Long term trends of breast cancer incidence according to proliferation status
Abstract Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. Methods Among 83,298 Norwegian women followed for breast cancer occurrenc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-10438-1 |
| _version_ | 1797977385215197184 |
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| author | Elise Klæstad Signe Opdahl Sunil Xavier Raj Anna Mary Bofin Marit Valla |
| author_facet | Elise Klæstad Signe Opdahl Sunil Xavier Raj Anna Mary Bofin Marit Valla |
| author_sort | Elise Klæstad |
| collection | DOAJ |
| description | Abstract Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. Methods Among 83,298 Norwegian women followed for breast cancer occurrence 1961–2012, 2995 incident breast cancers were diagnosed. Ki-67 was assessed using immunohistochemistry on tissue microarrays and mitoses were counted on whole sections. We compared incidence rates according to proliferation status among women born 1886–1928 and 1929–1977, estimating age-specific incidence rate ratios. We performed multiple imputations to account for unknown proliferation status. Mean values of Ki-67 and mitotic counts were calculated, according to age and birth year. We performed separate incidence analyses for HER2+ and triple negative breast cancers. Results Among women aged 40–69 years, incidence rates of tumours with low-proliferative activity were higher among those born in 1929 or later, compared to before 1929, according to Ki-67 and mitotic count. Incidence rates of tumours with high-proliferative activity were also higher in women born in 1929 or later compared to before 1929 according to Ki-67, but not according to mitotic count. Mean values of Ki-67 and mitotic count varied according to age and birth year. In subtype-specific analyses we found an increase of high-proliferative HER2+ tumours according to Ki-67 in women born in 1929 or later, compared to before 1929. Conclusions There has been a temporal increase in both low- and high-proliferative breast cancers. |
| first_indexed | 2024-04-11T05:06:03Z |
| format | Article |
| id | doaj.art-182e78d9a4a9416eb8c787bf2e7fd39f |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-11T05:06:03Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-182e78d9a4a9416eb8c787bf2e7fd39f2022-12-25T12:19:26ZengBMCBMC Cancer1471-24072022-12-0122111210.1186/s12885-022-10438-1Long term trends of breast cancer incidence according to proliferation statusElise Klæstad0Signe Opdahl1Sunil Xavier Raj2Anna Mary Bofin3Marit Valla4Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyCancer Clinic, St. Olav’s Hospital, Trondheim University HospitalDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and TechnologyAbstract Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. Methods Among 83,298 Norwegian women followed for breast cancer occurrence 1961–2012, 2995 incident breast cancers were diagnosed. Ki-67 was assessed using immunohistochemistry on tissue microarrays and mitoses were counted on whole sections. We compared incidence rates according to proliferation status among women born 1886–1928 and 1929–1977, estimating age-specific incidence rate ratios. We performed multiple imputations to account for unknown proliferation status. Mean values of Ki-67 and mitotic counts were calculated, according to age and birth year. We performed separate incidence analyses for HER2+ and triple negative breast cancers. Results Among women aged 40–69 years, incidence rates of tumours with low-proliferative activity were higher among those born in 1929 or later, compared to before 1929, according to Ki-67 and mitotic count. Incidence rates of tumours with high-proliferative activity were also higher in women born in 1929 or later compared to before 1929 according to Ki-67, but not according to mitotic count. Mean values of Ki-67 and mitotic count varied according to age and birth year. In subtype-specific analyses we found an increase of high-proliferative HER2+ tumours according to Ki-67 in women born in 1929 or later, compared to before 1929. Conclusions There has been a temporal increase in both low- and high-proliferative breast cancers.https://doi.org/10.1186/s12885-022-10438-1Breast cancerIncidence trendsProliferationKi-67Mitotic count |
| spellingShingle | Elise Klæstad Signe Opdahl Sunil Xavier Raj Anna Mary Bofin Marit Valla Long term trends of breast cancer incidence according to proliferation status BMC Cancer Breast cancer Incidence trends Proliferation Ki-67 Mitotic count |
| title | Long term trends of breast cancer incidence according to proliferation status |
| title_full | Long term trends of breast cancer incidence according to proliferation status |
| title_fullStr | Long term trends of breast cancer incidence according to proliferation status |
| title_full_unstemmed | Long term trends of breast cancer incidence according to proliferation status |
| title_short | Long term trends of breast cancer incidence according to proliferation status |
| title_sort | long term trends of breast cancer incidence according to proliferation status |
| topic | Breast cancer Incidence trends Proliferation Ki-67 Mitotic count |
| url | https://doi.org/10.1186/s12885-022-10438-1 |
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