Breast cancer immunology: theory and prospects (review)
This review deals with the detail presentation of the antitumor immunity basic mechanisms, of the interpretation of HLA class I and II histocompatibility genes - markers of the antigen-activated lymphocytes in the antigenic activation of lymphocytes and the role of T-cells (CD8+ T-killer cells and C...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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IP Habib O.N.
2015-03-01
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| Series: | Современная онкология |
| Subjects: | |
| Online Access: | https://modernonco.orscience.ru/1815-1434/article/view/26981 |
| _version_ | 1818308496890789888 |
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| author | I V Kolyadina I V Poddubnaya |
| author_facet | I V Kolyadina I V Poddubnaya |
| author_sort | I V Kolyadina |
| collection | DOAJ |
| description | This review deals with the detail presentation of the antitumor immunity basic mechanisms, of the interpretation of HLA class I and II histocompatibility genes - markers of the antigen-activated lymphocytes in the antigenic activation of lymphocytes and the role of T-cells (CD8+ T-killer cells and CD4+ T-helper cells) and NK cells in the realization of antitumor responses. We have described the unique mechanisms of cooperative humoral and cellular antitumor immunity - antibody-dependent cell-mediated cytotoxicity, and have evaluated its role in antitumor protecting the body against cancer. Advantages of the antitumor immunity is the possibility of T-lymphocytes to recognize tumor antigens in histocompatibility molecules of HLA-class I and II and-NK-cells to kill tumor cells without expression of HLA-class I and to acting in antibody-dependent cell-mediated cytotoxicity. The mutated cells can avoid the immune surveillance and cells cloning, the basis of these mechanisms is important immune processes; tumor progression can occur as a result of immune system damage (imperfect antitumor immunity) or as a result of tumor "immune invisibility". The causes of imperfect antitumor immunity are: the loss of tumor presentation histocompatibility molecules of HLA-class I and II, leading to the inability to show T-cell cytotoxicity, the expression of HLA-E and HLA-G, leading to blockade of NK-cells activity, the presence of suppressor Foxp3 + regulatory lymphocytes in tumor, the development of immunological tolerance (sustainable "unresponsiveness" of the immune system) during tumor growth and dissemination. We have showed the perspective study directions of prognostic and predicting roles of the immune tumor characteristics: subpopulations of stromal and intratumoral TILs, the markers expression HLA class I and II histocompatibility genes and non-classical suppressor molecu- les of HLA-E and HLA-G and tumor-infiltrating Foxp3(+)-lymphocytes. The study of the cellular and molecular basis of immune mechanisms will help us better understand the carcinogenesis and will optimize the therapeutic strategy for BC. |
| first_indexed | 2024-12-13T07:15:12Z |
| format | Article |
| id | doaj.art-1838133c76ba47868382650a9740a17b |
| institution | Directory Open Access Journal |
| issn | 1815-1434 1815-1442 |
| language | Russian |
| last_indexed | 2024-12-13T07:15:12Z |
| publishDate | 2015-03-01 |
| publisher | IP Habib O.N. |
| record_format | Article |
| series | Современная онкология |
| spelling | doaj.art-1838133c76ba47868382650a9740a17b2022-12-21T23:55:35ZrusIP Habib O.N.Современная онкология1815-14341815-14422015-03-01171121824201Breast cancer immunology: theory and prospects (review)I V Kolyadina0I V Poddubnaya1Russian Medical Academy for Postgraduate Education of the Ministry of Health of the Russian Federation; N.N.Blokhin Russian Cancer Research CenterRussian Medical Academy for Postgraduate Education of the Ministry of Health of the Russian Federation; N.N.Blokhin Russian Cancer Research CenterThis review deals with the detail presentation of the antitumor immunity basic mechanisms, of the interpretation of HLA class I and II histocompatibility genes - markers of the antigen-activated lymphocytes in the antigenic activation of lymphocytes and the role of T-cells (CD8+ T-killer cells and CD4+ T-helper cells) and NK cells in the realization of antitumor responses. We have described the unique mechanisms of cooperative humoral and cellular antitumor immunity - antibody-dependent cell-mediated cytotoxicity, and have evaluated its role in antitumor protecting the body against cancer. Advantages of the antitumor immunity is the possibility of T-lymphocytes to recognize tumor antigens in histocompatibility molecules of HLA-class I and II and-NK-cells to kill tumor cells without expression of HLA-class I and to acting in antibody-dependent cell-mediated cytotoxicity. The mutated cells can avoid the immune surveillance and cells cloning, the basis of these mechanisms is important immune processes; tumor progression can occur as a result of immune system damage (imperfect antitumor immunity) or as a result of tumor "immune invisibility". The causes of imperfect antitumor immunity are: the loss of tumor presentation histocompatibility molecules of HLA-class I and II, leading to the inability to show T-cell cytotoxicity, the expression of HLA-E and HLA-G, leading to blockade of NK-cells activity, the presence of suppressor Foxp3 + regulatory lymphocytes in tumor, the development of immunological tolerance (sustainable "unresponsiveness" of the immune system) during tumor growth and dissemination. We have showed the perspective study directions of prognostic and predicting roles of the immune tumor characteristics: subpopulations of stromal and intratumoral TILs, the markers expression HLA class I and II histocompatibility genes and non-classical suppressor molecu- les of HLA-E and HLA-G and tumor-infiltrating Foxp3(+)-lymphocytes. The study of the cellular and molecular basis of immune mechanisms will help us better understand the carcinogenesis and will optimize the therapeutic strategy for BC.https://modernonco.orscience.ru/1815-1434/article/view/26981breast cancer immunologyhla class i and ii histocompatibility genesthe expression of hla-e and hla-g cell markerstu- mor-infiltrating foxp3(+)-lymphocyteantibody-dependent cell-mediated cytotoxicityantitumor immunity |
| spellingShingle | I V Kolyadina I V Poddubnaya Breast cancer immunology: theory and prospects (review) Современная онкология breast cancer immunology hla class i and ii histocompatibility genes the expression of hla-e and hla-g cell markers tu- mor-infiltrating foxp3(+)-lymphocyte antibody-dependent cell-mediated cytotoxicity antitumor immunity |
| title | Breast cancer immunology: theory and prospects (review) |
| title_full | Breast cancer immunology: theory and prospects (review) |
| title_fullStr | Breast cancer immunology: theory and prospects (review) |
| title_full_unstemmed | Breast cancer immunology: theory and prospects (review) |
| title_short | Breast cancer immunology: theory and prospects (review) |
| title_sort | breast cancer immunology theory and prospects review |
| topic | breast cancer immunology hla class i and ii histocompatibility genes the expression of hla-e and hla-g cell markers tu- mor-infiltrating foxp3(+)-lymphocyte antibody-dependent cell-mediated cytotoxicity antitumor immunity |
| url | https://modernonco.orscience.ru/1815-1434/article/view/26981 |
| work_keys_str_mv | AT ivkolyadina breastcancerimmunologytheoryandprospectsreview AT ivpoddubnaya breastcancerimmunologytheoryandprospectsreview |