Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet
<strong>Introduction:</strong> Diabetes is a metabolic disease, which is directly correlated with increased physical disabilities and muscle tissue damage. The present study aimed to investigate the anti-apoptotic effects of interval and continued training and crocin on diabetic rats. &l...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-09-01
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| Series: | Journal of Fasting and Health |
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| Online Access: | http://jnfh.mums.ac.ir/article_13261_fbd441cc1c8df313bcf4667a63696b46.pdf |
| _version_ | 1828405669795987456 |
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| author | Ali Moradi Seyed Ali Hosseini Masoud Nikbakht |
| author_facet | Ali Moradi Seyed Ali Hosseini Masoud Nikbakht |
| author_sort | Ali Moradi |
| collection | DOAJ |
| description | <strong>Introduction:</strong> Diabetes is a metabolic disease, which is directly correlated with increased physical disabilities and muscle tissue damage. The present study aimed to investigate the anti-apoptotic effects of interval and continued training and crocin on diabetic rats. <strong>Methods:</strong> In this study, 49 adult rats aged eight weeks with diabetes inducaed by a high-fat diet and venous injection of streptozotocin were randomly assigned to seven groups, including high-intensity interval training (HIIT), low-intensity continued training (LICT), HIIT with crocin consumption, LICT with crocin consumption, crocin consumption, sham, and control. The animals in the HIIT and LICT groups ran on a treadmill three sessions per week for eight weeks at the intensity of 80-85% and 50-55% of the maximum speed, respectively. The animals in the crocin consumption groups received 25 mg/kg of crocin weekly for eight weeks. <strong>Results:</strong> HIIT and LICT could significantly increase Bcl-2 and decrease Bax and p53, as well as the ratio of Bax and Bcl-2 (P≤0.05). In addition, crocin consumption could significantly increase Bcl-2 and decrease Bax (P≤0.05). Training with crocin consumption had interactive effects on the increase of Bcl-2 and decrease of p53 and ratio of Bax to Bcl-2 (P≤0.05). <strong>Conclusion:</strong> According to the results, continued and interval training along with the consumption of crocin exerted interactive anti-apoptotic effects on the rats with diabetes induced by a high- fat diet. |
| first_indexed | 2024-12-10T10:57:32Z |
| format | Article |
| id | doaj.art-181fa56d82bc42568dfe2c48a40d498f |
| institution | Directory Open Access Journal |
| issn | 2345-2587 2345-2587 |
| language | English |
| last_indexed | 2024-12-10T10:57:32Z |
| publishDate | 2019-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Fasting and Health |
| spelling | doaj.art-181fa56d82bc42568dfe2c48a40d498f2022-12-22T01:51:48ZengMashhad University of Medical SciencesJournal of Fasting and Health2345-25872345-25872019-09-017313013710.22038/jnfh.2019.39346.118613261Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat DietAli Moradi0Seyed Ali Hosseini1Masoud Nikbakht2Department of Sport Physiology, Shoushtar Branch, Islamic Azad University, Shoushtar, IranDepartment of Exercise Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, IranDepartment of Sport Physiology, University of Ahwaz, Ahwaz, Iran<strong>Introduction:</strong> Diabetes is a metabolic disease, which is directly correlated with increased physical disabilities and muscle tissue damage. The present study aimed to investigate the anti-apoptotic effects of interval and continued training and crocin on diabetic rats. <strong>Methods:</strong> In this study, 49 adult rats aged eight weeks with diabetes inducaed by a high-fat diet and venous injection of streptozotocin were randomly assigned to seven groups, including high-intensity interval training (HIIT), low-intensity continued training (LICT), HIIT with crocin consumption, LICT with crocin consumption, crocin consumption, sham, and control. The animals in the HIIT and LICT groups ran on a treadmill three sessions per week for eight weeks at the intensity of 80-85% and 50-55% of the maximum speed, respectively. The animals in the crocin consumption groups received 25 mg/kg of crocin weekly for eight weeks. <strong>Results:</strong> HIIT and LICT could significantly increase Bcl-2 and decrease Bax and p53, as well as the ratio of Bax and Bcl-2 (P≤0.05). In addition, crocin consumption could significantly increase Bcl-2 and decrease Bax (P≤0.05). Training with crocin consumption had interactive effects on the increase of Bcl-2 and decrease of p53 and ratio of Bax to Bcl-2 (P≤0.05). <strong>Conclusion:</strong> According to the results, continued and interval training along with the consumption of crocin exerted interactive anti-apoptotic effects on the rats with diabetes induced by a high- fat diet.http://jnfh.mums.ac.ir/article_13261_fbd441cc1c8df313bcf4667a63696b46.pdfInterval trainingContinued TrainingCrocinApoptosisDiabetes |
| spellingShingle | Ali Moradi Seyed Ali Hosseini Masoud Nikbakht Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet Journal of Fasting and Health Interval training Continued Training Crocin Apoptosis Diabetes |
| title | Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet |
| title_full | Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet |
| title_fullStr | Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet |
| title_full_unstemmed | Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet |
| title_short | Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet |
| title_sort | anti apoptotic effects of interval and continued training and crocin on the muscle tissue of the rats with type ii diabetes induced by a high fat diet |
| topic | Interval training Continued Training Crocin Apoptosis Diabetes |
| url | http://jnfh.mums.ac.ir/article_13261_fbd441cc1c8df313bcf4667a63696b46.pdf |
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