Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

Low-abundance regulatory peptides, including metabolically important gut hormones, have shown promising therapeutic potential. Here, we present a streamlined mass spectrometry-based platform for identifying and characterizing low-abundance regulatory peptides in humans. We demonstrate the clinical a...

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Bibliographic Details
Main Authors: Nicolai J. Wewer Albrechtsen, Daniel Hornburg, Reidar Albrechtsen, Berit Svendsen, Signe Toräng, Sara L. Jepsen, Rune E. Kuhre, Marie Hansen, Charlotte Janus, Andrea Floyd, Asger Lund, Tina Vilsbøll, Filip K. Knop, Henrik Vestergaard, Carolyn F. Deacon, Felix Meissner, Matthias Mann, Jens J. Holst, Bolette Hartmann
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:EBioMedicine
Subjects:
Gut hormones
GLP-1
Low-abundant peptides
Mass-spectrometry
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416301220

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