A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus”
Currently, only three phages that infect the medically important bacterium Clostridium difficile have been discussed by the International Committee of Viral Taxonomy (ICTV). They are all myoviruses, and have been assigned to the genus “phicd119likevirus”. An additional nine phages have since been d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-05-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/7/5/2534 |
| _version_ | 1818958921067397120 |
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| author | Katherine R. Hargreaves Martha R. J. Clokie |
| author_facet | Katherine R. Hargreaves Martha R. J. Clokie |
| author_sort | Katherine R. Hargreaves |
| collection | DOAJ |
| description | Currently, only three phages that infect the medically important bacterium Clostridium difficile have been discussed by the International Committee of Viral Taxonomy (ICTV). They are all myoviruses, and have been assigned to the genus “phicd119likevirus”. An additional nine phages have since been described in the literature with their genome data available. The Phicd119likevirus is named after the type species: the myovirus ΦCD119 which was the first C. difficile phage to be sequenced. The two additional myoviruses, ϕCD27 and φC2, also fall into this genus based on the similarity of their genome and morphological characteristics. The other nine phages have not been assigned to this genus, and four of them do not fit the criteria for the current taxonomic grouping. We have applied protein clustering analysis to determine their phylogenetic relationships. From these results we propose an additional myoviridae genus, that we term “phiMMP04likevirus”. |
| first_indexed | 2024-12-20T11:33:25Z |
| format | Article |
| id | doaj.art-1828a98195e34650816b7b41e00fcdb7 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-20T11:33:25Z |
| publishDate | 2015-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-1828a98195e34650816b7b41e00fcdb72022-12-21T19:42:11ZengMDPI AGViruses1999-49152015-05-01752534254110.3390/v7052534v7052534A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus”Katherine R. Hargreaves0Martha R. J. Clokie1Department of Infection, Immunity and Inflammation, University of Leicester, Leicestershire LE1 9HN, UKDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicestershire LE1 9HN, UKCurrently, only three phages that infect the medically important bacterium Clostridium difficile have been discussed by the International Committee of Viral Taxonomy (ICTV). They are all myoviruses, and have been assigned to the genus “phicd119likevirus”. An additional nine phages have since been described in the literature with their genome data available. The Phicd119likevirus is named after the type species: the myovirus ΦCD119 which was the first C. difficile phage to be sequenced. The two additional myoviruses, ϕCD27 and φC2, also fall into this genus based on the similarity of their genome and morphological characteristics. The other nine phages have not been assigned to this genus, and four of them do not fit the criteria for the current taxonomic grouping. We have applied protein clustering analysis to determine their phylogenetic relationships. From these results we propose an additional myoviridae genus, that we term “phiMMP04likevirus”.http://www.mdpi.com/1999-4915/7/5/2534bacteriophageClostridium difficiletaxonomyprotein clusteringSiphoviridaeMyoviridaesmall myovirusbacteriophage phylogeny |
| spellingShingle | Katherine R. Hargreaves Martha R. J. Clokie A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus” Viruses bacteriophage Clostridium difficile taxonomy protein clustering Siphoviridae Myoviridae small myovirus bacteriophage phylogeny |
| title | A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus” |
| title_full | A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus” |
| title_fullStr | A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus” |
| title_full_unstemmed | A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus” |
| title_short | A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus” |
| title_sort | taxonomic review of clostridium difficile phages and proposal of a novel genus phimmp04likevirus |
| topic | bacteriophage Clostridium difficile taxonomy protein clustering Siphoviridae Myoviridae small myovirus bacteriophage phylogeny |
| url | http://www.mdpi.com/1999-4915/7/5/2534 |
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