Colistin Use in European Livestock: Veterinary Field Data on Trends and Perspectives for Further Reduction
Polymyxin E (colistin) is a medically important active substance both in human and veterinary medicine. Colistin has been used in veterinary medicine since the 1950s. Due to the discovery of the plasmid-borne <i>mcr</i> gene in 2015 and the simultaneously increased importance in human me...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-7381/9/11/650 |
| _version_ | 1797463801506824192 |
|---|---|
| author | Wiebke Jansen Jobke van Hout Jeanine Wiegel Despoina Iatridou Ilias Chantziaras Nancy De Briyne |
| author_facet | Wiebke Jansen Jobke van Hout Jeanine Wiegel Despoina Iatridou Ilias Chantziaras Nancy De Briyne |
| author_sort | Wiebke Jansen |
| collection | DOAJ |
| description | Polymyxin E (colistin) is a medically important active substance both in human and veterinary medicine. Colistin has been used in veterinary medicine since the 1950s. Due to the discovery of the plasmid-borne <i>mcr</i> gene in 2015 and the simultaneously increased importance in human medicine as a last-resort antibiotic, the use of colistin for animals was scrutinised. Though veterinary colistin sales dropped by 76.5% between 2011 to 2020, few studies evaluated real-world data on the use patterns of colistin in different European countries and sectors. A survey among veterinarians revealed that 51.9% did not use or ceased colistin, 33.4% decreased their use, 10.4% stabilised their use, and 2.7% increased use. The most important indications for colistin use were gastrointestinal diseases in pigs followed by septicaemia in poultry. A total of 106 (16.0%) responding veterinarians reported governmental/industry restrictions regarding colistin use, most commonly mentioning “use only after susceptibility testing” (57%). In brief, colistin was perceived as an essential last-resort antibiotic in veterinary medicine for <i>E. coli</i> infections in pigs and poultry, where there is no alternative legal, safe, and efficacious antimicrobial available. To further reduce the need for colistin, synergistic preventive measures, including improved biosecurity, husbandry, and vaccinations, must be employed. |
| first_indexed | 2024-03-09T17:55:53Z |
| format | Article |
| id | doaj.art-183dd28886ef40fea3813c57db2fd1b2 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T17:55:53Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-183dd28886ef40fea3813c57db2fd1b22023-11-24T10:18:01ZengMDPI AGVeterinary Sciences2306-73812022-11-0191165010.3390/vetsci9110650Colistin Use in European Livestock: Veterinary Field Data on Trends and Perspectives for Further ReductionWiebke Jansen0Jobke van Hout1Jeanine Wiegel2Despoina Iatridou3Ilias Chantziaras4Nancy De Briyne5Federation of Veterinarians of Europe (FVE), Rue Victor Oudart 7, 1030 Brussels, BelgiumRoyal GD, Arnsbergstraat 7, 7418 EZ Deventer, The NetherlandsRoyal GD, Arnsbergstraat 7, 7418 EZ Deventer, The NetherlandsFederation of Veterinarians of Europe (FVE), Rue Victor Oudart 7, 1030 Brussels, BelgiumVeterinary Epidemiology Unit, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, BelgiumFederation of Veterinarians of Europe (FVE), Rue Victor Oudart 7, 1030 Brussels, BelgiumPolymyxin E (colistin) is a medically important active substance both in human and veterinary medicine. Colistin has been used in veterinary medicine since the 1950s. Due to the discovery of the plasmid-borne <i>mcr</i> gene in 2015 and the simultaneously increased importance in human medicine as a last-resort antibiotic, the use of colistin for animals was scrutinised. Though veterinary colistin sales dropped by 76.5% between 2011 to 2020, few studies evaluated real-world data on the use patterns of colistin in different European countries and sectors. A survey among veterinarians revealed that 51.9% did not use or ceased colistin, 33.4% decreased their use, 10.4% stabilised their use, and 2.7% increased use. The most important indications for colistin use were gastrointestinal diseases in pigs followed by septicaemia in poultry. A total of 106 (16.0%) responding veterinarians reported governmental/industry restrictions regarding colistin use, most commonly mentioning “use only after susceptibility testing” (57%). In brief, colistin was perceived as an essential last-resort antibiotic in veterinary medicine for <i>E. coli</i> infections in pigs and poultry, where there is no alternative legal, safe, and efficacious antimicrobial available. To further reduce the need for colistin, synergistic preventive measures, including improved biosecurity, husbandry, and vaccinations, must be employed.https://www.mdpi.com/2306-7381/9/11/650colistinpolymyxinsantimicrobial resistanceAMRantimicrobial useAMU |
| spellingShingle | Wiebke Jansen Jobke van Hout Jeanine Wiegel Despoina Iatridou Ilias Chantziaras Nancy De Briyne Colistin Use in European Livestock: Veterinary Field Data on Trends and Perspectives for Further Reduction Veterinary Sciences colistin polymyxins antimicrobial resistance AMR antimicrobial use AMU |
| title | Colistin Use in European Livestock: Veterinary Field Data on Trends and Perspectives for Further Reduction |
| title_full | Colistin Use in European Livestock: Veterinary Field Data on Trends and Perspectives for Further Reduction |
| title_fullStr | Colistin Use in European Livestock: Veterinary Field Data on Trends and Perspectives for Further Reduction |
| title_full_unstemmed | Colistin Use in European Livestock: Veterinary Field Data on Trends and Perspectives for Further Reduction |
| title_short | Colistin Use in European Livestock: Veterinary Field Data on Trends and Perspectives for Further Reduction |
| title_sort | colistin use in european livestock veterinary field data on trends and perspectives for further reduction |
| topic | colistin polymyxins antimicrobial resistance AMR antimicrobial use AMU |
| url | https://www.mdpi.com/2306-7381/9/11/650 |
| work_keys_str_mv | AT wiebkejansen colistinuseineuropeanlivestockveterinaryfielddataontrendsandperspectivesforfurtherreduction AT jobkevanhout colistinuseineuropeanlivestockveterinaryfielddataontrendsandperspectivesforfurtherreduction AT jeaninewiegel colistinuseineuropeanlivestockveterinaryfielddataontrendsandperspectivesforfurtherreduction AT despoinaiatridou colistinuseineuropeanlivestockveterinaryfielddataontrendsandperspectivesforfurtherreduction AT iliaschantziaras colistinuseineuropeanlivestockveterinaryfielddataontrendsandperspectivesforfurtherreduction AT nancydebriyne colistinuseineuropeanlivestockveterinaryfielddataontrendsandperspectivesforfurtherreduction |