An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case report
A 58-year-old woman from Zimbabwe, with a history of untreated human immunodeficiency virus, presented with leonine facies and a diffuse rash. The rash occurred in the context of a 1-year history of constitutional symptoms and cognitive decline. Laboratory investigations confirmed that her human imm...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-02-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X19829616 |
| _version_ | 1818142185050079232 |
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| author | Connie Zhang Megan A Sander |
| author_facet | Connie Zhang Megan A Sander |
| author_sort | Connie Zhang |
| collection | DOAJ |
| description | A 58-year-old woman from Zimbabwe, with a history of untreated human immunodeficiency virus, presented with leonine facies and a diffuse rash. The rash occurred in the context of a 1-year history of constitutional symptoms and cognitive decline. Laboratory investigations confirmed that her human immunodeficiency virus had progressed to acquired immunodeficiency syndrome. Through imaging, tissue biopsies, and polymerase chain reaction, a diagnosis of disseminated histoplasmosis was made. Since there was no history of travel and histoplasmosis is not locally endemic, the patient likely contracted this fungal infection more than 7 years ago, while living in Africa. We speculate that the histoplasmosis remained latent until her immune system began to decline. The work-up and management of this rare cutaneous presentation of a systemic disease, which should be added to the list of “great mimickers” in dermatology, are discussed. |
| first_indexed | 2024-12-11T11:11:45Z |
| format | Article |
| id | doaj.art-1839b068f3d64e43a2b10b37a5d2e991 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-11T11:11:45Z |
| publishDate | 2019-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-1839b068f3d64e43a2b10b37a5d2e9912022-12-22T01:09:29ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2019-02-01710.1177/2050313X19829616An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case reportConnie ZhangMegan A SanderA 58-year-old woman from Zimbabwe, with a history of untreated human immunodeficiency virus, presented with leonine facies and a diffuse rash. The rash occurred in the context of a 1-year history of constitutional symptoms and cognitive decline. Laboratory investigations confirmed that her human immunodeficiency virus had progressed to acquired immunodeficiency syndrome. Through imaging, tissue biopsies, and polymerase chain reaction, a diagnosis of disseminated histoplasmosis was made. Since there was no history of travel and histoplasmosis is not locally endemic, the patient likely contracted this fungal infection more than 7 years ago, while living in Africa. We speculate that the histoplasmosis remained latent until her immune system began to decline. The work-up and management of this rare cutaneous presentation of a systemic disease, which should be added to the list of “great mimickers” in dermatology, are discussed.https://doi.org/10.1177/2050313X19829616 |
| spellingShingle | Connie Zhang Megan A Sander An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case report SAGE Open Medical Case Reports |
| title | An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case report |
| title_full | An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case report |
| title_fullStr | An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case report |
| title_full_unstemmed | An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case report |
| title_short | An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case report |
| title_sort | immigrant with acquired immunodeficiency syndrome presenting with a rash a case report |
| url | https://doi.org/10.1177/2050313X19829616 |
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