Induced by medication hepatotoxicity in an ambulatorial patient: case report
Background: Drug-induced hepatitis, also called toxic hepatitis or DILI (Drug Induced Liver Injury), accounts for about 2% of hospitalization cases of jaundice and liver damage is involved in 3-10% of all adverse drug reactions. Cases of hepatic injury associated with ibuprofen use are rare and the...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
2018-03-01
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| Series: | Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| Online Access: | https://rbfhss.org.br/sbrafh/article/view/309 |
| _version_ | 1819240793142984704 |
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| author | NÍLIA MARIA DE BRITO LIMA PRADO GLADISTONE CORREIA MESSIAS GENARIO OLIVEIRA SANTOS JUNIOR RAYMUNDO PARANÁ |
| author_facet | NÍLIA MARIA DE BRITO LIMA PRADO GLADISTONE CORREIA MESSIAS GENARIO OLIVEIRA SANTOS JUNIOR RAYMUNDO PARANÁ |
| author_sort | NÍLIA MARIA DE BRITO LIMA PRADO |
| collection | DOAJ |
| description | Background: Drug-induced hepatitis, also called toxic hepatitis or DILI (Drug Induced Liver Injury), accounts for about 2% of hospitalization cases of jaundice and liver damage is involved in 3-10% of all adverse drug reactions. Cases of hepatic injury associated with ibuprofen use are rare and the frequency of idiosyncratic hepatotoxicity is small. Objective: To report a case of hepatic injury induced by ibuprofen identified in a medium complexity outpatient clinic. Case report: A 48-year-old female patient was admitted to a Specialized Care Center in the southwestern state of Bahia for a consultation with an orthopedist complaining of low back pain, and ibuprofen and sodium dipyrone were prescribed to relieve symptoms. After 15 days of treatment, the patient returns to the service complaining of arthralgia in the upper limbs, right hand edema, jaundice, coluria, fecal suppura, asthenia and intense pruritus. From the investigation of the presented case, viral and autoimmune etiologies were ruled out. Ultrasonography of the total abdomen showed a slight abnormal texture of the liver and gallstones in motion, being suggestive of choledocholithiasis. After evaluation of causality and application of RUCAM, the reaction was classified as highly probable. Conclusions: The hepatic injury shown by the patient has a strong causal relationship with the use of ibuprofen. |
| first_indexed | 2024-12-23T14:13:39Z |
| format | Article |
| id | doaj.art-18388d77cabd4a9d84bd9ed9eb115284 |
| institution | Directory Open Access Journal |
| issn | 2179-5924 2316-7750 |
| language | English |
| last_indexed | 2024-12-23T14:13:39Z |
| publishDate | 2018-03-01 |
| publisher | Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| record_format | Article |
| series | Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| spelling | doaj.art-18388d77cabd4a9d84bd9ed9eb1152842022-12-21T17:43:59ZengSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdeRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde2179-59242316-77502018-03-019110.30968/rbfhss.2018.091.004248Induced by medication hepatotoxicity in an ambulatorial patient: case reportNÍLIA MARIA DE BRITO LIMA PRADOGLADISTONE CORREIA MESSIASGENARIO OLIVEIRA SANTOS JUNIORRAYMUNDO PARANÁBackground: Drug-induced hepatitis, also called toxic hepatitis or DILI (Drug Induced Liver Injury), accounts for about 2% of hospitalization cases of jaundice and liver damage is involved in 3-10% of all adverse drug reactions. Cases of hepatic injury associated with ibuprofen use are rare and the frequency of idiosyncratic hepatotoxicity is small. Objective: To report a case of hepatic injury induced by ibuprofen identified in a medium complexity outpatient clinic. Case report: A 48-year-old female patient was admitted to a Specialized Care Center in the southwestern state of Bahia for a consultation with an orthopedist complaining of low back pain, and ibuprofen and sodium dipyrone were prescribed to relieve symptoms. After 15 days of treatment, the patient returns to the service complaining of arthralgia in the upper limbs, right hand edema, jaundice, coluria, fecal suppura, asthenia and intense pruritus. From the investigation of the presented case, viral and autoimmune etiologies were ruled out. Ultrasonography of the total abdomen showed a slight abnormal texture of the liver and gallstones in motion, being suggestive of choledocholithiasis. After evaluation of causality and application of RUCAM, the reaction was classified as highly probable. Conclusions: The hepatic injury shown by the patient has a strong causal relationship with the use of ibuprofen.https://rbfhss.org.br/sbrafh/article/view/309 |
| spellingShingle | NÍLIA MARIA DE BRITO LIMA PRADO GLADISTONE CORREIA MESSIAS GENARIO OLIVEIRA SANTOS JUNIOR RAYMUNDO PARANÁ Induced by medication hepatotoxicity in an ambulatorial patient: case report Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| title | Induced by medication hepatotoxicity in an ambulatorial patient: case report |
| title_full | Induced by medication hepatotoxicity in an ambulatorial patient: case report |
| title_fullStr | Induced by medication hepatotoxicity in an ambulatorial patient: case report |
| title_full_unstemmed | Induced by medication hepatotoxicity in an ambulatorial patient: case report |
| title_short | Induced by medication hepatotoxicity in an ambulatorial patient: case report |
| title_sort | induced by medication hepatotoxicity in an ambulatorial patient case report |
| url | https://rbfhss.org.br/sbrafh/article/view/309 |
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