Mechanophysiological analysis of anorectal function using simulated feces in human subjects
Introduction: Defecation is a complex process that is difficult to study and analyze. Objectives: Here, we present new analytical tools to calculate frictional force and tension during expulsion of the Fecobionics simulated stool in human subjects. Methods: The 12-cm-long Fecobionics device containe...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123220301612 |
| _version_ | 1811271145741090816 |
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| author | Daming Sun Donghua Liao Ssu Chi Chen Cherry Wong Wing Wah Leung Kaori Futaba Tony Mak Simon Ng Hans Gregersen |
| author_facet | Daming Sun Donghua Liao Ssu Chi Chen Cherry Wong Wing Wah Leung Kaori Futaba Tony Mak Simon Ng Hans Gregersen |
| author_sort | Daming Sun |
| collection | DOAJ |
| description | Introduction: Defecation is a complex process that is difficult to study and analyze. Objectives: Here, we present new analytical tools to calculate frictional force and tension during expulsion of the Fecobionics simulated stool in human subjects. Methods: The 12-cm-long Fecobionics device contained pressure sensors, motion processor units for measurement of orientation and bending, and impedance rings for measurement of cross-sectional areas. Eight normal subjects defecated Fecobionics. The bending angle of the device, frictional force between the device and the surrounding tissue, and the stretch tensions were calculated. Results: The bending angle and pressures changed during expulsion with the maximum pressure recorded at the rear. The averaged circumferential tension, longitudinal tension and friction force in each subject were associated with the front-rear pressure difference (r > 0.7, p < 0.005). The peak circumferential tension, longitudinal tension, and friction force immediately before expulsion of the rear were significantly higher compared to when the front entered the anal canal (F = 164.7, p < 0.005; F = 152.1, p < 0.005; F = 71.4, p < 0.005; respectively.). Conclusion: This study shows that Fecobionics obtained reliable data under physiological conditions. Mechanical features such as frictional force and stretch tensions were assessable during Fecobionics expulsion. |
| first_indexed | 2024-04-12T22:14:52Z |
| format | Article |
| id | doaj.art-182058b25eec4d79b645925dff155ed8 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-04-12T22:14:52Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-182058b25eec4d79b645925dff155ed82022-12-22T03:14:33ZengElsevierJournal of Advanced Research2090-12322021-02-0128245254Mechanophysiological analysis of anorectal function using simulated feces in human subjectsDaming Sun0Donghua Liao1Ssu Chi Chen2Cherry Wong3Wing Wah Leung4Kaori Futaba5Tony Mak6Simon Ng7Hans Gregersen8School of Microelectronics and Communication Engineering, Chongqing University, Shapingba, Chongqing, 400044, ChinaMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Denmark; GIOME Academia, Department of Clinical Medicine, Aarhus University, DK-8200 Aarhus, DenmarkDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong KongDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong KongDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong KongDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong KongDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong KongDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong KongDepartment of Surgery, Clinical Sciences Bldg., Prince of Wales Hospital, Shatin, Hong Kong; California Medical Innovations Institute, USA; Corresponding author at: GIOME, Department of Surgery, Clinical Science Building, Suite 94006, Prince of Wales Hospital, 30 Ngan St., Shatin, Hong Kong.Introduction: Defecation is a complex process that is difficult to study and analyze. Objectives: Here, we present new analytical tools to calculate frictional force and tension during expulsion of the Fecobionics simulated stool in human subjects. Methods: The 12-cm-long Fecobionics device contained pressure sensors, motion processor units for measurement of orientation and bending, and impedance rings for measurement of cross-sectional areas. Eight normal subjects defecated Fecobionics. The bending angle of the device, frictional force between the device and the surrounding tissue, and the stretch tensions were calculated. Results: The bending angle and pressures changed during expulsion with the maximum pressure recorded at the rear. The averaged circumferential tension, longitudinal tension and friction force in each subject were associated with the front-rear pressure difference (r > 0.7, p < 0.005). The peak circumferential tension, longitudinal tension, and friction force immediately before expulsion of the rear were significantly higher compared to when the front entered the anal canal (F = 164.7, p < 0.005; F = 152.1, p < 0.005; F = 71.4, p < 0.005; respectively.). Conclusion: This study shows that Fecobionics obtained reliable data under physiological conditions. Mechanical features such as frictional force and stretch tensions were assessable during Fecobionics expulsion.http://www.sciencedirect.com/science/article/pii/S2090123220301612Anorectal physiologyExpulsionFecobionicsFriction forceTension |
| spellingShingle | Daming Sun Donghua Liao Ssu Chi Chen Cherry Wong Wing Wah Leung Kaori Futaba Tony Mak Simon Ng Hans Gregersen Mechanophysiological analysis of anorectal function using simulated feces in human subjects Journal of Advanced Research Anorectal physiology Expulsion Fecobionics Friction force Tension |
| title | Mechanophysiological analysis of anorectal function using simulated feces in human subjects |
| title_full | Mechanophysiological analysis of anorectal function using simulated feces in human subjects |
| title_fullStr | Mechanophysiological analysis of anorectal function using simulated feces in human subjects |
| title_full_unstemmed | Mechanophysiological analysis of anorectal function using simulated feces in human subjects |
| title_short | Mechanophysiological analysis of anorectal function using simulated feces in human subjects |
| title_sort | mechanophysiological analysis of anorectal function using simulated feces in human subjects |
| topic | Anorectal physiology Expulsion Fecobionics Friction force Tension |
| url | http://www.sciencedirect.com/science/article/pii/S2090123220301612 |
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