Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study
Hua Xiao,1,2 Xiaofei Shao,3 Peichun Gao,4 Hequn Zou,5 Xinzhou Zhang1 1Department of Nephrology, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, 518020, People’s Republic of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-03-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/metabolic-syndrome-components-and-chronic-kidney-disease-in-a-communit-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1827843711994691584 |
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| author | Xiao H Shao X Gao P Zou H Zhang X |
| author_facet | Xiao H Shao X Gao P Zou H Zhang X |
| author_sort | Xiao H |
| collection | DOAJ |
| description | Hua Xiao,1,2 Xiaofei Shao,3 Peichun Gao,4 Hequn Zou,5 Xinzhou Zhang1 1Department of Nephrology, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, 518020, People’s Republic of China; 2Shenzhen Key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, 518055, People’s Republic of China; 3Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, People’s Republic of China; 4Zhujiang Hospital of Southern Medical University, Guangzhou, 510282, People’s Republic of China; 5Department of Nephrology, South China Hospital, Health Science Center, Shenzhen University, Shenzhen, 518116, People’s Republic of ChinaCorrespondence: Xinzhou Zhang, Department of Nephrology, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, 518020, People’s Republic of China, Tel +86 0755-25533018-3500, Fax +86 0755-25533497, Email xin.zhou2@qq.com Hequn Zou, Department of Nephrology, South China Hospital, Health Science Center, Shenzhen University, Shenzhen, 518116, People’s Republic of China, Tel +860755-21583803, Email hequnzou@hotmail.comPurpose: To investigate the correlation between metabolic syndrome components and chronic kidney disease (CKD) among a community population aged 40 years and older in Southern China.Patients and Methods: From December 2017 to March 2018, 1969 participants (male n = 715, female n = 1254) aged 40 years and older were recruited in Southern China for a cross-sectional survey. A logistic regression model was established to analyze the correlation between metabolic syndrome components and CKD.Results: Among the 1969 subjects, 407 (20.7%) were CKD patients, including 152 males (prevalence rate 21.3%) and 255 females (prevalence rate 20.3%). Anthropometric data (waist circumference, age, systolic and diastolic blood pressure), serum/plasma data (serum creatinine, serum uric acid, fasting plasma glucose, C-reactive protein, serum triglyceride), urinary and other findings (body mass index, waist-to-hip and waist-to-height ratios, urinary albumin to creatinine ratio, homeostasis model assessment of insulin resistance) were significantly higher in patients with than without CKD (P < 0.05). Metabolic syndrome and at least some of its components were statistically significant risk factors for CKD in models with and without adjustment for diabetes, obesity and hypertension.Conclusion: Metabolic syndrome and its single or combined components are independently associated with CKD in community populations aged 40 years and older. The correlation between some components and CKD remained significant in both non-diabetic and non-obese subjects. Correlations between components of metabolic syndrome and CKD show that it is feasible and necessary to carry out targeted screening and intervention tests in people aged 40 and over.Keywords: metabolic syndrome, chronic kidney disease, risk factors, epidemiological cross-sectional study |
| first_indexed | 2024-03-12T08:30:27Z |
| format | Article |
| id | doaj.art-182c60b89abe48e6bd53c272629c487d |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-12T08:30:27Z |
| publishDate | 2022-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-182c60b89abe48e6bd53c272629c487d2023-09-02T17:42:07ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-03-01Volume 1583984873749Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional StudyXiao HShao XGao PZou HZhang XHua Xiao,1,2 Xiaofei Shao,3 Peichun Gao,4 Hequn Zou,5 Xinzhou Zhang1 1Department of Nephrology, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, 518020, People’s Republic of China; 2Shenzhen Key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, 518055, People’s Republic of China; 3Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, People’s Republic of China; 4Zhujiang Hospital of Southern Medical University, Guangzhou, 510282, People’s Republic of China; 5Department of Nephrology, South China Hospital, Health Science Center, Shenzhen University, Shenzhen, 518116, People’s Republic of ChinaCorrespondence: Xinzhou Zhang, Department of Nephrology, Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, 518020, People’s Republic of China, Tel +86 0755-25533018-3500, Fax +86 0755-25533497, Email xin.zhou2@qq.com Hequn Zou, Department of Nephrology, South China Hospital, Health Science Center, Shenzhen University, Shenzhen, 518116, People’s Republic of China, Tel +860755-21583803, Email hequnzou@hotmail.comPurpose: To investigate the correlation between metabolic syndrome components and chronic kidney disease (CKD) among a community population aged 40 years and older in Southern China.Patients and Methods: From December 2017 to March 2018, 1969 participants (male n = 715, female n = 1254) aged 40 years and older were recruited in Southern China for a cross-sectional survey. A logistic regression model was established to analyze the correlation between metabolic syndrome components and CKD.Results: Among the 1969 subjects, 407 (20.7%) were CKD patients, including 152 males (prevalence rate 21.3%) and 255 females (prevalence rate 20.3%). Anthropometric data (waist circumference, age, systolic and diastolic blood pressure), serum/plasma data (serum creatinine, serum uric acid, fasting plasma glucose, C-reactive protein, serum triglyceride), urinary and other findings (body mass index, waist-to-hip and waist-to-height ratios, urinary albumin to creatinine ratio, homeostasis model assessment of insulin resistance) were significantly higher in patients with than without CKD (P < 0.05). Metabolic syndrome and at least some of its components were statistically significant risk factors for CKD in models with and without adjustment for diabetes, obesity and hypertension.Conclusion: Metabolic syndrome and its single or combined components are independently associated with CKD in community populations aged 40 years and older. The correlation between some components and CKD remained significant in both non-diabetic and non-obese subjects. Correlations between components of metabolic syndrome and CKD show that it is feasible and necessary to carry out targeted screening and intervention tests in people aged 40 and over.Keywords: metabolic syndrome, chronic kidney disease, risk factors, epidemiological cross-sectional studyhttps://www.dovepress.com/metabolic-syndrome-components-and-chronic-kidney-disease-in-a-communit-peer-reviewed-fulltext-article-DMSOmetabolic syndromechronic kidney diseaserisk factorsepidemiological cross-sectional study. |
| spellingShingle | Xiao H Shao X Gao P Zou H Zhang X Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study Diabetes, Metabolic Syndrome and Obesity metabolic syndrome chronic kidney disease risk factors epidemiological cross-sectional study. |
| title | Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study |
| title_full | Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study |
| title_fullStr | Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study |
| title_full_unstemmed | Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study |
| title_short | Metabolic Syndrome Components and Chronic Kidney Disease in a Community Population Aged 40 Years and Older in Southern China: A Cross-Sectional Study |
| title_sort | metabolic syndrome components and chronic kidney disease in a community population aged 40 years and older in southern china a cross sectional study |
| topic | metabolic syndrome chronic kidney disease risk factors epidemiological cross-sectional study. |
| url | https://www.dovepress.com/metabolic-syndrome-components-and-chronic-kidney-disease-in-a-communit-peer-reviewed-fulltext-article-DMSO |
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