Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro
Mortality from liver disease conditions continues to be very high. As liver diseases manifest and progress silently, prompt measures after diagnosis are essential in the treatment of these conditions. Microfluidic organs-on-chip platforms have significant potential for the study of the pathophysiolo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/13/3/428 |
| _version_ | 1797444830501011456 |
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| author | Perizat Kanabekova Adina Kadyrova Gulsim Kulsharova |
| author_facet | Perizat Kanabekova Adina Kadyrova Gulsim Kulsharova |
| author_sort | Perizat Kanabekova |
| collection | DOAJ |
| description | Mortality from liver disease conditions continues to be very high. As liver diseases manifest and progress silently, prompt measures after diagnosis are essential in the treatment of these conditions. Microfluidic organs-on-chip platforms have significant potential for the study of the pathophysiology of liver diseases in vitro. Different liver-on-a-chip microphysiological platforms have been reported to study cell-signaling pathways such as those activating stellate cells within liver diseases. Moreover, the drug efficacy for liver conditions might be evaluated on a cellular metabolic level. Here, we present a comprehensive review of microphysiological platforms used for modelling liver diseases. First, we briefly introduce the concept and importance of organs-on-a-chip in studying liver diseases in vitro, reflecting on existing reviews of healthy liver-on-a-chip platforms. Second, the techniques of cell cultures used in the microfluidic devices, including 2D, 3D, and spheroid cells, are explained. Next, the types of liver diseases (NAFLD, ALD, hepatitis infections, and drug injury) on-chip are explained for a further comprehensive overview of the design and methods of developing liver diseases in vitro. Finally, some challenges in design and existing solutions to them are reviewed |
| first_indexed | 2024-03-09T13:17:09Z |
| format | Article |
| id | doaj.art-181f8fcfccbb4aa4b464f711d08d5b2d |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T13:17:09Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-181f8fcfccbb4aa4b464f711d08d5b2d2023-11-30T21:34:01ZengMDPI AGMicromachines2072-666X2022-03-0113342810.3390/mi13030428Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In VitroPerizat Kanabekova0Adina Kadyrova1Gulsim Kulsharova2School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan 010000, KazakhstanDepartment of Biological Sciences, School of Sciences and Humanities, Nazarbayev University, Nur-Sultan 010000, KazakhstanSchool of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan 010000, KazakhstanMortality from liver disease conditions continues to be very high. As liver diseases manifest and progress silently, prompt measures after diagnosis are essential in the treatment of these conditions. Microfluidic organs-on-chip platforms have significant potential for the study of the pathophysiology of liver diseases in vitro. Different liver-on-a-chip microphysiological platforms have been reported to study cell-signaling pathways such as those activating stellate cells within liver diseases. Moreover, the drug efficacy for liver conditions might be evaluated on a cellular metabolic level. Here, we present a comprehensive review of microphysiological platforms used for modelling liver diseases. First, we briefly introduce the concept and importance of organs-on-a-chip in studying liver diseases in vitro, reflecting on existing reviews of healthy liver-on-a-chip platforms. Second, the techniques of cell cultures used in the microfluidic devices, including 2D, 3D, and spheroid cells, are explained. Next, the types of liver diseases (NAFLD, ALD, hepatitis infections, and drug injury) on-chip are explained for a further comprehensive overview of the design and methods of developing liver diseases in vitro. Finally, some challenges in design and existing solutions to them are reviewedhttps://www.mdpi.com/2072-666X/13/3/428organ-on-chipliver-on-chipliver diseasemicrofluidic devices |
| spellingShingle | Perizat Kanabekova Adina Kadyrova Gulsim Kulsharova Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro Micromachines organ-on-chip liver-on-chip liver disease microfluidic devices |
| title | Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro |
| title_full | Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro |
| title_fullStr | Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro |
| title_full_unstemmed | Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro |
| title_short | Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro |
| title_sort | microfluidic organ on a chip devices for liver disease modeling in vitro |
| topic | organ-on-chip liver-on-chip liver disease microfluidic devices |
| url | https://www.mdpi.com/2072-666X/13/3/428 |
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