Efficacy of Novel Carbon Nanoparticle Antioxidant Therapy in a Severe Model of Reversible Middle Cerebral Artery Stroke in Acutely Hyperglycemic Rats

Efficacy of Novel Carbon Nanoparticle Antioxidant Therapy in a Severe Model of Reversible Middle Cerebral Artery Stroke in Acutely Hyperglycemic Rats

IntroductionWhile oxidative stress can be measured during transient cerebral ischemia, antioxidant therapies for ischemic stroke have been clinically unsuccessful. Many antioxidants are limited in their range and/or capacity for quenching radicals and can generate toxic intermediates overwhelming de...

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Bibliographic Details
Main Authors: Roderic H. Fabian, Paul J. Derry, Harriett Charmaine Rea, William V. Dalmeida, Lizanne G. Nilewski, William K. A. Sikkema, Pitchaiah Mandava, Ah-Lim Tsai, Kimberly Mendoza, Vladimir Berka, James M. Tour, Thomas A. Kent
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Neurology
Subjects:
diabetes mellitus
stroke
rat model
hyperglycemia
antioxidants
nanomedicine
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00199/full

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