Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration
The treatment of infected bone defects is an intractable problem in orthopedics. It comprises two critical parts, namely that of infection control and bone defect repair. According to these two core tasks during treatment, the ideal approach of simultaneously controlling infection and repairing bone...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422002071 |
| _version_ | 1797990835056279552 |
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| author | Yutao Cui He Liu Yuhang Tian Yi Fan Shaorong Li Gan Wang Yanbing Wang Chuangang Peng Dankai Wu |
| author_facet | Yutao Cui He Liu Yuhang Tian Yi Fan Shaorong Li Gan Wang Yanbing Wang Chuangang Peng Dankai Wu |
| author_sort | Yutao Cui |
| collection | DOAJ |
| description | The treatment of infected bone defects is an intractable problem in orthopedics. It comprises two critical parts, namely that of infection control and bone defect repair. According to these two core tasks during treatment, the ideal approach of simultaneously controlling infection and repairing bone defects is promising treatment strategy. Several engineered biomaterials and drug delivery systems with dual functions of anti-bacterial action and ostogenesis-promotion have been developed and demonstrated excellent therapeutic effects. Compared with the conventional treatment method, the dual-functional composite scaffold can provide one-stage treatment avoiding multiple surgeries, thereby remarkably simplifying the treatment process and reducing the treatment time, overcoming the disadvantages of conventional bone transplantation. In this review, the impaired bone repair ability and its specific mechanisms in the microenvironment of pathogen infection and excessive inflammation were analyzed, providing a theoretical basis for the treatment of infectious bone defects. Furthermore, we discussed the composite dual-functional scaffold composed of a combination of antibacterial and osteogenic material. Finally, a series of advanced drug delivery systems with antibacterial and bone-promoting capabilities were summarized and discussed. This review provides a comprehensive understanding for the microenvironment of infectious bone defects and leading-edge design strategies for the antibacterial and bone-promoting dual-function scaffold, thus providing clinically significant treatment methods for infectious bone defects. |
| first_indexed | 2024-04-11T08:41:42Z |
| format | Article |
| id | doaj.art-182ba8a1061443548f7a919f4c26309a |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-11T08:41:42Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-182ba8a1061443548f7a919f4c26309a2022-12-22T04:34:08ZengElsevierMaterials Today Bio2590-00642022-12-0116100409Dual-functional composite scaffolds for inhibiting infection and promoting bone regenerationYutao Cui0He Liu1Yuhang Tian2Yi Fan3Shaorong Li4Gan Wang5Yanbing Wang6Chuangang Peng7Dankai Wu8Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaCorresponding author.; Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaThe treatment of infected bone defects is an intractable problem in orthopedics. It comprises two critical parts, namely that of infection control and bone defect repair. According to these two core tasks during treatment, the ideal approach of simultaneously controlling infection and repairing bone defects is promising treatment strategy. Several engineered biomaterials and drug delivery systems with dual functions of anti-bacterial action and ostogenesis-promotion have been developed and demonstrated excellent therapeutic effects. Compared with the conventional treatment method, the dual-functional composite scaffold can provide one-stage treatment avoiding multiple surgeries, thereby remarkably simplifying the treatment process and reducing the treatment time, overcoming the disadvantages of conventional bone transplantation. In this review, the impaired bone repair ability and its specific mechanisms in the microenvironment of pathogen infection and excessive inflammation were analyzed, providing a theoretical basis for the treatment of infectious bone defects. Furthermore, we discussed the composite dual-functional scaffold composed of a combination of antibacterial and osteogenic material. Finally, a series of advanced drug delivery systems with antibacterial and bone-promoting capabilities were summarized and discussed. This review provides a comprehensive understanding for the microenvironment of infectious bone defects and leading-edge design strategies for the antibacterial and bone-promoting dual-function scaffold, thus providing clinically significant treatment methods for infectious bone defects.http://www.sciencedirect.com/science/article/pii/S2590006422002071AntibacterialBone repairInfectious bone defectDual-functional scaffold |
| spellingShingle | Yutao Cui He Liu Yuhang Tian Yi Fan Shaorong Li Gan Wang Yanbing Wang Chuangang Peng Dankai Wu Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration Materials Today Bio Antibacterial Bone repair Infectious bone defect Dual-functional scaffold |
| title | Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration |
| title_full | Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration |
| title_fullStr | Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration |
| title_full_unstemmed | Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration |
| title_short | Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration |
| title_sort | dual functional composite scaffolds for inhibiting infection and promoting bone regeneration |
| topic | Antibacterial Bone repair Infectious bone defect Dual-functional scaffold |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422002071 |
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