Polydopamine-assisted surface modification for orthopaedic implants
Along with the massive use of implants in orthopaedic surgeries in recent few decades, there has been a tremendous demand for the surface modification of the implants to avoid surgery failure and improve their function. Polydopamine (PDA), being able to adhere to almost all kinds of substrates and p...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-04-01
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| Series: | Journal of Orthopaedic Translation |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X19300439 |
| _version_ | 1811232578245492736 |
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| author | Luanluan Jia Fengxuan Han Huan Wang Caihong Zhu Qianping Guo Jiaying Li Zhongliang Zhao Qiang Zhang Xuesong Zhu Bin Li |
| author_facet | Luanluan Jia Fengxuan Han Huan Wang Caihong Zhu Qianping Guo Jiaying Li Zhongliang Zhao Qiang Zhang Xuesong Zhu Bin Li |
| author_sort | Luanluan Jia |
| collection | DOAJ |
| description | Along with the massive use of implants in orthopaedic surgeries in recent few decades, there has been a tremendous demand for the surface modification of the implants to avoid surgery failure and improve their function. Polydopamine (PDA), being able to adhere to almost all kinds of substrates and possessing copious functional groups for covalently immobilizing biomolecules and anchoring metal ions, has been widely used for surface modification of materials since its discovery in the last decade. PDA and its derivatives can be used for the surface modification of orthopaedic implants to modulate cellular responses, including cell spreading, migration, proliferation, and differentiation, and may thereby enhance the function of existing implants. In addition, the osseointegration and antimicrobial properties of orthopaedic implants may also be improved by PDA-based coatings. The aim of this review is to provide a brief overview of current advances of surface modification technologies for orthopaedic implants using PDA and its derivatives as a medium. Given the versatility of PDA-based adhesion, such PDA-assisted surface modification technologies will certainly benefit the development of new orthopaedic implants. The translational potential of this article: Surface treatments of orthopaedic implants, which are normally inert materials, are essential for their performance in vivo. This review summarizes recent advances in the surface modification of orthopaedic implants using facile and highly versatile techniques based on the use of polydopamine (PDA) and its derivatives. Keywords: Implants, Orthopaedic, Polydopamine, Surface modification |
| first_indexed | 2024-04-12T11:06:23Z |
| format | Article |
| id | doaj.art-1829b8943c114fcf893e283fe09c102a |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-04-12T11:06:23Z |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-1829b8943c114fcf893e283fe09c102a2022-12-22T03:35:45ZengElsevierJournal of Orthopaedic Translation2214-031X2019-04-01178295Polydopamine-assisted surface modification for orthopaedic implantsLuanluan Jia0Fengxuan Han1Huan Wang2Caihong Zhu3Qianping Guo4Jiaying Li5Zhongliang Zhao6Qiang Zhang7Xuesong Zhu8Bin Li9Department of Orthopaedic Surgery, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China; College of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China; College of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, ChinaCollege of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, Jiangsu, ChinaCollege of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, Jiangsu, ChinaCollege of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, Jiangsu, ChinaCollege of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, Jiangsu, ChinaSecond Orthopedics Department, Pingxiang Traditional Chinese Medicine Hospital, Pingxiang, Jiangxi, ChinaDepartment of Orthopaedic Surgery, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China; Corresponding author.Department of Orthopaedic Surgery, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China; College of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, Jiangsu, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, Zhejiang, China; Corresponding author. 708 Renmin Rd, Rm 308 Bldg 1, Soochow University (South Campus), Suzhou, Jiangsu 215007, China.Along with the massive use of implants in orthopaedic surgeries in recent few decades, there has been a tremendous demand for the surface modification of the implants to avoid surgery failure and improve their function. Polydopamine (PDA), being able to adhere to almost all kinds of substrates and possessing copious functional groups for covalently immobilizing biomolecules and anchoring metal ions, has been widely used for surface modification of materials since its discovery in the last decade. PDA and its derivatives can be used for the surface modification of orthopaedic implants to modulate cellular responses, including cell spreading, migration, proliferation, and differentiation, and may thereby enhance the function of existing implants. In addition, the osseointegration and antimicrobial properties of orthopaedic implants may also be improved by PDA-based coatings. The aim of this review is to provide a brief overview of current advances of surface modification technologies for orthopaedic implants using PDA and its derivatives as a medium. Given the versatility of PDA-based adhesion, such PDA-assisted surface modification technologies will certainly benefit the development of new orthopaedic implants. The translational potential of this article: Surface treatments of orthopaedic implants, which are normally inert materials, are essential for their performance in vivo. This review summarizes recent advances in the surface modification of orthopaedic implants using facile and highly versatile techniques based on the use of polydopamine (PDA) and its derivatives. Keywords: Implants, Orthopaedic, Polydopamine, Surface modificationhttp://www.sciencedirect.com/science/article/pii/S2214031X19300439 |
| spellingShingle | Luanluan Jia Fengxuan Han Huan Wang Caihong Zhu Qianping Guo Jiaying Li Zhongliang Zhao Qiang Zhang Xuesong Zhu Bin Li Polydopamine-assisted surface modification for orthopaedic implants Journal of Orthopaedic Translation |
| title | Polydopamine-assisted surface modification for orthopaedic implants |
| title_full | Polydopamine-assisted surface modification for orthopaedic implants |
| title_fullStr | Polydopamine-assisted surface modification for orthopaedic implants |
| title_full_unstemmed | Polydopamine-assisted surface modification for orthopaedic implants |
| title_short | Polydopamine-assisted surface modification for orthopaedic implants |
| title_sort | polydopamine assisted surface modification for orthopaedic implants |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X19300439 |
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