Lactate Neuroprotection against Transient Ischemic Brain Injury in Mice Appears Independent of HCAR1 Activation

Lactate Neuroprotection against Transient Ischemic Brain Injury in Mice Appears Independent of HCAR1 Activation

Lactate can protect against damage caused by acute brain injuries both in rodents and in human patients. Besides its role as a metabolic support and alleged preferred neuronal fuel in stressful situations, an additional signaling mechanism mediated by the hydroxycarboxylic acid receptor 1 (HCAR1) wa...

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Bibliographic Details
Main Authors: Lara Buscemi, Melanie Price, Julia Castillo-González, Jean-Yves Chatton, Lorenz Hirt
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Metabolites
Subjects:
lactate
neuroprotection
MCAO
ischemia
stroke
HCAR1
Online Access:https://www.mdpi.com/2218-1989/12/5/465

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