Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow
Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the underlying receptor–ligand bindings. While theoret...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-11-01
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| Series: | Theoretical and Applied Mechanics Letters |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095034915000847 |
| _version_ | 1811266204745072640 |
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| author | Yu Du Shuang Peng Yuhong Cui Shouqin Lü Yan Zhang Mian Long |
| author_facet | Yu Du Shuang Peng Yuhong Cui Shouqin Lü Yan Zhang Mian Long |
| author_sort | Yu Du |
| collection | DOAJ |
| description | Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the underlying receptor–ligand bindings. While theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately, how to couple these two processes remains unclear. Here we develop a combined model that couples cellular aggregation dynamics and adhesion kinetics under shear flow. The impacts of shear rate (or shear stress) and molecular binding affinity were elucidated. This study provides a unified model where the action of a fluid flow drives cell aggregation and adhesion under the modulations of the mechanical shear flow and receptor–ligand interaction kinetics. It offers an insight into understanding the relevant biological processes and functions. |
| first_indexed | 2024-04-12T20:39:02Z |
| format | Article |
| id | doaj.art-183d5d1c856e4e56a5630670c716533b |
| institution | Directory Open Access Journal |
| issn | 2095-0349 |
| language | English |
| last_indexed | 2024-04-12T20:39:02Z |
| publishDate | 2015-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Theoretical and Applied Mechanics Letters |
| spelling | doaj.art-183d5d1c856e4e56a5630670c716533b2022-12-22T03:17:29ZengElsevierTheoretical and Applied Mechanics Letters2095-03492015-11-015621622110.1016/j.taml.2015.09.004Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flowYu Du0Shuang Peng1Yuhong Cui2Shouqin Lü3Yan Zhang4Mian Long5Center of Biomechanics and Bioengineering, Institute of Mechanics, Beijing 100190, ChinaCenter of Biomechanics and Bioengineering, Institute of Mechanics, Beijing 100190, ChinaDepartment of Mechanics, Tianjin University, Tianjin 300072, ChinaCenter of Biomechanics and Bioengineering, Institute of Mechanics, Beijing 100190, ChinaCenter of Biomechanics and Bioengineering, Institute of Mechanics, Beijing 100190, ChinaCenter of Biomechanics and Bioengineering, Institute of Mechanics, Beijing 100190, ChinaBlood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the underlying receptor–ligand bindings. While theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately, how to couple these two processes remains unclear. Here we develop a combined model that couples cellular aggregation dynamics and adhesion kinetics under shear flow. The impacts of shear rate (or shear stress) and molecular binding affinity were elucidated. This study provides a unified model where the action of a fluid flow drives cell aggregation and adhesion under the modulations of the mechanical shear flow and receptor–ligand interaction kinetics. It offers an insight into understanding the relevant biological processes and functions.http://www.sciencedirect.com/science/article/pii/S2095034915000847Cell adhesionAggregationKineticsShear flow |
| spellingShingle | Yu Du Shuang Peng Yuhong Cui Shouqin Lü Yan Zhang Mian Long Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow Theoretical and Applied Mechanics Letters Cell adhesion Aggregation Kinetics Shear flow |
| title | Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow |
| title_full | Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow |
| title_fullStr | Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow |
| title_full_unstemmed | Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow |
| title_short | Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow |
| title_sort | combined modeling of cell aggregation and adhesion mediated by receptor ligand interactions under shear flow |
| topic | Cell adhesion Aggregation Kinetics Shear flow |
| url | http://www.sciencedirect.com/science/article/pii/S2095034915000847 |
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