Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case report
Neonatal purpura fulminans (PF) is a rare, life-threatening condition, caused by congenital or acquired deficiencies of protein C or S. PF describes a clinico-pathological entity of dermal microvascular thrombosis associated with disseminated intravascular coagulation (DIC) and perivascular hemorrha...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-07-01
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| Series: | Journal of Dermatology and Dermatologic Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352241016300275 |
| _version_ | 1818505971511590912 |
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| author | Sultan A. Jafarri Khalid M. AlAttas Sultan M. Bajawi Mohammad K. Ahsan Ali M. Al-Sheikh Mohammed A. Buraik Amr Mohammed Gamal Nadia S. Mustafa |
| author_facet | Sultan A. Jafarri Khalid M. AlAttas Sultan M. Bajawi Mohammad K. Ahsan Ali M. Al-Sheikh Mohammed A. Buraik Amr Mohammed Gamal Nadia S. Mustafa |
| author_sort | Sultan A. Jafarri |
| collection | DOAJ |
| description | Neonatal purpura fulminans (PF) is a rare, life-threatening condition, caused by congenital or acquired deficiencies of protein C or S. PF describes a clinico-pathological entity of dermal microvascular thrombosis associated with disseminated intravascular coagulation (DIC) and perivascular hemorrhage occurring in the newborn period. Here we describe a newborn with PF due to severe congenital protein C deficiency. The lesions started 5 h after birth but the infant was brought to our emergency department 20 h later. The infant was admitted in neonatal intensive care unit (NICU) and treated with fresh frozen plasma (FFP), enoxaparin along with other supportive cares. In spite of impressive improvement of skin lesions, coordination with numerous subspecialties and aggressive NICU support, the infant died one month after admission due to multiorgan failure and septicaemia. |
| first_indexed | 2024-12-10T21:58:07Z |
| format | Article |
| id | doaj.art-181beee716554973a824aa89bc6d1049 |
| institution | Directory Open Access Journal |
| issn | 2352-2410 |
| language | English |
| last_indexed | 2024-12-10T21:58:07Z |
| publishDate | 2017-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Dermatology and Dermatologic Surgery |
| spelling | doaj.art-181beee716554973a824aa89bc6d10492022-12-22T01:31:59ZengWolters Kluwer Medknow PublicationsJournal of Dermatology and Dermatologic Surgery2352-24102017-07-0121210410610.1016/j.jdds.2016.10.001Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case reportSultan A. Jafarri0Khalid M. AlAttas1Sultan M. Bajawi2Mohammad K. Ahsan3Ali M. Al-Sheikh4Mohammed A. Buraik5Amr Mohammed Gamal6Nadia S. Mustafa7Department of Dermatology, King Fahad Central Hospital, Jizan, Saudi ArabiaDepartment of Dermatology, King Fahad Central Hospital, Jizan, Saudi ArabiaDepartment of Dermatology, King Fahad Central Hospital, Jizan, Saudi ArabiaDepartment of Dermatology, King Fahad Central Hospital, Jizan, Saudi ArabiaDepartment of Dermatology, King Fahad Central Hospital, Jizan, Saudi ArabiaDepartment of Dermatology, King Fahad Central Hospital, Jizan, Saudi ArabiaDepartment of Dermatology, King Fahad Central Hospital, Jizan, Saudi ArabiaDepartment of Dermatology, King Fahad Central Hospital, Jizan, Saudi ArabiaNeonatal purpura fulminans (PF) is a rare, life-threatening condition, caused by congenital or acquired deficiencies of protein C or S. PF describes a clinico-pathological entity of dermal microvascular thrombosis associated with disseminated intravascular coagulation (DIC) and perivascular hemorrhage occurring in the newborn period. Here we describe a newborn with PF due to severe congenital protein C deficiency. The lesions started 5 h after birth but the infant was brought to our emergency department 20 h later. The infant was admitted in neonatal intensive care unit (NICU) and treated with fresh frozen plasma (FFP), enoxaparin along with other supportive cares. In spite of impressive improvement of skin lesions, coordination with numerous subspecialties and aggressive NICU support, the infant died one month after admission due to multiorgan failure and septicaemia.http://www.sciencedirect.com/science/article/pii/S2352241016300275NeonatalPurpura fulminansCongenitalProtein C deficiency |
| spellingShingle | Sultan A. Jafarri Khalid M. AlAttas Sultan M. Bajawi Mohammad K. Ahsan Ali M. Al-Sheikh Mohammed A. Buraik Amr Mohammed Gamal Nadia S. Mustafa Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case report Journal of Dermatology and Dermatologic Surgery Neonatal Purpura fulminans Congenital Protein C deficiency |
| title | Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case report |
| title_full | Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case report |
| title_fullStr | Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case report |
| title_full_unstemmed | Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case report |
| title_short | Neonatal purpura fulminans in newborn with severe congenital protein C deficiency: Case report |
| title_sort | neonatal purpura fulminans in newborn with severe congenital protein c deficiency case report |
| topic | Neonatal Purpura fulminans Congenital Protein C deficiency |
| url | http://www.sciencedirect.com/science/article/pii/S2352241016300275 |
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