels were lower in C/T compared to C/C carriers.
Conclusions
The -75 G>A APOA1 polymorphism could be considered as a susceptibility factor for myocardial infarction in individuals with T2DM and 2488 C>T APOB polymorphism is associated with changes in HDL-C and LDL-C and triglycerides in the same group. |
| first_indexed | 2024-03-09T10:46:08Z |
| format | Article |
| id | doaj.art-1819248d23c847a1b5d3062e345c5fdb |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:46:08Z |
| publishDate | 2021-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-1819248d23c847a1b5d3062e345c5fdb2023-12-01T09:59:22ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512021-03-011861438144510.5114/aoms/108674108674APOA1 (-75 G>A and 83 C>T) and APOB (2488 C>T) polymorphisms and their association with myocardial infarction, lipids and apolipoproteins in patients with type 2 diabetes mellitusFidel Antonio Casillas0Diana Emilia Martínez Fernández1Yeminia Valle2Maricela Aceves Ramírez3Brenda Parra-Reyna4Salvador Sarabia Pulido5Cesar Manuel Guzmán Sánchez6Héctor Enrique Flores Salinas7Francisco Muñoz Valle8Jorge Ramón Padilla Gutiérrez9Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Guadalajara, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Guadalajara, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Guadalajara, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Guadalajara, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Guadalajara, MexicoEspecialidad en Cardiología, Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente (CMNO), Guadalajara, Jalisco, MexicoEspecialidad en Cardiología, Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente (CMNO), Guadalajara, Jalisco, MexicoEspecialidad en Cardiología, Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente (CMNO), Guadalajara, Jalisco, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Guadalajara, MexicoInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Guadalajara, MexicoIntroduction The increased risk of myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) is well documented. Polymorphisms in APOA1 and APOB genes allow us to identify new genetic markers in the Mexican population with T2DM and MI. Material and methods We studied 135 patients with DMT2 and MI (DI); another 85 non-infarcted diabetic individuals with DMT2 but without previous ischemic events (NID) and 242 healthy subjects (HS). All three groups were selected with the aim to investigate the association between the polymorphisms and infarction when T2DM is present or absent. Results -75 G>A polymorphism: Differences were found in genotype distribution between DI and NID individuals (OR = 2.01, 95% CI: 1.117–3.623, p = 0.019) with an increased risk for A in the dominant model (OR = 1.77, 95% CI: 1.020–3.084, p = 0.042); also concentrations of ApoA-I for A/A were lower in comparison with G/A (p = 0.038) and LDL-C and HDL-C levels were lower in G/A compared to G/G carriers. 83 C>T polymorphism of APOA1: For DI individuals, HDL-C was lower in T/T compared to C/C and triglyceride levels were lower in C/T compared to C/C carriers. Conclusions The -75 G>A APOA1 polymorphism could be considered as a susceptibility factor for myocardial infarction in individuals with T2DM and 2488 C>T APOB polymorphism is associated with changes in HDL-C and LDL-C and triglycerides in the same group.https://www.archivesofmedicalscience.com/APOA1-75-G-A-and-83-C-T-and-APOB-2488-C-T-polymorphisms-and-their-association-with,108674,0,2.htmlmyocardial infarctionlipidsapolipoproteinstype 2 diabetes mellitus |
| spellingShingle | Fidel Antonio Casillas Diana Emilia Martínez Fernández Yeminia Valle Maricela Aceves Ramírez Brenda Parra-Reyna Salvador Sarabia Pulido Cesar Manuel Guzmán Sánchez Héctor Enrique Flores Salinas Francisco Muñoz Valle Jorge Ramón Padilla Gutiérrez APOA1 (-75 G>A and 83 C>T) and APOB (2488 C>T) polymorphisms and their association with myocardial infarction, lipids and apolipoproteins in patients with type 2 diabetes mellitus Archives of Medical Science myocardial infarction lipids apolipoproteins type 2 diabetes mellitus |
| title | APOA1 (-75 G>A and 83 C>T) and APOB (2488 C>T) polymorphisms and their association with myocardial infarction, lipids and apolipoproteins in patients with type 2 diabetes mellitus |
| title_full | APOA1 (-75 G>A and 83 C>T) and APOB (2488 C>T) polymorphisms and their association with myocardial infarction, lipids and apolipoproteins in patients with type 2 diabetes mellitus |
| title_fullStr | APOA1 (-75 G>A and 83 C>T) and APOB (2488 C>T) polymorphisms and their association with myocardial infarction, lipids and apolipoproteins in patients with type 2 diabetes mellitus |
| title_full_unstemmed | APOA1 (-75 G>A and 83 C>T) and APOB (2488 C>T) polymorphisms and their association with myocardial infarction, lipids and apolipoproteins in patients with type 2 diabetes mellitus |
| title_short | APOA1 (-75 G>A and 83 C>T) and APOB (2488 C>T) polymorphisms and their association with myocardial infarction, lipids and apolipoproteins in patients with type 2 diabetes mellitus |
| title_sort | apoa1 75 g a and 83 c t and apob 2488 c t polymorphisms and their association with myocardial infarction lipids and apolipoproteins in patients with type 2 diabetes mellitus |
| topic | myocardial infarction lipids apolipoproteins type 2 diabetes mellitus |
| url | https://www.archivesofmedicalscience.com/APOA1-75-G-A-and-83-C-T-and-APOB-2488-C-T-polymorphisms-and-their-association-with,108674,0,2.html |
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