MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients
Fatty acids, such as medium-chain fatty acids (MCFAs) and short-chain fatty acids (SCFAs), both important components of a normal diet, have been reported to play a role in bone-related diseases such as rheumatoid arthritis (RA). However, the role of medium-chain triglycerides (MCTs) has not been inv...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/15/17/3719 |
| _version_ | 1797582030286880768 |
|---|---|
| author | Christina Heidt Jörn Pons-Kühnemann Ulrike Kämmerer Thorsten Marquardt Monika Reuss-Borst |
| author_facet | Christina Heidt Jörn Pons-Kühnemann Ulrike Kämmerer Thorsten Marquardt Monika Reuss-Borst |
| author_sort | Christina Heidt |
| collection | DOAJ |
| description | Fatty acids, such as medium-chain fatty acids (MCFAs) and short-chain fatty acids (SCFAs), both important components of a normal diet, have been reported to play a role in bone-related diseases such as rheumatoid arthritis (RA). However, the role of medium-chain triglycerides (MCTs) has not been investigated in RA to date. The aim of this study was to investigate the effect of supplementation of regular diet with MCT with and without fiber on disease activity as measured with the SDAI (Simplified Disease Activity Index) in RA patients. A total of 61 RA patients on stable drug treatment were randomly assigned to a twice-daily control regimen or to a twice-daily regimen of a formulation containing medium-chain triglycerides (MCTs) 30 g/day for 8 weeks followed by a second twice-daily regimen of combining MCT (30 g/day) plus fiber (30 g/day) for an additional 8 weeks. The control group received a formulation containing long-chain triglycerides (LCTs) instead of MCTs. The preliminary results showed a significant reduction in SDAI from baseline to week 16 in the test group and a significant increase in β-hydroxybutyrate (BHB) levels, while no improvement in SDAI was observed in the control group. |
| first_indexed | 2024-03-10T23:16:03Z |
| format | Article |
| id | doaj.art-1827eec85ad14da5836967062c0750c7 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T23:16:03Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1827eec85ad14da5836967062c0750c72023-11-19T08:38:10ZengMDPI AGNutrients2072-66432023-08-011517371910.3390/nu15173719MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA PatientsChristina Heidt0Jörn Pons-Kühnemann1Ulrike Kämmerer2Thorsten Marquardt3Monika Reuss-Borst4Faculty of Medicine, University of Muenster, 48149 Muenster, GermanyMedical Statistics, Institute of Medical Informatics, Justus Liebig University, 35392 Giessen, GermanyDepartment of Obstetrics and Gynaecology, University Hospital of Wuerzburg, 97080 Wuerzburg, GermanyDepartment of General Pediatrics, Metabolic Diseases, University of Muenster, Albert-Schweitzer-Campus, 48149 Muenster, GermanyHescuro Clinics Bad Bocklet, 97708 Bad Bocklet, GermanyFatty acids, such as medium-chain fatty acids (MCFAs) and short-chain fatty acids (SCFAs), both important components of a normal diet, have been reported to play a role in bone-related diseases such as rheumatoid arthritis (RA). However, the role of medium-chain triglycerides (MCTs) has not been investigated in RA to date. The aim of this study was to investigate the effect of supplementation of regular diet with MCT with and without fiber on disease activity as measured with the SDAI (Simplified Disease Activity Index) in RA patients. A total of 61 RA patients on stable drug treatment were randomly assigned to a twice-daily control regimen or to a twice-daily regimen of a formulation containing medium-chain triglycerides (MCTs) 30 g/day for 8 weeks followed by a second twice-daily regimen of combining MCT (30 g/day) plus fiber (30 g/day) for an additional 8 weeks. The control group received a formulation containing long-chain triglycerides (LCTs) instead of MCTs. The preliminary results showed a significant reduction in SDAI from baseline to week 16 in the test group and a significant increase in β-hydroxybutyrate (BHB) levels, while no improvement in SDAI was observed in the control group.https://www.mdpi.com/2072-6643/15/17/3719rheumatoid arthritismedium-chain triglyceridesfiberSimplified Disease Activity Indexβ-hydroxybutyrate |
| spellingShingle | Christina Heidt Jörn Pons-Kühnemann Ulrike Kämmerer Thorsten Marquardt Monika Reuss-Borst MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients Nutrients rheumatoid arthritis medium-chain triglycerides fiber Simplified Disease Activity Index β-hydroxybutyrate |
| title | MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients |
| title_full | MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients |
| title_fullStr | MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients |
| title_full_unstemmed | MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients |
| title_short | MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients |
| title_sort | mct induced ketosis and fiber in rheumatoid arthritis mikara study protocol and primary endpoint results of the double blind randomized controlled intervention study indicating effects on disease activity in ra patients |
| topic | rheumatoid arthritis medium-chain triglycerides fiber Simplified Disease Activity Index β-hydroxybutyrate |
| url | https://www.mdpi.com/2072-6643/15/17/3719 |
| work_keys_str_mv | AT christinaheidt mctinducedketosisandfiberinrheumatoidarthritismikarastudyprotocolandprimaryendpointresultsofthedoubleblindrandomizedcontrolledinterventionstudyindicatingeffectsondiseaseactivityinrapatients AT jornponskuhnemann mctinducedketosisandfiberinrheumatoidarthritismikarastudyprotocolandprimaryendpointresultsofthedoubleblindrandomizedcontrolledinterventionstudyindicatingeffectsondiseaseactivityinrapatients AT ulrikekammerer mctinducedketosisandfiberinrheumatoidarthritismikarastudyprotocolandprimaryendpointresultsofthedoubleblindrandomizedcontrolledinterventionstudyindicatingeffectsondiseaseactivityinrapatients AT thorstenmarquardt mctinducedketosisandfiberinrheumatoidarthritismikarastudyprotocolandprimaryendpointresultsofthedoubleblindrandomizedcontrolledinterventionstudyindicatingeffectsondiseaseactivityinrapatients AT monikareussborst mctinducedketosisandfiberinrheumatoidarthritismikarastudyprotocolandprimaryendpointresultsofthedoubleblindrandomizedcontrolledinterventionstudyindicatingeffectsondiseaseactivityinrapatients |