Cohort profile: a prospective Australian cohort study of women’s reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM)
Purpose Previous studies have identified associations between individual reproductive factors and chronic disease risk among postmenopausal women. However, few have investigated the association of different markers of reproductive function, their interactions and risk factors of chronic disease amon...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/10/e064333.full |
| _version_ | 1811335105341292544 |
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| author | Mark Hamer Emmanuel Stamatakis Deborah Loxton Jenny Doust Shyamali Dharmage Gita D Mishra Rachel R Huxley Grant Montgomery Bu Beng Yeap Jenny A Visser Annette Dobson Jason Abbott Gregore Iven Mielke Hsin-Fang Chung Hsiu-Wen Chan Harold McIntyre |
| author_facet | Mark Hamer Emmanuel Stamatakis Deborah Loxton Jenny Doust Shyamali Dharmage Gita D Mishra Rachel R Huxley Grant Montgomery Bu Beng Yeap Jenny A Visser Annette Dobson Jason Abbott Gregore Iven Mielke Hsin-Fang Chung Hsiu-Wen Chan Harold McIntyre |
| author_sort | Mark Hamer |
| collection | DOAJ |
| description | Purpose Previous studies have identified associations between individual reproductive factors and chronic disease risk among postmenopausal women. However, few have investigated the association of different markers of reproductive function, their interactions and risk factors of chronic disease among women approaching menopause. The Menarche-to-PreMenopause (M-PreM) Study aims to examine the relationship between reproductive factors across the reproductive lifespan and risk indicators for chronic disease among women in their early-to-mid-40s. The purpose of this cohort profile paper is to describe the rationale, study design and participant characteristics of the M-PreM Study.Participants Women born in 1973–1978 who participated in the Australian Longitudinal Study on Women’s Health (ALSWH) were invited to undertake a clinical or self-administered assessment. A total of 1278 women were recruited from June 2019 to June 2021.Findings to date The study measures included functional, cognitive and cardiometabolic tests, anthropometry, spirometry, respiratory health questionnaires, physical activity, sleep patterns, sex hormones, and cardiovascular and metabolic markers; whereas blood and saliva samples were used for the analysis of genetic variants of genes associated with reproductive characteristics and chronic disease. The mean age of the clinic and self-assessed participants was 44.6 and 45.3 years, respectively. The menopausal status of participants was similar between the two arms of the study: 38%–41% premenopausal, 20% perimenopausal, and 36% took oral contraception or hormone replacement therapy. Approximately 80% of women had at least one child and participants reported experiencing pregnancy complications: preterm birth (8%–13% of pregnancies), gestational diabetes (10%) and gestational hypertension (10%–15%).Future plans The biomedical data collected in the M-PreM Study will be linked to existing ALSWH survey data on sociodemographic factors, health behaviour, reproductive function, and early life factors collected over the past 20 years and health administrative data. The association between reproductive factors and risk indicators of chronic disease will be analysed. |
| first_indexed | 2024-04-13T17:19:08Z |
| format | Article |
| id | doaj.art-183f7edf801d44509f4c66a457699d6d |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-13T17:19:08Z |
| publishDate | 2022-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-183f7edf801d44509f4c66a457699d6d2022-12-22T02:38:02ZengBMJ Publishing GroupBMJ Open2044-60552022-10-01121010.1136/bmjopen-2022-064333Cohort profile: a prospective Australian cohort study of women’s reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM)Mark Hamer0Emmanuel Stamatakis1Deborah Loxton2Jenny Doust3Shyamali Dharmage4Gita D Mishra5Rachel R Huxley6Grant Montgomery7Bu Beng Yeap8Jenny A Visser9Annette Dobson10Jason Abbott11Gregore Iven Mielke12Hsin-Fang Chung13Hsiu-Wen Chan14Harold McIntyre15Division of Surgery and Interventional Sciences, Faculty of Medical Sciences, University College London, London, UKCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, AustraliaCentre for Women`s Health Research, The University of Newcastle, Newcastle, New South Wales, AustraliaSchool of Public Health, The University of Queensland, Brisbane, Queensland, AustraliaAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Carlton, Victoria, AustraliaSchool