Characterisation of Modular Polyketide Synthases Designed to Make Pentaene Analogues of Amphotericin B

Characterisation of Modular Polyketide Synthases Designed to Make Pentaene Analogues of Amphotericin B

Glycosylated polyene macrolides are important antifungal agents that are produced by many actinomycete species. Development of new polyenes may deliver improved antibiotics. Here, <i>Streptomyces nodosus</i> was genetically re-programmed to synthesise pentaene analogues of the heptaene a...

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Bibliographic Details
Main Authors: Yuhao Song, Mark Hogan, Jimmy Muldoon, Paul Evans, Patrick Caffrey
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
glycosylated polyene macrolides
antifungal antibiotics
amphotericin B
modular polyketide synthase
synthetic biology
Online Access:https://www.mdpi.com/1420-3049/29/6/1396

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