Simultaneous inference of haplotypes and alleles at a causal gene
We present a new methodology which jointly infers haplotypes and the causal alleles at a gene influencing a given trait. Often in human genetic studies, the available data consists of genotypes (series of genetic markers along the chromosomes) and a phenotype. However, for many genetic analyses, one...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00291/full |
| _version_ | 1828397731638411264 |
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| author | Fabrice eLarribe Mathieu J Dupont Gabrielle eBoucher |
| author_facet | Fabrice eLarribe Mathieu J Dupont Gabrielle eBoucher |
| author_sort | Fabrice eLarribe |
| collection | DOAJ |
| description | We present a new methodology which jointly infers haplotypes and the causal alleles at a gene influencing a given trait. Often in human genetic studies, the available data consists of genotypes (series of genetic markers along the chromosomes) and a phenotype. However, for many genetic analyses, one needs haplotypes instead of genotypes. Our methodology is not only able to estimate haplotypes conditionally on the disease status, but is also able to infer the alleles at the unknown disease locus. Some applications of our methodology are in genetic mapping and in genetic counselling. |
| first_indexed | 2024-12-10T08:52:32Z |
| format | Article |
| id | doaj.art-181d5473dab44329aeee03fafc9c6ae4 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T08:52:32Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-181d5473dab44329aeee03fafc9c6ae42022-12-22T01:55:33ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-10-01610.3389/fgene.2015.00291136915Simultaneous inference of haplotypes and alleles at a causal geneFabrice eLarribe0Mathieu J Dupont1Gabrielle eBoucher2Université du Québec à MontréalUniversité de MontréalMontreal Heart InstituteWe present a new methodology which jointly infers haplotypes and the causal alleles at a gene influencing a given trait. Often in human genetic studies, the available data consists of genotypes (series of genetic markers along the chromosomes) and a phenotype. However, for many genetic analyses, one needs haplotypes instead of genotypes. Our methodology is not only able to estimate haplotypes conditionally on the disease status, but is also able to infer the alleles at the unknown disease locus. Some applications of our methodology are in genetic mapping and in genetic counselling.http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00291/fullLinkage DisequilibriumEM algorithmCase-Control StudiesHaplotype estimationcausal allele inference |
| spellingShingle | Fabrice eLarribe Mathieu J Dupont Gabrielle eBoucher Simultaneous inference of haplotypes and alleles at a causal gene Frontiers in Genetics Linkage Disequilibrium EM algorithm Case-Control Studies Haplotype estimation causal allele inference |
| title | Simultaneous inference of haplotypes and alleles at a causal gene |
| title_full | Simultaneous inference of haplotypes and alleles at a causal gene |
| title_fullStr | Simultaneous inference of haplotypes and alleles at a causal gene |
| title_full_unstemmed | Simultaneous inference of haplotypes and alleles at a causal gene |
| title_short | Simultaneous inference of haplotypes and alleles at a causal gene |
| title_sort | simultaneous inference of haplotypes and alleles at a causal gene |
| topic | Linkage Disequilibrium EM algorithm Case-Control Studies Haplotype estimation causal allele inference |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00291/full |
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