Dynamic Cross-Correlation Matrix (DCCM) Reveals New Insights to Discover New NLRP3 Inhibitors Useful as Anti-Inflammatory Drugs

Dynamic Cross-Correlation Matrix (DCCM) Reveals New Insights to Discover New NLRP3 Inhibitors Useful as Anti-Inflammatory Drugs

The innate immune system is responsible for the body’s defense against aggressive agents, mainly through activating pattern-recognition receptors (PRRs). Recognizing these agents results in an inflammatory response that activates tissue repair and eliminates the agent. Among the macromolecules relat...

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Bibliographic Details
Main Authors: Igor José dos Santos Nascimento, Marianny De Souza, Daniel Calazans Medeiros, Ricardo Olimpio de Moura
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Medical Sciences Forum
Subjects:
NLRP3
DCCM
MD simulations
anti-inflammatory drugs
drug design
molecular modeling
Online Access:https://www.mdpi.com/2673-9992/14/1/84

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