Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass Grafting
Liang Chen, Xiao-Hang Ding, Kang-Jun Fan, Ming-Xin Gao, Wen-Yuan Yu, Hong-Li Liu, Yang Yu Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People’s Republic of ChinaCorrespondence: Yang Yu, Email heartyuyang@hotmail.comBackground: Data on the relat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-between-triglyceride-glucose-index-and-2-year-adverse-card-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1811173705576873984 |
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| author | Chen L Ding XH Fan KJ Gao MX Yu WY Liu HL Yu Y |
| author_facet | Chen L Ding XH Fan KJ Gao MX Yu WY Liu HL Yu Y |
| author_sort | Chen L |
| collection | DOAJ |
| description | Liang Chen, Xiao-Hang Ding, Kang-Jun Fan, Ming-Xin Gao, Wen-Yuan Yu, Hong-Li Liu, Yang Yu Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People’s Republic of ChinaCorrespondence: Yang Yu, Email heartyuyang@hotmail.comBackground: Data on the relationship between the triglyceride glucose (TyG) index and prognosis after off-pump coronary artery bypass grafting (OPCABG) are limited. This retrospective observational cohort study evaluated the association of the TyG index with prognosis in patients with diabetes mellitus who underwent OPCABG.Methods: The TyG index was calculated using the following equation: TyG index = ln (fasting triglyceride level [mg/dL] × fasting glucose level [mg/dL]/2). The primary outcomes included the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs), which were defined as all-cause death, nonfatal myocardial infarction, nonfatal stroke and symptomatic graft failure. The association between the TyG index and MACCEs was assessed by Cox proportional hazards regression analysis.Results: A total of 1578 patients with diabetes who underwent OPCABG (mean age, 62.9 ± 8.0 years; men, 72.7%) were enrolled in this study. Over the follow-up of 2 years, 176 patients (11.2%) had at least 1 primary endpoint event. The follow-up incidence of the primary endpoint rose with increasing TyG index tertiles. The multivariate Cox proportional hazards regression analysis adjusted for multiple confounders revealed a hazard ratio for the primary endpoint of 2.133 (95% CI 1.347– 3.377; P for trend = 0.001) when the highest and lowest TyG index tertiles were compared.Conclusion: The TyG index was significantly and positively associated with MACCEs, suggesting that the TyG index may be a valuable predictor of adverse cardiovascular and cerebrovascular outcomes after OPCABG in patients with T2DM.Keywords: triglyceride-glucose index, off-pump coronary artery bypass grafting, major adverse cardiovascular and cerebrovascular events, type 2 diabetes mellitus |
| first_indexed | 2024-04-10T17:51:32Z |
| format | Article |
| id | doaj.art-182a8ff2a27744e9927136d4793fccd6 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T17:51:32Z |
| publishDate | 2022-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-182a8ff2a27744e9927136d4793fccd62023-02-02T20:40:30ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-02-01Volume 1543945072953Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass GraftingChen LDing XHFan KJGao MXYu WYLiu HLYu YLiang Chen, Xiao-Hang Ding, Kang-Jun Fan, Ming-Xin Gao, Wen-Yuan Yu, Hong-Li Liu, Yang Yu Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People’s Republic of ChinaCorrespondence: Yang Yu, Email heartyuyang@hotmail.comBackground: Data on the relationship between the triglyceride glucose (TyG) index and prognosis after off-pump coronary artery bypass grafting (OPCABG) are limited. This retrospective observational cohort study evaluated the association of the TyG index with prognosis in patients with diabetes mellitus who underwent OPCABG.Methods: The TyG index was calculated using the following equation: TyG index = ln (fasting triglyceride level [mg/dL] × fasting glucose level [mg/dL]/2). The primary outcomes included the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs), which were defined as all-cause death, nonfatal myocardial infarction, nonfatal stroke and symptomatic graft failure. The association between the TyG index and MACCEs was assessed by Cox proportional hazards regression analysis.Results: A total of 1578 patients with diabetes who underwent OPCABG (mean age, 62.9 ± 8.0 years; men, 72.7%) were enrolled in this study. Over the follow-up of 2 years, 176 patients (11.2%) had at least 1 primary endpoint event. The follow-up incidence of the primary endpoint rose with increasing TyG index tertiles. The multivariate Cox proportional hazards regression analysis adjusted for multiple confounders revealed a hazard ratio for the primary endpoint of 2.133 (95% CI 1.347– 3.377; P for trend = 0.001) when the highest and lowest TyG index tertiles were compared.Conclusion: The TyG index was significantly and positively associated with MACCEs, suggesting that the TyG index may be a valuable predictor of adverse cardiovascular and cerebrovascular outcomes after OPCABG in patients with T2DM.Keywords: triglyceride-glucose index, off-pump coronary artery bypass grafting, major adverse cardiovascular and cerebrovascular events, type 2 diabetes mellitushttps://www.dovepress.com/association-between-triglyceride-glucose-index-and-2-year-adverse-card-peer-reviewed-fulltext-article-DMSOtriglyceride-glucose indexoff-pump coronary artery bypass graftingmajor adverse cardiovascular and cerebrovascular eventstype 2 diabetes mellitus |
| spellingShingle | Chen L Ding XH Fan KJ Gao MX Yu WY Liu HL Yu Y Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass Grafting Diabetes, Metabolic Syndrome and Obesity triglyceride-glucose index off-pump coronary artery bypass grafting major adverse cardiovascular and cerebrovascular events type 2 diabetes mellitus |
| title | Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass Grafting |
| title_full | Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass Grafting |
| title_fullStr | Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass Grafting |
| title_full_unstemmed | Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass Grafting |
| title_short | Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass Grafting |
| title_sort | association between triglyceride glucose index and 2 year adverse cardiovascular and cerebrovascular events in patients with type 2 diabetes mellitus who underwent off pump coronary artery bypass grafting |
| topic | triglyceride-glucose index off-pump coronary artery bypass grafting major adverse cardiovascular and cerebrovascular events type 2 diabetes mellitus |
| url | https://www.dovepress.com/association-between-triglyceride-glucose-index-and-2-year-adverse-card-peer-reviewed-fulltext-article-DMSO |
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