Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2005-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900030 |
| _version_ | 1827847548425994240 |
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| author | M Holzhausen LC Spolidorio N Vergnolle |
| author_facet | M Holzhausen LC Spolidorio N Vergnolle |
| author_sort | M Holzhausen |
| collection | DOAJ |
| description | Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis. |
| first_indexed | 2024-03-12T09:31:51Z |
| format | Article |
| id | doaj.art-181fd49f784c4e1d8cfd3a75a9b3c2dd |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T09:31:51Z |
| publishDate | 2005-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-181fd49f784c4e1d8cfd3a75a9b3c2dd2023-09-02T13:53:43ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602005-03-0110017718010.1590/S0074-02762005000900030Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitisM HolzhausenLC SpolidorioN VergnolleProteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900030proteaseactivated receptor-2alveolar bone lossinflammationhost responsePorphyromonas gingivalisperiodontitis |
| spellingShingle | M Holzhausen LC Spolidorio N Vergnolle Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis Memorias do Instituto Oswaldo Cruz protease activated receptor-2 alveolar bone loss inflammation host response Porphyromonas gingivalis periodontitis |
| title | Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis |
| title_full | Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis |
| title_fullStr | Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis |
| title_full_unstemmed | Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis |
| title_short | Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis |
| title_sort | role of protease activated receptor 2 in inflammation and its possible implications as a putative mediator of periodontitis |
| topic | protease activated receptor-2 alveolar bone loss inflammation host response Porphyromonas gingivalis periodontitis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900030 |
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