Genetic bases of arrhythmogenic right ventricular cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease in which the pathological substrate is a fibro-fatty replacement of the right ventricular myocardium. The major clinical features are different types of arrhythmias with a left branch block pattern. ARVC shows autosomal...
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| Format: | Article |
| Language: | English |
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Touch Medical Media
2010-05-01
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| Series: | Heart International |
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| Online Access: | http://www.pagepress.org/journals/index.php/hi/article/view/1877 |
| _version_ | 1819092020217511936 |
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| author | Alessandra Rampazzo |
| author_facet | Alessandra Rampazzo |
| author_sort | Alessandra Rampazzo |
| collection | DOAJ |
| description | Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease in which the pathological substrate is a fibro-fatty replacement of the right ventricular myocardium. The major clinical features are different types of arrhythmias with a left branch block pattern. ARVC shows autosomal dominant inheritance with incomplete penetrance. Recessive forms were also described, although in association with skin disorders. Ten genetic loci have been discovered so far and mutations were reported in five different genes. ARVD1 was associated with regulatory mutations of transforming growth factor beta-3 (TGFβ3), whereas ARVD2, characterized by effort-induced polymorphic arrhythmias, was associated with mutations in cardiac ryanodine receptor-2 (RYR2). All other mutations identified to date have been detected in genes encoding desmosomal proteins: plakoglobin (JUP) which causes Naxos disease (a recessive form of ARVC associated with palmoplantar keratosis and woolly hair); desmoplakin (DSP) which causes the autosomal dominant ARVD8 and plakophilin-2 (PKP2) involved in ARVD9. Desmosomes are important cell-to-cell adhesion junctions predominantly found in epidermis and heart; they are believed to couple cytoskeletal elements to plasma membrane in cell-to-cell or cell-to-substrate adhesions. |
| first_indexed | 2024-12-21T22:48:58Z |
| format | Article |
| id | doaj.art-182c426466534077b085cd3e2b728102 |
| institution | Directory Open Access Journal |
| issn | 1826-1868 2036-2579 |
| language | English |
| last_indexed | 2024-12-21T22:48:58Z |
| publishDate | 2010-05-01 |
| publisher | Touch Medical Media |
| record_format | Article |
| series | Heart International |
| spelling | doaj.art-182c426466534077b085cd3e2b7281022022-12-21T18:47:37ZengTouch Medical MediaHeart International1826-18682036-25792010-05-0121172610.4081/hi.2006.17Genetic bases of arrhythmogenic right ventricular cardiomyopathyAlessandra RampazzoArrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease in which the pathological substrate is a fibro-fatty replacement of the right ventricular myocardium. The major clinical features are different types of arrhythmias with a left branch block pattern. ARVC shows autosomal dominant inheritance with incomplete penetrance. Recessive forms were also described, although in association with skin disorders. Ten genetic loci have been discovered so far and mutations were reported in five different genes. ARVD1 was associated with regulatory mutations of transforming growth factor beta-3 (TGFβ3), whereas ARVD2, characterized by effort-induced polymorphic arrhythmias, was associated with mutations in cardiac ryanodine receptor-2 (RYR2). All other mutations identified to date have been detected in genes encoding desmosomal proteins: plakoglobin (JUP) which causes Naxos disease (a recessive form of ARVC associated with palmoplantar keratosis and woolly hair); desmoplakin (DSP) which causes the autosomal dominant ARVD8 and plakophilin-2 (PKP2) involved in ARVD9. Desmosomes are important cell-to-cell adhesion junctions predominantly found in epidermis and heart; they are believed to couple cytoskeletal elements to plasma membrane in cell-to-cell or cell-to-substrate adhesions.http://www.pagepress.org/journals/index.php/hi/article/view/1877Arrhythmias, Sudden death, Molecular genetics, Desmosomes |
| spellingShingle | Alessandra Rampazzo Genetic bases of arrhythmogenic right ventricular cardiomyopathy Heart International Arrhythmias, Sudden death, Molecular genetics, Desmosomes |
| title | Genetic bases of arrhythmogenic right ventricular cardiomyopathy |
| title_full | Genetic bases of arrhythmogenic right ventricular cardiomyopathy |
| title_fullStr | Genetic bases of arrhythmogenic right ventricular cardiomyopathy |
| title_full_unstemmed | Genetic bases of arrhythmogenic right ventricular cardiomyopathy |
| title_short | Genetic bases of arrhythmogenic right ventricular cardiomyopathy |
| title_sort | genetic bases of arrhythmogenic right ventricular cardiomyopathy |
| topic | Arrhythmias, Sudden death, Molecular genetics, Desmosomes |
| url | http://www.pagepress.org/journals/index.php/hi/article/view/1877 |
| work_keys_str_mv | AT alessandrarampazzo geneticbasesofarrhythmogenicrightventricularcardiomyopathy |