Disconnection in a left-hemispheric temporo-parietal network impairs multiplication fact retrieval
Arithmetic fact retrieval has been suggested to recruit a left-lateralized network comprising perisylvian language areas, parietal areas such as the angular gyrus (AG), and non-neocortical structures such as the hippocampus. However, the underlying white matter connectivity of these areas has not be...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922009612 |
| _version_ | 1811169469113827328 |
|---|---|
| author | S. Smaczny C. Sperber S. Jung K. Moeller H.O. Karnath E. Klein |
| author_facet | S. Smaczny C. Sperber S. Jung K. Moeller H.O. Karnath E. Klein |
| author_sort | S. Smaczny |
| collection | DOAJ |
| description | Arithmetic fact retrieval has been suggested to recruit a left-lateralized network comprising perisylvian language areas, parietal areas such as the angular gyrus (AG), and non-neocortical structures such as the hippocampus. However, the underlying white matter connectivity of these areas has not been evaluated systematically so far. Using simple multiplication problems, we evaluated how disconnections in parietal brain areas affected arithmetic fact retrieval following stroke. We derived disconnectivity measures by jointly considering data from n = 73 patients with acute unilateral lesions in either hemisphere and a white-matter tractography atlas (HCP-842) using the Lesion Quantification Toolbox (LQT). Whole-brain voxel-based analysis indicated a left-hemispheric cluster of white matter fibers connecting the AG and superior temporal areas to be associated with a fact retrieval deficit. Subsequent analyses of direct gray-to-gray matter disconnections revealed that disconnections of additional left-hemispheric areas (e.g., between the superior temporal gyrus and parietal areas) were significantly associated with the observed fact retrieval deficit. Results imply that disconnections of parietal areas (i.e., the AG) with language-related areas (i.e., superior and middle temporal gyri) seem specifically detrimental to arithmetic fact retrieval. This suggests that arithmetic fact retrieval recruits a widespread left-hemispheric network and emphasizes the relevance of white matter connectivity for number processing. |
| first_indexed | 2024-04-10T16:42:55Z |
| format | Article |
| id | doaj.art-182b3bfef3ab4238a6e5365f78fbf738 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-10T16:42:55Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-182b3bfef3ab4238a6e5365f78fbf7382023-02-08T04:16:26ZengElsevierNeuroImage1095-95722023-03-01268119840Disconnection in a left-hemispheric temporo-parietal network impairs multiplication fact retrievalS. Smaczny0C. Sperber1S. Jung2K. Moeller3H.O. Karnath4E. Klein5Centre of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, GermanyDepartment of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, SwitzerlandDepartment of Computer Science/Therapy Science, Trier University of Applied Science, Trier, Germany; Leibniz Institut fuer Wissensmedien, Tuebingen, GermanyLeibniz Institut fuer Wissensmedien, Tuebingen, Germany; Centre for Individual Development and Adaptive Education of Children at Risk (IDeA), Frankfurt, Germany; Centre for Mathematical Cognition, School of Science, Loughborough University, United KingdomCentre of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany; Department of Psychology, University of South Carolina, Columbia, SC, USA; Corresponding author.Leibniz Institut fuer Wissensmedien, Tuebingen, Germany; University of Paris, LaPsyDÉ, CNRS, Sorbonne Paris Cité, Paris, France; Corresponding author.Arithmetic fact retrieval has been suggested to recruit a left-lateralized network comprising perisylvian language areas, parietal areas such as the angular gyrus (AG), and non-neocortical structures such as the hippocampus. However, the underlying white matter connectivity of these areas has not been evaluated systematically so far. Using simple multiplication problems, we evaluated how disconnections in parietal brain areas affected arithmetic fact retrieval following stroke. We derived disconnectivity measures by jointly considering data from n = 73 patients with acute unilateral lesions in either hemisphere and a white-matter tractography atlas (HCP-842) using the Lesion Quantification Toolbox (LQT). Whole-brain voxel-based analysis indicated a left-hemispheric cluster of white matter fibers connecting the AG and superior temporal areas to be associated with a fact retrieval deficit. Subsequent analyses of direct gray-to-gray matter disconnections revealed that disconnections of additional left-hemispheric areas (e.g., between the superior temporal gyrus and parietal areas) were significantly associated with the observed fact retrieval deficit. Results imply that disconnections of parietal areas (i.e., the AG) with language-related areas (i.e., superior and middle temporal gyri) seem specifically detrimental to arithmetic fact retrieval. This suggests that arithmetic fact retrieval recruits a widespread left-hemispheric network and emphasizes the relevance of white matter connectivity for number processing.http://www.sciencedirect.com/science/article/pii/S1053811922009612DisconnectomeVLSMArithmetic fact retrievalLesion mappingConnectivity |
| spellingShingle | S. Smaczny C. Sperber S. Jung K. Moeller H.O. Karnath E. Klein Disconnection in a left-hemispheric temporo-parietal network impairs multiplication fact retrieval NeuroImage Disconnectome VLSM Arithmetic fact retrieval Lesion mapping Connectivity |
| title | Disconnection in a left-hemispheric temporo-parietal network impairs multiplication fact retrieval |
| title_full | Disconnection in a left-hemispheric temporo-parietal network impairs multiplication fact retrieval |
| title_fullStr | Disconnection in a left-hemispheric temporo-parietal network impairs multiplication fact retrieval |
| title_full_unstemmed | Disconnection in a left-hemispheric temporo-parietal network impairs multiplication fact retrieval |
| title_short | Disconnection in a left-hemispheric temporo-parietal network impairs multiplication fact retrieval |
| title_sort | disconnection in a left hemispheric temporo parietal network impairs multiplication fact retrieval |
| topic | Disconnectome VLSM Arithmetic fact retrieval Lesion mapping Connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922009612 |
| work_keys_str_mv | AT ssmaczny disconnectioninalefthemispherictemporoparietalnetworkimpairsmultiplicationfactretrieval AT csperber disconnectioninalefthemispherictemporoparietalnetworkimpairsmultiplicationfactretrieval AT sjung disconnectioninalefthemispherictemporoparietalnetworkimpairsmultiplicationfactretrieval AT kmoeller disconnectioninalefthemispherictemporoparietalnetworkimpairsmultiplicationfactretrieval AT hokarnath disconnectioninalefthemispherictemporoparietalnetworkimpairsmultiplicationfactretrieval AT eklein disconnectioninalefthemispherictemporoparietalnetworkimpairsmultiplicationfactretrieval |