10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest
Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth. Methods: Cell growth was measured by...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2019-10-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-27761 |
| _version_ | 1818082562699952128 |
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| author | Andrea Rasmussen Kaylee Murphy David W. Hoskin |
| author_facet | Andrea Rasmussen Kaylee Murphy David W. Hoskin |
| author_sort | Andrea Rasmussen |
| collection | DOAJ |
| description | Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth. Methods: Cell growth was measured by MTT assays, flow cytometry was used to assess cell proliferation, cytotoxicity and cell cycle progression, and western blotting was used to measure cyclin protein expression. Results: Ovarian cancer cells that were treated with 10-gingerol experienced a time- and dose-dependent decrease in cell number, which was due to a reduction in cell proliferation rather than a cytotoxic effect. Reduced proliferation of 10-gingerol-treated ovarian cancer cells was associated with an increased percentage of cells in G2 phase of the cell cycle and a corresponding reduction in the percentage of cells in G1. Ovarian cancer cells also showed decreased cyclin A, B1, and D3 expression following exposure to 10-gingerol. Conclusion: These findings revealed that 10-gingerol caused a G2 arrest-associated suppression of ovarian cancer cell growth, which may be exploited in the management of ovarian cancer. <br /> |
| first_indexed | 2024-12-10T19:24:05Z |
| format | Article |
| id | doaj.art-183eed9cff084398941155f041cbe428 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-10T19:24:05Z |
| publishDate | 2019-10-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-183eed9cff084398941155f041cbe4282022-12-22T01:36:25ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082019-10-019468568910.15171/apb.2019.080apb-2776110-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 ArrestAndrea Rasmussen0Kaylee Murphy1David W. Hoskin2Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth. Methods: Cell growth was measured by MTT assays, flow cytometry was used to assess cell proliferation, cytotoxicity and cell cycle progression, and western blotting was used to measure cyclin protein expression. Results: Ovarian cancer cells that were treated with 10-gingerol experienced a time- and dose-dependent decrease in cell number, which was due to a reduction in cell proliferation rather than a cytotoxic effect. Reduced proliferation of 10-gingerol-treated ovarian cancer cells was associated with an increased percentage of cells in G2 phase of the cell cycle and a corresponding reduction in the percentage of cells in G1. Ovarian cancer cells also showed decreased cyclin A, B1, and D3 expression following exposure to 10-gingerol. Conclusion: These findings revealed that 10-gingerol caused a G2 arrest-associated suppression of ovarian cancer cell growth, which may be exploited in the management of ovarian cancer. <br />https://apb.tbzmed.ac.ir/PDF/apb-27761cell cycleproliferationginger10-gingerolovarian cancer |
| spellingShingle | Andrea Rasmussen Kaylee Murphy David W. Hoskin 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest Advanced Pharmaceutical Bulletin cell cycle proliferation ginger 10-gingerol ovarian cancer |
| title | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
| title_full | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
| title_fullStr | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
| title_full_unstemmed | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
| title_short | 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest |
| title_sort | 10 gingerol inhibits ovarian cancer cell growth by inducing g2 arrest |
| topic | cell cycle proliferation ginger 10-gingerol ovarian cancer |
| url | https://apb.tbzmed.ac.ir/PDF/apb-27761 |
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