Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects
Protein acetylation modifications play a central and pivotal role in a myriad of biological processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and beyond, by effectively reshaping protein structure and function. The metabolic state of cells is intricately connected t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223013173 |
| _version_ | 1797660554837360640 |
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| author | Nan Jiang Wenyong Li Shuanglin Jiang Ming Xie Ran Liu |
| author_facet | Nan Jiang Wenyong Li Shuanglin Jiang Ming Xie Ran Liu |
| author_sort | Nan Jiang |
| collection | DOAJ |
| description | Protein acetylation modifications play a central and pivotal role in a myriad of biological processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and beyond, by effectively reshaping protein structure and function. The metabolic state of cells is intricately connected to epigenetic modifications, which in turn influence chromatin status and gene expression patterns. Notably, pathological alterations in protein acetylation modifications are frequently observed in diseases such as metabolic syndrome, cardiovascular disorders, and cancer. Such abnormalities can result in altered protein properties and loss of function, which are closely associated with developing and progressing related diseases. In recent years, the advancement of precision medicine has highlighted the potential value of protein acetylation in disease diagnosis, treatment, and prevention. This review includes provocative and thought-provoking papers outlining recent breakthroughs in acetylation modifications as they relate to cardiovascular disease, mitochondrial metabolic regulation, liver health, neurological health, obesity, diabetes, and cancer. Additionally, it covers the molecular mechanisms and research challenges in understanding the role of acetylation in disease regulation. By summarizing novel targets and prognostic markers for the treatment of related diseases, we aim to contribute to the field. Furthermore, we discuss current hot topics in acetylation research related to health regulation, including N4-acetylcytidine and liquid-liquid phase separation. The primary objective of this review is to provide insights into the functional diversity and underlying mechanisms by which acetylation regulates proteins in disease contexts. |
| first_indexed | 2024-03-11T18:31:35Z |
| format | Article |
| id | doaj.art-1835302dbed3445cbb4443a94597dd96 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T18:31:35Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-1835302dbed3445cbb4443a94597dd962023-10-13T11:02:56ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-11-01167115519Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospectsNan Jiang0Wenyong Li1Shuanglin Jiang2Ming Xie3Ran Liu4Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaSchool of Biology and Food Engineering, Fuyang Normal University, Fuyang, Anhui 236037, ChinaSchool of Biology and Food Engineering, Fuyang Normal University, Fuyang, Anhui 236037, ChinaNorth China Petroleum Bureau General Hospital, Renqiu 062550, China; Corresponding authors.Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Corresponding authors.Protein acetylation modifications play a central and pivotal role in a myriad of biological processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and beyond, by effectively reshaping protein structure and function. The metabolic state of cells is intricately connected to epigenetic modifications, which in turn influence chromatin status and gene expression patterns. Notably, pathological alterations in protein acetylation modifications are frequently observed in diseases such as metabolic syndrome, cardiovascular disorders, and cancer. Such abnormalities can result in altered protein properties and loss of function, which are closely associated with developing and progressing related diseases. In recent years, the advancement of precision medicine has highlighted the potential value of protein acetylation in disease diagnosis, treatment, and prevention. This review includes provocative and thought-provoking papers outlining recent breakthroughs in acetylation modifications as they relate to cardiovascular disease, mitochondrial metabolic regulation, liver health, neurological health, obesity, diabetes, and cancer. Additionally, it covers the molecular mechanisms and research challenges in understanding the role of acetylation in disease regulation. By summarizing novel targets and prognostic markers for the treatment of related diseases, we aim to contribute to the field. Furthermore, we discuss current hot topics in acetylation research related to health regulation, including N4-acetylcytidine and liquid-liquid phase separation. The primary objective of this review is to provide insights into the functional diversity and underlying mechanisms by which acetylation regulates proteins in disease contexts.http://www.sciencedirect.com/science/article/pii/S0753332223013173Protein acetylationEpigenetic modificationsPrecision medicineMolecular mechanismTherapeutic targets |
| spellingShingle | Nan Jiang Wenyong Li Shuanglin Jiang Ming Xie Ran Liu Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects Biomedicine & Pharmacotherapy Protein acetylation Epigenetic modifications Precision medicine Molecular mechanism Therapeutic targets |
| title | Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects |
| title_full | Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects |
| title_fullStr | Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects |
| title_full_unstemmed | Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects |
| title_short | Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects |
| title_sort | acetylation in pathogenesis revealing emerging mechanisms and therapeutic prospects |
| topic | Protein acetylation Epigenetic modifications Precision medicine Molecular mechanism Therapeutic targets |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223013173 |
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