of Public Health, The University of Queensland, Brisbane, Queensland, AustraliaFaculty of Health, Deakin University, Burwood, Victoria, AustraliaInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, AustraliaMedical School, The University of Western Australia, Perth, Western Australia, AustraliaDepartment of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The NetherlandsSchool of Public Health, The University of Queensland, Brisbane, Queensland, AustraliaSchool of Women`s and Children`s Health, University of New South Wales, Sydney, New South Wales, AustraliaSchool of Public Health, The University of Queensland, Brisbane, Queensland, AustraliaSchool of Public Health, The University of Queensland, Brisbane, Queensland, AustraliaSchool of Public Health, The University of Queensland, Brisbane, Queensland, AustraliaSchool of Medicine, The University of Queensland, Brisbane, Queensland, AustraliaPurpose Previous studies have identified associations between individual reproductive factors and chronic disease risk among postmenopausal women. However, few have investigated the association of different markers of reproductive function, their interactions and risk factors of chronic disease among women approaching menopause. The Menarche-to-PreMenopause (M-PreM) Study aims to examine the relationship between reproductive factors across the reproductive lifespan and risk indicators for chronic disease among women in their early-to-mid-40s. The purpose of this cohort profile paper is to describe the rationale, study design and participant characteristics of the M-PreM Study.Participants Women born in 1973–1978 who participated in the Australian Longitudinal Study on Women’s Health (ALSWH) were invited to undertake a clinical or self-administered assessment. A total of 1278 women were recruited from June 2019 to June 2021.Findings to date The study measures included functional, cognitive and cardiometabolic tests, anthropometry, spirometry, respiratory health questionnaires, physical activity, sleep patterns, sex hormones, and cardiovascular and metabolic markers; whereas blood and saliva samples were used for the analysis of genetic variants of genes associated with reproductive characteristics and chronic disease. The mean age of the clinic and self-assessed participants was 44.6 and 45.3 years, respectively. The menopausal status of participants was similar between the two arms of the study: 38%–41% premenopausal, 20% perimenopausal, and 36% took oral contraception or hormone replacement therapy. Approximately 80% of women had at least one child and participants reported experiencing pregnancy complications: preterm birth (8%–13% of pregnancies), gestational diabetes (10%) and gestational hypertension (10%–15%).Future plans The biomedical data collected in the M-PreM Study will be linked to existing ALSWH survey data on sociodemographic factors, health behaviour, reproductive function, and early life factors collected over the past 20 years and health administrative data. The association between reproductive factors and risk indicators of chronic disease will be analysed.https://bmjopen.bmj.com/content/12/10/e064333.full |
| spellingShingle | Mark Hamer Emmanuel Stamatakis Deborah Loxton Jenny Doust Shyamali Dharmage Gita D Mishra Rachel R Huxley Grant Montgomery Bu Beng Yeap Jenny A Visser Annette Dobson Jason Abbott Gregore Iven Mielke Hsin-Fang Chung Hsiu-Wen Chan Harold McIntyre Cohort profile: a prospective Australian cohort study of women’s reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM) BMJ Open |
| title | Cohort profile: a prospective Australian cohort study of women’s reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM) |
| title_full | Cohort profile: a prospective Australian cohort study of women’s reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM) |
| title_fullStr | Cohort profile: a prospective Australian cohort study of women’s reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM) |
| title_full_unstemmed | Cohort profile: a prospective Australian cohort study of women’s reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM) |
| title_short | Cohort profile: a prospective Australian cohort study of women’s reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM) |
| title_sort | cohort profile a prospective australian cohort study of women s reproductive characteristics and risk of chronic disease from menarche to premenopause m prem |
| url | https://bmjopen.bmj.com/content/12/10/e064333.full |
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