The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate–High-Risk Pulmonary Embolism: Bo-NE-Experience
Ultrasound-accelerated thrombolysis (USAT) is an advanced interventional therapy for patients with intermediate–high-risk pulmonary embolism (PE) who deteriorated on anticoagulation or for high-risk patients for whom systemic thrombolysis is contraindicated. The aim of this study is to investigate t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/10/3459 |
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| author | Hani Al-Terki Andreas Mügge Michael Gotzmann Vedat Tiyerili Friederike Klein Marcus Franz Sven Möbius-Winkler Abdelrahman Elhakim |
| author_facet | Hani Al-Terki Andreas Mügge Michael Gotzmann Vedat Tiyerili Friederike Klein Marcus Franz Sven Möbius-Winkler Abdelrahman Elhakim |
| author_sort | Hani Al-Terki |
| collection | DOAJ |
| description | Ultrasound-accelerated thrombolysis (USAT) is an advanced interventional therapy for patients with intermediate–high-risk pulmonary embolism (PE) who deteriorated on anticoagulation or for high-risk patients for whom systemic thrombolysis is contraindicated. The aim of this study is to investigate the safety and efficacy of this therapy with a focus on the improvement of vital signs and laboratory parameters. Seventy-nine patients with intermediate–high-risk PE were treated with USAT from August 2020 to November 2022. The therapy significantly decreased the mean RV/LV ratio from 1.2 ± 0.22 to 0.9 ± 0.2 (<i>p</i> < 0.001) as well as the mean PAPs from 48.6 ± 11 to 30.1 ± 9.0 mmHg (<i>p</i> < 0.001). The respiratory and heart rate decreased significantly (<i>p</i> < 0.001). Serum creatinine decreased significantly from 1.0 ± 0.35 to 0.9 ± 0.3 (<i>p</i> < 0.001). There were 12 access-associated complications, which could be treated conservatively. One patient had haemothorax after the therapy and had to be operated on. USAT is an effective therapy for patients with intermediate–high-risk PE, with favourable hemodynamic, clinical, and laboratory outcomes. |
| first_indexed | 2024-03-11T03:37:09Z |
| format | Article |
| id | doaj.art-18286cf177f94a1a98277021bc73fe58 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:37:09Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-18286cf177f94a1a98277021bc73fe582023-11-18T01:53:23ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011210345910.3390/jcm12103459The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate–High-Risk Pulmonary Embolism: Bo-NE-ExperienceHani Al-Terki0Andreas Mügge1Michael Gotzmann2Vedat Tiyerili3Friederike Klein4Marcus Franz5Sven Möbius-Winkler6Abdelrahman Elhakim7Cardiology and Rhythmology Department, University Hospital St. Josef-Hospital Bochum, Ruhr University Bochum, Gudrunstraße 56, 44791 Bochum, GermanyCardiology and Rhythmology Department, University Hospital St. Josef-Hospital Bochum, Ruhr University Bochum, Gudrunstraße 56, 44791 Bochum, GermanyCardiology and Rhythmology Department, University Hospital St. Josef-Hospital Bochum, Ruhr University Bochum, Gudrunstraße 56, 44791 Bochum, GermanyCardiology and Rhythmology, St.-Johannes Hospital Dortmund, 44137 Dortmund, GermanyDepartment of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, GermanyDepartment of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, GermanyDepartment of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, GermanyCardiology Department, Schoen Hospital, 23730 Neustadt in Holstein, GermanyUltrasound-accelerated thrombolysis (USAT) is an advanced interventional therapy for patients with intermediate–high-risk pulmonary embolism (PE) who deteriorated on anticoagulation or for high-risk patients for whom systemic thrombolysis is contraindicated. The aim of this study is to investigate the safety and efficacy of this therapy with a focus on the improvement of vital signs and laboratory parameters. Seventy-nine patients with intermediate–high-risk PE were treated with USAT from August 2020 to November 2022. The therapy significantly decreased the mean RV/LV ratio from 1.2 ± 0.22 to 0.9 ± 0.2 (<i>p</i> < 0.001) as well as the mean PAPs from 48.6 ± 11 to 30.1 ± 9.0 mmHg (<i>p</i> < 0.001). The respiratory and heart rate decreased significantly (<i>p</i> < 0.001). Serum creatinine decreased significantly from 1.0 ± 0.35 to 0.9 ± 0.3 (<i>p</i> < 0.001). There were 12 access-associated complications, which could be treated conservatively. One patient had haemothorax after the therapy and had to be operated on. USAT is an effective therapy for patients with intermediate–high-risk PE, with favourable hemodynamic, clinical, and laboratory outcomes.https://www.mdpi.com/2077-0383/12/10/3459EKOS<sup>TM</sup>pulmonary embolismactilyseUSAT |
| spellingShingle | Hani Al-Terki Andreas Mügge Michael Gotzmann Vedat Tiyerili Friederike Klein Marcus Franz Sven Möbius-Winkler Abdelrahman Elhakim The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate–High-Risk Pulmonary Embolism: Bo-NE-Experience Journal of Clinical Medicine EKOS<sup>TM</sup> pulmonary embolism actilyse USAT |
| title | The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate–High-Risk Pulmonary Embolism: Bo-NE-Experience |
| title_full | The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate–High-Risk Pulmonary Embolism: Bo-NE-Experience |
| title_fullStr | The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate–High-Risk Pulmonary Embolism: Bo-NE-Experience |
| title_full_unstemmed | The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate–High-Risk Pulmonary Embolism: Bo-NE-Experience |
| title_short | The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate–High-Risk Pulmonary Embolism: Bo-NE-Experience |
| title_sort | safety and efficacy of ultrasound accelerated catheter directed thrombolysis in patients with intermediate high risk pulmonary embolism bo ne experience |
| topic | EKOS<sup>TM</sup> pulmonary embolism actilyse USAT |
| url | https://www.mdpi.com/2077-0383/12/10/3459 |
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